Replication stress induces POLQ-mediated structural variant formation throughout common fragile sites after entry into mitosis.

Autor: Wilson TE; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. wilsonte@umich.edu.; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. wilsonte@umich.edu., Ahmed S; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Winningham A; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Glover TW; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. glover@umich.edu.; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. glover@umich.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Nov 06; Vol. 15 (1), pp. 9582. Date of Electronic Publication: 2024 Nov 06.

Innovative Tools for DNA Topology Probing in Human Cells Reveal a Build-Up of Positive Supercoils Following Replication Stress at Telomeres and at the FRA3B Fragile Site.

Autor: Ghilain C; CNRS UMR7284/INSERM U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Faculty of Medicine, University Côte d'Azur, 06107 Nice, France., Vidal-Cruchez O; Simpson Querrey Institute, 303 E Superior, Chicago, IL 60611, USA., Joly A; Medical Microbiology and Immunology Department, Faculty of Medicine & Dentistry, University of Alberta, 116 St. and 85 Ave., Edmonton, AB T6G 2R3, Canada., Debatisse M; Gustave Roussy Institute, Sorbonne Université, UPMC, 94805 Villejuif, France., Gilson E; CNRS UMR7284/INSERM U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Faculty of Medicine, University Côte d'Azur, 06107 Nice, France.; Department of Geriatrics, Medical Center on Aging of Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China.; International Research Project in Hematology, Cancer and Aging, Pôle Sino-Français de Recherches en Sciences du Vivant et Génomique, Ruijin Hospital, Shanghai Jiao Tong University School, Shanghai 200025, China.; Department of Genetics, CHU, FHU OncoAge, 06000 Nice, France., Giraud-Panis MJ; CNRS UMR7284/INSERM U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Faculty of Medicine, University Côte d'Azur, 06107 Nice, France.

Publikováno v: Cells [Cells] 2024 Aug 15; Vol. 13 (16). Date of Electronic Publication: 2024 Aug 15.

The RNA tether model for human chromosomal translocation fragile zones.

Autor: Liu D; Institute of Molecular and Translational Medicine (IMTM), and Department of Biochemistry and Molecular Biology, Xi'an Jiaotong University Health Science Center, and Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an, Shaanxi 710061, China., Hsieh CL; USC Norris Comprehensive Cancer Center, Department of Urology, University of Southern California, Los Angeles, CA 90089-9176, USA., Lieber MR; USC Norris Comprehensive Cancer Center, Departments of Pathology and Laboratory Medicine, of Molecular Microbiology and Immunology, of Biochemistry and Molecular Medicine, and in the Section of Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089-9176, USA. Electronic address: lieber@usc.edu.

Publikováno v: Trends in biochemical sciences [Trends Biochem Sci] 2024 May; Vol. 49 (5), pp. 391-400. Date of Electronic Publication: 2024 Mar 14.

Insights into common fragile site instability: DNA replication challenges at DNA repeat sequences.

Autor: Irony-Tur Sinai M; Department of Genetics, The Life Sciences Institute, The Hebrew University, Jerusalem, Israel., Kerem B; Department of Genetics, The Life Sciences Institute, The Hebrew University, Jerusalem, Israel.

Publikováno v: Emerging topics in life sciences [Emerg Top Life Sci] 2023 Dec 14; Vol. 7 (3), pp. 277-287.

Deletion of a pseudogene within a fragile site triggers the oncogenic expression of the mitotic CCSER1 gene.

Autor: Santoliquido BM; Functional Genomics of Cancer Unit, Division of Experimental Oncology, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Frenquelli M; Functional Genomics of Cancer Unit, Division of Experimental Oncology, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy., Contadini C; Unit of Cellular Networks and Molecular Therapeutic Targets, IRCCS-Regina Elena National Cancer Institute, Rome, Italy., Bestetti S; Protein Transport and Secretion Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Gaviraghi M; Functional Genomics of Cancer Unit, Division of Experimental Oncology, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy., Barbieri E; The Wistar Institute, Gene Expression and Regulation Program, Philadelphia, PA, USA., De Antoni A; DNA Metabolism Laboratory, IFOM-The Firc Institute of Molecular Oncology, Milan, Italy., Albarello L; Pathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Amabile A; Vita-Salute San Raffaele University, Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy., Gardini A; The Wistar Institute, Gene Expression and Regulation Program, Philadelphia, PA, USA., Lombardo A; Vita-Salute San Raffaele University, Milan, Italy.; San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy., Doglioni C; Vita-Salute San Raffaele University, Milan, Italy.; Pathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Provero P; Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Department of Neurosciences 'Rita Levi Montalcini,' University of Torino, Turin, Italy., Soddu S; Unit of Cellular Networks and Molecular Therapeutic Targets, IRCCS-Regina Elena National Cancer Institute, Rome, Italy., Cittaro D; Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy., Tonon G; Functional Genomics of Cancer Unit, Division of Experimental Oncology, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy tonon.giovanni@hsr.it.; Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Publikováno v: Life science alliance [Life Sci Alliance] 2021 Jun 29; Vol. 4 (8). Date of Electronic Publication: 2021 Jun 29 (Print Publication: 2021).