Zobrazeno 1 - 10
of 3 415
pro vyhledávání: '"forced degradation"'
Publikováno v:
Results in Chemistry, Vol 11, Iss , Pp 101799- (2024)
Sotorasib is a small molecule inhibitor and approved by USFDA for the treatment of non-small cell lung cancer (NSCLC). In the present study, forced degradation behavior of sotorasib was carried out by utilizing LC-MS/MS technique. As per ICH guidelin
Externí odkaz:
https://doaj.org/article/c3700359cad242d2aa10ea514a87e7ed
Publikováno v:
Journal of Applied Pharmaceutical Research, Vol 12, Iss 2, Pp 27-34 (2024)
Objective: The objective of the study is to create and validate the easy, dependable, accurate, sensitive, and selective RP-HPLC method for estimating Cariprazine HCl in human plasma. Methodology: The sample was prepared using the protein precipitati
Externí odkaz:
https://doaj.org/article/9d0c0835300a4277a57a95113d446a5f
Autor:
Rajvi Agrawal, Rajendra Kotadiya
Publikováno v:
Journal of Taibah University for Science, Vol 18, Iss 1 (2024)
This study developed a stability-indicating RP-HPLC method for quantifying azelnidipine and chlorthalidone in fixed-dose formulations using Analytical Quality by Design (AQbD) principles. A Plackett-Burman design was used for factor screening, follow
Externí odkaz:
https://doaj.org/article/c0d2b5a382ea46ac8cab7945f097c124
Autor:
Shuai Wang, Yanqiu Wang, Zhenzhen Li, Ye Hong, Zhaohui Wang, Jiteng Fan, Qiong Wang, Yuanjie Ge, Xiaofeng Zhao, Guangcun Cheng, Changyan Chen, Yadan Wu, Yayuan Fu
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Precise measurement of the binding activity changes of therapeutic antibodies is important to determine the potential critical quality attributes (CQAs) in developability assessment at the early stage of antibody development. Here, we report a surfac
Externí odkaz:
https://doaj.org/article/19cb036bf9994ae38eb022d448f32c83
Akademický článek
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Publikováno v:
Heliyon, Vol 10, Iss 13, Pp e34066- (2024)
Etrasimod, a novel selective sphingosine-1-phosphate receptor modulator, was recently approved by the U.S. Food and Drug Administration and the European Medicinal Agency for the treatment of moderately to severely active ulcerative colitis in adults.
Externí odkaz:
https://doaj.org/article/b2a2d054d6db43dbaf377f40f305a1e8
Publikováno v:
Acta Pharmaceutica, Vol 73, Iss 4, Pp 709-721 (2023)
Size exclusion chromatography (SEC) has become a powerful tool for analysing size variants of biologic drugs in their native form. Modern SEC can be defined by the use of chromatographic columns packed with sub-3 µm particles, allowing an increase i
Externí odkaz:
https://doaj.org/article/780f2056885f45faa158c1c59dcb6b0e
Autor:
Morenikeji Aina, Fabien Baillon, Romain Sescousse, Noelia M. Sanchez-Ballester, Sylvie Begu, Ian Soulairol, Martial Sauceau
Publikováno v:
Gels, Vol 10, Iss 10, p 665 (2024)
Precision in dosing is crucial for optimizing therapeutic outcomes and preventing overdosing, especially in preterm infants. Traditional manual adjustments to adapt the dose often lead to inaccuracies, contamination risks, and reduced precision. To o
Externí odkaz:
https://doaj.org/article/eafbd6126ad842daa07c2946134fa8aa
Autor:
Alicia Torres-García, Anabel Torrente-López, Jesús Hermosilla, Amparo Hernández, Antonio Salmerón-García, José Cabeza, Natalia Navas
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1222 (2024)
Background/Objectives: Cetuximab, formulated in Erbitux® (5 mg/mL), is a therapeutic monoclonal antibody (mAb) widely used in several cancer treatments. Currently, there is insufficient knowledge about the behavior of cetuximab with regard to the ri
Externí odkaz:
https://doaj.org/article/40b3dbed16664feebb74eb6312e20622
Autor:
Bondili Sesharamsingh, J. Suresh Kumar, I. V. Kasi Viswanath, Gattupalli Subhakara Rao, Venkateswara Rao Anna
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract Background The present study focused to develop a simple and sensitive HPLC method for resolution and estimation process-related impurities of zuclopenthixol and further assessment of forced degradation behavior of zuclopenthixol. Results Th
Externí odkaz:
https://doaj.org/article/1a1a67afa003460d9333974b2f4dfeff