Zobrazeno 1 - 10
of 87
pro vyhledávání: '"fully human antibody"'
Fully human monoclonal antibodies against Ebola virus possess complete protection in a hamster model
Autor:
Wujian Li, Wanying Yang, Xueqin Liu, Wujie Zhou, Shen Wang, Zhenshan Wang, Yongkun Zhao, Na Feng, Tiecheng Wang, Meng Wu, Liangpeng Ge, Xianzhu Xia, Feihu Yan
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
Ebola disease is a lethal viral hemorrhagic fever caused by ebolaviruses within the Filoviridae family with mortality rates of up to 90%. Monoclonal antibody (mAb) based therapies have shown great potential for the treatment of EVD. However, the pote
Externí odkaz:
https://doaj.org/article/8eda2434f93341e8b1ad66aa4b641510
Autor:
Xiaojie Chu, Seungmin Shin, Du-San Baek, Liyong Zhang, Alex Conard, Megan Shi, Ye-Jin Kim, Cynthia Adams, Maggie Hines, Xianglei Liu, Chuan Chen, Zehua Sun, Dontcho V. Jelev, John W. Mellors, Dimiter S. Dimitrov, Wei Li
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Prostate stem cell antigen (PSCA) is expressed in all stages of prostate cancer, including in advanced androgen-independent tumors and bone metastasis. PSCA may associate with prostate carcinogenesis and lineage plasticity in prostate cancer. PSCA is
Externí odkaz:
https://doaj.org/article/1f085d6811ce4dcda8bde14f50a5302f
Akademický článek
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Publikováno v:
FEBS Open Bio, Vol 12, Iss 8, Pp 1542-1557 (2022)
Glucocorticoid‐induced TNF receptor‐related (GITR) can act as a co‐stimulatory receptor, representing a potential target for safely enhancing immunotherapy efficacy. GITR is triggered by a GITR ligand or an agonist antibody and activates CD8+ a
Externí odkaz:
https://doaj.org/article/18c31dff14264b6bb4e923947ba750a3
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Xi Yang, Hang Chi, Meng Wu, Zhenshan Wang, Qiaoli Lang, Qiuxue Han, Xinyue Wang, Xueqin Liu, Yuanguo Li, Xiwen Wang, Nan Huang, Jinhao Bi, Hao Liang, Yuwei Gao, Yongkun Zhao, Na Feng, Songtao Yang, Tiecheng Wang, Xianzhu Xia, Liangpeng Ge
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The coronavirus disease 2019 pandemic has caused more than 532 million infections and 6.3 million deaths to date. The reactive and neutralizing fully human antibodies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are effective detec
Externí odkaz:
https://doaj.org/article/84a77eb83db04e2f92ca08917dd13038
Autor:
Yea Bin Cho, Ji Woong Kim, Kyun Heo, Hyun Jung Kim, Sumi Yun, Hye Seung Lee, Ha Gyeong Shin, Hyunbo Shim, Hanjin Yu, Yun-Hee Kim, Sukmook Lee
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 150, Iss , Pp 113051- (2022)
Colorectal cancer (CRC) is one of the life-threatening malignancies worldwide. Thus, novel potential therapeutic targets and therapeutics for the treatment of CRC need to be identified to improve the clinical outcomes of patients with CRC. In this st
Externí odkaz:
https://doaj.org/article/661ee168815b477d9ba998049b21b5b6
Publikováno v:
Translational Oncology, Vol 14, Iss 12, Pp 101232- (2021)
The pancaner molecule CD276 (B7-H3) is an attractive target for antibody based therapy. We identified from a large (1011) phage-displayed single-chain variable fragment (scFv) library, a fully human antibody, B11, which bound with high avidity (KD=0.
Externí odkaz:
https://doaj.org/article/18f0eddf10344c4f99fa93efd581e9e7
Autor:
Ji Hyun Lee, Ji Woong Kim, Ha Rim Yang, Seong-Won Song, Song-Jae Lee, Yeongha Jeon, Anna Ju, Narim Lee, Min-Gu Kim, Minjoo Kim, Kyusang Hwang, Jin Hwan Yoon, Hyunbo Shim, Sukmook Lee
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 6895 (2022)
Small-cell lung cancer (SCLC) is the most aggressive form of lung cancer and the leading cause of global cancer-related mortality. Despite the earlier identification of membrane-proximal cleavage of cell adhesion molecule 1 (CADM1) in cancers, the ro
Externí odkaz:
https://doaj.org/article/8f784c5787dc4c91b85fa816985f44af
Autor:
Behnoush Soltanmohammadi, Somayeh Piri‐Gavgani, Eilnaz Basardeh, Mostafa Ghanei, Masoumeh Azizi, Zabihollah Khaksar, Zahra Sharifzadeh, Farzad Badmasti, Mahdieh Soezi, Abolfazl Fateh, Parisa Azimi, Seyed Davar Siadat, Fahimeh Shooraj, Saeid Bouzari, Mir Davood Omrani, Fatemeh Rahimi‐Jamnani
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 7, Pp n/a-n/a (2021)
Abstract Objectives The increasing prevalence of antibiotic‐resistant Staphylococcus aureus, besides the inadequate numbers of effective antibiotics, emphasises the need to find new therapeutic agents against this lethal pathogen. Methods In this s
Externí odkaz:
https://doaj.org/article/fa048c50d35b40f3a5e39362654fb69b