Zobrazeno 1 - 10
of 1 812
pro vyhledávání: '"galnac"'
Publikováno v:
BMC Microbiology, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background The metabolism of gut microbiota produces bioactive metabolites that modulate host physiology and promote self-growth. Erysipelotrichaceae is one of the most common anaerobic microorganism families in the gut, which has been disco
Externí odkaz:
https://doaj.org/article/6b4d707660cc4ece938cccb7d2439c89
Autor:
I. P. Shilovskiy, G. B. Pasikhov, V. V. Smirnov, I. A. Kofiadi, M. V. Popova, P. A. Strueva, M. R. Khaitov
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 24, Iss 2, Pp 157-171 (2024)
INTRODUCTION. Small interfering RNAs (siRNAs) are among the most promising types of therapeutic nucleic acids aiming at the inhibition of pathogenetically relevant gene expression through the RNA interference mechanism. However, the limited bioavaila
Externí odkaz:
https://doaj.org/article/eb2d2fbfb84c4e88a2f8d5a7cea9133d
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 10, Pp 100635- (2024)
Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide. If left untreated, MASLD can progress from simple hepatic steatosis to metabolic dysfunction–associated steatohepatitis, which
Externí odkaz:
https://doaj.org/article/174cbfc5e92347ebb4f4619fa04bfafb
Publikováno v:
mLife, Vol 3, Iss 1, Pp 57-73 (2024)
Abstract O‐glycosylation is an ancient yet underappreciated protein posttranslational modification, on which many bacteria and viruses heavily rely to perform critical biological functions involved in numerous infectious diseases or even cancer. Bu
Externí odkaz:
https://doaj.org/article/a3a9b5976da141c7a4c74d36859a49ae
Autor:
Sophie Schöllkopf, Stefan Rathjen, Micaela Graglia, Nina Was, Eliot Morrison, Adrien Weingärtner, Lucas Bethge, Judith Hauptmann, Marie Wikström Lindholm
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102336- (2024)
Phosphorothioates (PSs) can be essential in stabilizing therapeutic oligonucleotides against enzymatic degradation. However, unless synthesis is performed with stereodefined amidites, each PS introduces a chemically undefined stereocenter, resulting
Externí odkaz:
https://doaj.org/article/34571e61594a4e63803a264e06e093a5
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The protozoan parasite Entamoeba histolytica is the causative agent of amebiasis, with clinical outcomes ranging from asymptomatic infections to severe invasive diseases. The innate immune system, particularly macrophages, is of paramount importance
Externí odkaz:
https://doaj.org/article/ae5388d24a1349b8a84b3d1132d158ca
Autor:
Qian Li, Taohua Geng, Haiyan Li, Shuquan Zheng, Sara Svedlund, Liming Gan, Ann-Charlotte Egnell, Shan Gao, Rui Chen, Pei Hu
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e31924- (2024)
Small interference RNA (siRNA) is a class of short double-stranded RNA molecules that cause mRNA degradation through an RNA interference mechanism and is a promising therapeutic modality. RBD1016 is a siRNA drug in clinical development for the treatm
Externí odkaz:
https://doaj.org/article/6797ab69ec9547f5891b25d823ad80a4
Publikováno v:
Food Materials Research, Vol 4, Iss 1, Pp 1-6 (2024)
Edible bird's nest (EBN) is considered a delicacy in Chinese cuisine. The nests are produced by male swiftlets (Aerodramus sp.). Due to their high price, the nutritional benefit from EBN can currently only be afforded by affluent consumers. Therefore
Externí odkaz:
https://doaj.org/article/31b28ea3eaf84ee1bedb0c65c3766d57
Autor:
Joselin Díaz-Valdez, Rosario Javier-Reyna, Sarita Montaño, Daniel Talamás-Lara, Esther Orozco
Publikováno v:
Frontiers in Parasitology, Vol 3 (2024)
The retromer is a highly conserved eukaryotic complex formed by the cargo selective complex (CSC) and the sorting nexin (SNX) dimer subcomplexes. Its function is protein recycling and recovery from the endosomes to conduct the target molecules to the
Externí odkaz:
https://doaj.org/article/1abccf0bd9e946078fce3d7fca1ef0d6
Autor:
Huiyan Sun, Xinxia Wang, Yongqiang Li, Yingzhi Shen, Lin Zhang, Yingjie Xu, Junling Liu, Xuemei Fan
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 938 (2024)
Hyperuricemia, i.e., increased plasma uric acid concentration, is a common problem in clinical practice, leading to gout or nephrolithiasis, and is associated with other disorders, such as metabolic syndrome, cardiovascular disease, and chronic renal
Externí odkaz:
https://doaj.org/article/371899d7624f4dee9428f2e6bc2e5aca