HIV-1 N-myristoylation-dependent hijacking of late endosomes/lysosomes to drive Gag assembly in macrophages.

Autor: Guajardo-Contreras GI; Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada.; Lady Davis Institute at the Jewish General Hospital, Montreal, QC H3T 1E2, Canada., Abdalla AL; Lady Davis Institute at the Jewish General Hospital, Montreal, QC H3T 1E2, Canada.; Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada., Chen A; The Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Niu M; Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada., Beauchamp E; Pacylex Pharmaceuticals Inc., Edmonton, AB T5J 4P6, Canada., Berthiaume LG; Pacylex Pharmaceuticals Inc., Edmonton, AB T5J 4P6, Canada.; Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada., Cochrane AW; The Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Mouland AJ; Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada.; Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada.

Publikováno v: Journal of cell science [J Cell Sci] 2024 Nov 15; Vol. 137 (22). Date of Electronic Publication: 2024 Nov 21.

Putting a Kink in HIV-1 Particle Infectivity: Rocaglamide Inhibits HIV-1 Replication by Altering Gag-Genomic RNA Interaction.

Autor: Rosenfeld P; Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada., Singh G; Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, MN 55108, USA., Paz Herrera A; Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA., Ji J; Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA., Seufzer B; Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, MN 55108, USA., Heng X; Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA., Boris-Lawrie K; Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, MN 55108, USA., Cochrane A; Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.

Publikováno v: Viruses [Viruses] 2024 Sep 23; Vol. 16 (9). Date of Electronic Publication: 2024 Sep 23.

Identification of a Clade-Specific HLA-C*03:02 CTL Epitope GY9 Derived from the HIV-1 p17 Matrix Protein.

Autor: Kyobe S; Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda., Mwesigwa S; Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda.; Department of Immunology and Molecular Biology, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda., Nkurunungi G; The Medical Research Council/Uganda Virus Research Institute & London School Hygine Tropical Medicine Uganda Research Unit, Entebbe P.O. Box 49, Uganda.; Department of Infection Biology, London School of Hygiene & Tropical Medicine, Keppel Street London, London WC1E 7HT, UK., Retshabile G; Department of Biological Sciences, University of Botswana, Gaborone Private Bag UB 0022, Botswana., Egesa M; The Medical Research Council/Uganda Virus Research Institute & London School Hygine Tropical Medicine Uganda Research Unit, Entebbe P.O. Box 49, Uganda.; Department of Infection Biology, London School of Hygiene & Tropical Medicine, Keppel Street London, London WC1E 7HT, UK., Katagirya E; Department of Immunology and Molecular Biology, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda., Amujal M; Department of Immunology and Molecular Biology, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda., Mlotshwa BC; Department of Biological Sciences, University of Botswana, Gaborone Private Bag UB 0022, Botswana., Williams L; Department of Biological Sciences, University of Botswana, Gaborone Private Bag UB 0022, Botswana., Sendagire H; Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda., On Behalf Of The CAfGEN Consortium, Kiragga D; Baylor College of Medicine Children's Foundation, Kampala P.O. Box 72052, Uganda., Mardon G; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA., Matshaba M; Pediatric Retrovirology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.; Botswana-Baylor Children's Clinical Centre of Excellence, Gaborone Private Bag BR 129, Botswana., Hanchard NA; National Human Genome Research Institute, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA., Kyosiimire-Lugemwa J; The Medical Research Council/Uganda Virus Research Institute & London School Hygine Tropical Medicine Uganda Research Unit, Entebbe P.O. Box 49, Uganda., Robinson D; Department of Chemistry and Forensics, School of Science and Technology, Nottingham Trent University Clifton Lane, Nottingham NG11 8NS, UK.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Sep 06; Vol. 25 (17). Date of Electronic Publication: 2024 Sep 06.

Prediction of differential Gag versus Env responses to a mosaic HIV-1 vaccine regimen by HLA class I alleles.

Autor: Nelson GW; Basic Science Program Frederick National Laboratory for Cancer Research, National Cancer Institute and Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA., van Duijn J; Janssen Vaccines & Prevention, Leiden, the Netherlands., Yuki Y; Basic Science Program Frederick National Laboratory for Cancer Research, National Cancer Institute and Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA., Pau MG; Janssen Vaccines & Prevention, Leiden, the Netherlands., Tomaka F; Janssen Research and Development, Titusville, New Jersey, USA., Lavreys L; Janssen Infectious Diseases BV, Beerse, Belgium., DeRosa SC; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.; Division of Vaccine and Infectious Disease, Fred Hutchinson Cancer Center, Seattle, Washington, USA., McElrath MJ; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.; Division of Vaccine and Infectious Disease, Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA., Kirk GD; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Michael NL; US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Haas DW; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Deeks SG; Department of Medicine, University of California, San Francisco, California, USA., Wolinsky S; Division of Infectious Diseases, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Walker B; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA., Barouch DH; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Stieh D; Janssen Vaccines & Prevention, Leiden, the Netherlands., Carrington M; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.

Publikováno v: Journal of virology [J Virol] 2024 Aug 20; Vol. 98 (8), pp. e0028124. Date of Electronic Publication: 2024 Jul 24.

Human Immunodeficiency Virus Type 1 Gag Polyprotein Modulates Membrane Physical Properties like a Surfactant: Potential Implications for Virus Assembly.

Autor: Denieva ZG; A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, RAS, Leninsky pr., 31, bld. 4, 119071 Moscow, Russia., Kuzmin PI; A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, RAS, Leninsky pr., 31, bld. 4, 119071 Moscow, Russia., Galimzyanov TR; A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, RAS, Leninsky pr., 31, bld. 4, 119071 Moscow, Russia., Datta SAK; Retroviral Assembly Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702-1201, United States., Rein A; Retroviral Assembly Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702-1201, United States., Batishchev OV; A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, RAS, Leninsky pr., 31, bld. 4, 119071 Moscow, Russia.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2024 Aug 09; Vol. 10 (8), pp. 2870-2885. Date of Electronic Publication: 2024 Jun 25.