Zobrazeno 1 - 10
of 2 768
pro vyhledávání: '"fragile site"'
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 80 (2023)
Cell-free extrachromosomal circular DNA (cf-eccDNA) has been proposed as a promising early biomarker for disease diagnosis, progression and drug response. Its established biomarker features are changes in the number and length distribution of cf-eccD
Externí odkaz:
https://doaj.org/article/3e27c262cd1c4fb9aa4616e0ba60e413
Autor:
Sravan Kodali, Silvia Meyer-Nava, Stephen Landry, Arijita Chakraborty, Juan Carlos Rivera-Mulia, Wenyi Feng
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Common fragile sites (CFSs) are specific regions of all individuals’ genome that are predisposed to DNA double strand breaks (DSBs) and undergo subsequent rearrangements. CFS formation can be induced in vitro by mild level of DNA replication stress
Externí odkaz:
https://doaj.org/article/27dd44996eaf4511b53034ed211719df
Publikováno v:
Current Issues in Molecular Biology, Vol 43, Iss 2, Pp 1133-1141 (2021)
Altered gene expression is a common feature of tumor cells after irradiation. Our previous study showed that this phenomenon is not only an acute response to cytotoxic stress, instead, it was persistently detected in tumor cells that survived 10 Gy i
Externí odkaz:
https://doaj.org/article/4da6563cbe11486b8f2419065034e691
Publikováno v:
Biomolecules & Biomedicine, Vol 22, Iss 3 (2022)
The objective of the study was to investigate the levels of plasma exosome-derived fragile site-associated tumor suppressor (FATS) and evaluate its prognostic predictive ability in ovarian cancer (OC) patients. Exosome-rich fractions were isolated fr
Externí odkaz:
https://doaj.org/article/aeaf4ed8a07b42c28414e33e5c45c191
Publikováno v:
Molecular Cytogenetics, Vol 13, Iss 1, Pp 1-5 (2020)
Abstract Background Small copy number variations confined to the placenta are extremely rare findings in chorionic villus sampling, nonetheless of great clinical importance. To the best of our knowledge, this is the first reported case of confined pl
Externí odkaz:
https://doaj.org/article/2797d56248004a70a46f2aa2f51c3463
Autor:
Ya-Yun Cheng, Ying-Tsen Chou, Feng-Jie Lai, Ming-Shiou Jan, Tsung-Hao Chang, I-Ming Jou, Pei-Shiuan Chen, Jui-Yen Lo, Shiang-Suo Huang, Nan-Shan Chang, Yung-Tsai Liou, Po-Chih Hsu, Hui-Ching Cheng, Yee-Shin Lin, Li-Jin Hsu
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Abstract Human WWOX gene resides in the chromosomal common fragile site FRA16D and encodes a tumor suppressor WW domain-containing oxidoreductase. Loss-of-function mutations in both alleles of WWOX gene lead to autosomal recessive abnormalities in pe
Externí odkaz:
https://doaj.org/article/eb7e53c62cb94d12a058fc878897c937
Autor:
Rajesh Kumar, Gandharva Nagpal, Vinod Kumar, Salman Sadullah Usmani, Piyush Agrawal, Gajendra P. S. Raghava
Publikováno v:
BMC Genomics, Vol 19, Iss S9, Pp 1-8 (2019)
Abstract Background Fragile sites are the chromosomal regions that are susceptible to breakage, and their frequency varies among the human population. Based on the frequency of fragile site induction, they are categorized as common and rare fragile s
Externí odkaz:
https://doaj.org/article/84950b873a334092a8de45ed8a7badbd
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Folate deficiency is associated with a broad range of human disorders, including anemia, fetal neural tube defects, age-associated dementia and several types of cancer. It is well established that a subgroup of rare fragile sites (RFSs) containing ex
Externí odkaz:
https://doaj.org/article/e2e5ed400db84876a69da2b608443428
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 9, Iss 4, Pp n/a-n/a (2021)
Abstract Background A heterozygous natriuretic peptide receptor 2 (NPR2) gene c.2455C>T mutation was identified as a cause of familial idiopathic short stature (ISS). Only two cases with this mutation were reported previously, and the probands with I
Externí odkaz:
https://doaj.org/article/2cba229f1eb8414f995fb7267fabbfce
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