Zobrazeno 1 - 10
of 1 209
pro vyhledávání: '"gad65"'
Autor:
Aakash Mahesan, Aradhana Rohil, Prashant Jauhari, Madhavi Tripathi, Biswaroop Chakrabarty, Atin Kumar, Sheffali Gulati
Publikováno v:
Annals of Indian Academy of Neurology, Vol 27, Iss 5, Pp 576-579 (2024)
Immune-mediated epilepsy (IME) constitutes a substantial proportion of drug-refractory epilepsies. Rapid diagnosis and prompt immunosuppression are required along with antiseizure medications (ASMs). Here we report three unrelated children who presen
Externí odkaz:
https://doaj.org/article/2c1092689ea141dd9d261d5c8c641c07
Akademický článek
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Autor:
Alexander Lind, Eva Freyhult, Felipe de Jesus Cortez, Anita Ramelius, Rasmus Bennet, Peter V. Robinson, David Seftel, David Gebhart, Devangkumar Tandel, Marlena Maziarz, Helena Elding Larsson, Markus Lundgren, Annelie Carlsson, Anna-Lena Nilsson, Malin Fex, Carina Törn, Daniel Agardh, Cheng-ting Tsai, Åke Lernmark, Martina Persson, Gun Forsander, Johnny Ludvigsson, Ulf Samuelsson, Claude Marcus
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105144- (2024)
Summary: Background: Two or more autoantibodies against either insulin (IAA), glutamic acid decarboxylase (GADA), islet antigen-2 (IA-2A) or zinc transporter 8 (ZnT8A) denote stage 1 (normoglycemia) or stage 2 (dysglycemia) type 1 diabetes prior to s
Externí odkaz:
https://doaj.org/article/a4975652334e42b38b70cf638422fb61
Autor:
Xinyi Wang, Mengxin Xie, Tengjiao Li, Jiandong Shi, Meini Wu, Shihan Zhang, Jing Sun, Yunzhang Hu
Publikováno v:
Vaccines, Vol 12, Iss 10, p 1117 (2024)
Background: Type 1 diabetes (T1D) is an autoimmune disorder characterised by the destruction of insulin-producing beta cells in the pancreatic islets, resulting from a breakdown in immunological tolerance. Currently, T1D treatment primarily relies on
Externí odkaz:
https://doaj.org/article/9fb155ee01e5434da66b1ad8772fe886
Autor:
Neihenuo Chuzho, Neetu Mishra, Nikhil Tandon, Uma Kanga, Gunja Mishra, Akanksha Sharma, Narinder K. Mehra, Neeraj Kumar
Publikováno v:
Journal of Diabetes, Vol 15, Iss 7, Pp 607-621 (2023)
Abstract Aim We planned this study to identify diabetogenic glutamic acid decarboxylase (GAD65) peptides possibly responsible for human leucocyte antigen (HLA)‐DR3/DQ2‐mediated activation of GAD65‐specific CD4 T cells in type 1 diabetes (T1D).
Externí odkaz:
https://doaj.org/article/29ef37f916e442c4abfe137d2e417e0c
Akademický článek
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Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
ObjectiveTo explore the clinical manifestations of glutamic acid decarboxylase 65 (GAD65) antibody-positive patients with extraocular symptoms and the possible mechanism.MethodAssays for the presence of GAD65 antibodies were performed on patients’
Externí odkaz:
https://doaj.org/article/9be3a00a17f34645818372090c3cafc9
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundGlutamic acid decarboxylase (GAD) is the rate-limiting enzyme for the synthesis of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. Antibodies against glutamic acid decarboxylase (GAD) are
Externí odkaz:
https://doaj.org/article/8f3a567a83be41edbff1865ad8035bd0
Autor:
Joana R. N. Lemos, Raffaella Poggioli, Jonathan Ambut, Nujen C. Bozkurt, Ana M. Alvarez, Nathalia Padilla, Francesco Vendrame, Camillo Ricordi, David A. Baidal, Rodolfo Alejandro
Publikováno v:
Frontiers in Clinical Diabetes and Healthcare, Vol 4 (2023)
IntroductionIslet transplantation (ITx) shows promise in treating T1D, but the role of islet autoantibodies on graft survival has not been clearly elucidated. We aimed to analyze the effect of GAD65 and IA2 autoantibody status on graft survival and a
Externí odkaz:
https://doaj.org/article/f9eff760b541458ab4d48f7391736d28
Publikováno v:
JCRPE, Vol 15, Iss 1, Pp 35-41 (2023)
INTRODUCTION: Type 1 diabetes autoantibodies are directed against multiple antigens including: glutamic acid decarboxylase, protein tyrosine phosphatase-like islet antigen 2 (IA2), insulin (IAA), and Zinc transporter 8 protein (ZnT8). The aim of our
Externí odkaz:
https://doaj.org/article/91643e59084445ad8eedc99cef63ba2b