Zobrazeno 1 - 10
of 2 751
pro vyhledávání: '"foxo3"'
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-15 (2024)
Highlights FOXO3 was decreased, while LA and FBXO22 were increased in NSCLC patients. LA promoted cisplatin resistance in NSCLC in vitro and in vivo. SQFZ inhibited LA-induced cisplatin resistance in NSCLC by regulating FOXO3. FBXO22 affected p53 ubi
Externí odkaz:
https://doaj.org/article/b6517b48d25f456d8910d8b45e273a17
Autor:
Huihui Ma, Yujie Jing, Jiangping Zeng, Jiaying Ge, Siqi Sun, Ran Cui, Chunhua Qian, Shen Qu, Hui Sheng
Publikováno v:
Journal of Orthopaedic Translation, Vol 49, Iss , Pp 23-36 (2024)
Background: Muscle atrophy or sarcopenia is the loss of muscle mass and strength and leads to an increased risk of disability and death including osteoporotic fractures. Currently, there are no available clinical biologic agents for the treatment of
Externí odkaz:
https://doaj.org/article/e7076fa13e9c4aa4aedd57cc0b1f1dc6
Autor:
Suttinee Phuagkhaopong, Jiranan Janpattanapichai, Noppavut Sirirak, Phisit Khemawoot, Pornpun Vivithanaporn, Kran Suknuntha
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Boesenbergia rotunda, commonly known as fingerroot, is a medicinal and culinary plant native to the Indochina Peninsula. We found that panduratin A (Pan-A), one of the compounds present in the rhizome extract of fingerroot, inhibited cell pr
Externí odkaz:
https://doaj.org/article/d7c041b7214c405a97c06a0b5f055366
Autor:
Hossein Jalali, Mohammad Reza Mahdavi, Mehrnoush Kosaryan, Ahmad Najafi, Aily Aliasgharian, Ebrahim Salehifar
Publikováno v:
Thalassemia Reports, Vol 14, Iss 3, Pp 71-80 (2024)
HbF induction is an appropriate strategy to ameliorate the severity of β-thalassemia symptoms. Hydroxyurea (HU) is the most common chemical agent introduced as an HbF inducer but responsiveness to HU is variable and the introduction of HbF inducers
Externí odkaz:
https://doaj.org/article/28040da465084f7b966b7a8289701c21
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-26 (2024)
Abstract Background The complex interplay between Sirtuin 1 (SIRT1) and FOXO3 in endometrial cancer (EC) remains understudied. This research aims to unravel the interactions of deacetylase SIRT1 and transcription factor FOXO3 in EC, focusing on their
Externí odkaz:
https://doaj.org/article/4aad2dbcd6584cb3accfbde272f6aae6
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Tibetan pigs are a unique swine strain adapted to the hypoxic environment of the plateau regions in China. The unique mechanisms underlying the adaption by Tibetan pigs, however, are still elusive. Only few studies have investigated hypoxia-
Externí odkaz:
https://doaj.org/article/beadfd63c7934539b06439c608a90b8a
Autor:
Qian Deng, Zining Peng, Fanyu Meng, Wangxin Zeng, Mengyuan Zhu, Nian Liu, Weitian Yan, Jiangyun Peng
Publikováno v:
Autoimmunity, Vol 57, Iss 1 (2024)
This study aimed to identify genes associated with autophagy and potential diagnostic biomarkers by comparing the gene expression profiles of synovial tissues in patients with rheumatoid arthritis (RA) and healthy individuals, aiming to offer new ins
Externí odkaz:
https://doaj.org/article/01822c1394254fe79a9bb55e620007e0
Publikováno v:
Journal of Exercise & Organ Cross Talk, Vol 4, Iss 2, Pp 117-125 (2024)
Resistance exercises and nutritional strategy are the best ways to prevent with age- related muscle atrophy (sarcopenia) by improving the physiological function of skeletal muscle. This study investigated the effect of 8 weeks of Water resistance tra
Externí odkaz:
https://doaj.org/article/4b1c070c3dd0465ea63f78ae97c744af
Akademický článek
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Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 1, Pp 255-269 (2024)
Abstract Background Skeletal muscle atrophy, particularly ageing‐related muscular atrophy such as sarcopenia, is a significant health concern. Despite its prevalence, the underlying mechanisms remain poorly understood, and specific approved medicat
Externí odkaz:
https://doaj.org/article/3d63f85cfc6f4db9963714ce84a7a8b6