Zobrazeno 1 - 10
of 25
pro vyhledávání: '"gRNA, guide RNA"'
Autor:
Sara M. Dann, Zheng Zhou, Suxia Yao, Wenjing Yang, Anthony J. Bilotta, Yu Yu, Xiaojing Zhao, Chunyan Ma, Yingzi Cong, Yanbo Yu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1023-1044 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background and Aims Gut bacteria-derived short-chain fatty acids (SCFAs) play crucial roles in the maintenance of intestinal homeostasis. However, how SCFAs regulate epithelial turnover and tissue repair remain incompletely understood. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d4114ca3e9339e1b8954fbfbdd4b9d
http://www.sciencedirect.com/science/article/pii/S2352345X20301909
http://www.sciencedirect.com/science/article/pii/S2352345X20301909
Autor:
A. Cota-Coronado, O.R. Hernández-Pérez, Néstor F. Díaz, Pavel H. Lugo-Fabres, N. Emmanuel Díaz-Martínez, Valeria Valadez-Barba, Eduardo Padilla-Camberos
Publikováno v:
Regenerative Therapy, Vol 15, Iss, Pp 332-339 (2020)
Regenerative Therapy
Regenerative Therapy
Neurodegenerative disorders such as Parkinson's and Alzheimer's disease, are fundamental health concerns all around the world. The development of novel treatments and new techniques to address these disorders, are being actively studied by researcher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5533df458e5d5b5603371b246a30631c
http://www.sciencedirect.com/science/article/pii/S2352320420300894
http://www.sciencedirect.com/science/article/pii/S2352320420300894
Autor:
Ping Zhang, Dingyuan Ma, Li-Ying Peng, Ning-Yuan Sun, Jun Chen, Xiao-Wei Zhang, Weiwei Tang, Lin An
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1397-1413 (2020)
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1397-1413 (2020)
Pyroptosis is a form of programmed cell death, and recently described as a new molecular mechanism of chemotherapy drugs in the treatment of tumors. Miltirone, a derivative of phenanthrene-quinone isolated from the root of Salvia miltiorrhiza Bunge,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750fb5bad337ad6389f2c3000e4927a2
http://europepmc.org/articles/PMC7488361
http://europepmc.org/articles/PMC7488361
Autor:
Sun, Lingbo, Konstantinidi, Andriana, Ye, Zilu, Nason, Rebecca, Zhang, Yuecheng, Büll, Christian, Kahl-Knutson, Barbro, Hansen, Lars, Leffler, Hakon, Vakhrushev, Sergey Y., Yang, Zhang, Clausen, Henrik, Narimatsu, Yoshiki
Publikováno v:
Journal of Biological Chemistry
Sun, L, Konstantinidi, A, Ye, Z, Nason, R, Zhang, Y, Büll, C, Kahl-Knutson, B, Hansen, L, Leffler, H, Vakhrushev, S Y, Yang, Z, Clausen, H & Narimatsu, Y 2022, ' Installation of O-glycan sulfation capacities in human HEK293 cells for display of sulfated mucins ', Journal of Biological Chemistry, vol. 298, no. 2, 101382 . https://doi.org/10.1016/j.jbc.2021.101382
The Journal of Biological Chemistry
Sun, L, Konstantinidi, A, Ye, Z, Nason, R, Zhang, Y, Büll, C, Kahl-Knutson, B, Hansen, L, Leffler, H, Vakhrushev, S Y, Yang, Z, Clausen, H & Narimatsu, Y 2022, ' Installation of O-glycan sulfation capacities in human HEK293 cells for display of sulfated mucins ', Journal of Biological Chemistry, vol. 298, no. 2, 101382 . https://doi.org/10.1016/j.jbc.2021.101382
The Journal of Biological Chemistry
The human genome contains at least 35 genes that encode Golgi sulfotransferases that function in the secretory pathway, where they are involved in decorating glycosaminoglycans, glycolipids, and glycoproteins with sulfate groups. Although a number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad4f22b0bf4557ecd2722715b307d60
Autor:
Chung-Sik Choi, Meredith Gwin, Sarah Voth, Claire Kolb, Chun Zhou, Amy R. Nelson, Althea deWeever, Anna Koloteva, Naga S. Annamdevula, James M. Murphy, Brant M. Wagener, Jean-Francois Pittet, Ssang-Taek S. Lim, Ron Balczon, Troy Stevens, Mike T. Lin
Publikováno v:
The Journal of Biological Chemistry
Patients who recover from nosocomial pneumonia oftentimes exhibit long-lasting cognitive impairment comparable with what is observed in Alzheimer’s disease patients. We previously hypothesized that the lung endothelium contributes to infection-rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6871903b884d5aad142c120684cb3b12
https://pubmed.ncbi.nlm.nih.gov/34896150
https://pubmed.ncbi.nlm.nih.gov/34896150
Autor:
Jianglei Chen, Yanhong Du, Wenjing Wu, Siribhinya Benyajati, Dibyendu Chakraborty, Yusuke Takahashi, Xiang Ma, Yangxiong Li, Wentao Liang, Jian Xing Ma
Publikováno v:
The Journal of Biological Chemistry
Very low-density lipoprotein receptor (VLDLR) is a multifunctional transmembrane protein. Beyond the function of the full-length VLDLR in lipid transport, the soluble ectodomain of VLDLR (sVLDLR) confers anti-inflammatory and antiangiogenic roles in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5974b7bf59a8584fad41d82734272403
https://pubmed.ncbi.nlm.nih.gov/34509473
https://pubmed.ncbi.nlm.nih.gov/34509473
Autor:
Christopher Green, Deanna L. Davis, Sarah Spiegel, Michael Maceyka, Usha Mahawar, Clement Oyeniran, Binks W. Wattenberg, Cynthia Weigel, Jason Newton, Briana N. James
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100082-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100082-(2021)
The serine palmitoyltransferase (SPT) complex catalyzes the rate-limiting step in the de novo biosynthesis of ceramides, the precursors of sphingolipids. The mammalian ORMDL isoforms (ORMDL1-3) are negative regulators of SPT. However, the roles of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db4a783bcfe3cd38f08db6299eb2fbf
http://europepmc.org/articles/PMC8167824
http://europepmc.org/articles/PMC8167824
Autor:
Gerald Klanert, Neža Novak, Heena Dhiman, Evgenija Serafimova, Valerie Schmieder, Helene Faustrup Kildegaard, Ly Ngoc Nguyen, Martina Baumann, Nicole Borth
Publikováno v:
Schmieder, V, Novak, N, Dhiman, H, Nguyen, L N, Serafimova, E, Klanert, G, Baumann, M, Kildegaard, H F & Borth, N 2021, ' A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells ', Biotechnology Reports, vol. 31, e00649 . https://doi.org/10.1016/j.btre.2021.e00649
Biotechnology Reports, Vol 31, Iss, Pp e00649-(2021)
Biotechnology Reports
Biotechnology Reports, Vol 31, Iss, Pp e00649-(2021)
Biotechnology Reports
Highlights • Development of a small-scale CRISPR/AsCpf1 screen in CHO. • Usage of paired gRNAs enables full deletion of coding or noncoding genomic regions. • Growth perturbing paired gRNAs identified. • Key points for considerations in futur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31d246764716135df37256ce4e0360d
https://orbit.dtu.dk/en/publications/2952ac8e-767c-4605-811b-710e6cd4ba19
https://orbit.dtu.dk/en/publications/2952ac8e-767c-4605-811b-710e6cd4ba19
Autor:
Darren R. Heintzman, Jonathan P. Schlebach, Madison T. Wright, Katherine R. Clowes, Justin T. Marinko, Lars Plate, Charles R. Sanders
Publikováno v:
The Journal of Biological Chemistry
Peripheral myelin protein 22 (PMP22) folds and trafficks inefficiently, with only 20% of newly expressed protein trafficking to the cell surface. This behavior is exacerbated in many of the mutants associated with Charcot–Marie–Tooth disease, mot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f7aa822492ff0debb73ba9d1a8ad87
https://pubmed.ncbi.nlm.nih.gov/33933451
https://pubmed.ncbi.nlm.nih.gov/33933451
Publikováno v:
Gene
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated Cas protein (CRISPR-Cas) has turned out to be a very important tool for the rapid detection of viruses. This can be used for the identification of the target site in a viru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051ae802461956473728f5cf10b066fe
https://doi.org/10.1016/j.gene.2021.146136
https://doi.org/10.1016/j.gene.2021.146136