Pharmacometabolomics identifies candidate predictor metabolites of an L‐carnitine treatment mortality benefit in septic shock

Autor: Michael A. Puskarich, Theodore S. Jennaro, Christopher E. Gillies, Charles R. Evans, Alla Karnovsky, Cora E. McHugh, Thomas L. Flott, Alan E. Jones, Kathleen A. Stringer, for the RACE Investigators

Publikováno v: Clinical and Translational Science, Vol 14, Iss 6, Pp 2288-2299 (2021)

Abstract Sepsis‐induced metabolic dysfunction contributes to organ failure and death. L‐carnitine has shown promise for septic shock, but a recent phase II study of patients with vasopressor‐dependent septic shock demonstrated a non‐significa

Externí odkaz: https://doaj.org/article/6ce1ffd631774c4e9df4a19cf077f90d

Optimal treatment of underlying conditions improves rhythm control outcome in atrial fibrillation – Data from RACE 3

Autor: Jan G.P. Tijssen, Bao-Oanh Nguyen, Bastiaan Geelhoed, Harry J.G.M. Crijns, Dirk J. van Veldhuisen, Robert G. Tieleman, Isabelle C. Van Gelder, Race Investigators, Anne H Hobbelt, Michiel Rienstra, Marcelle D. Smit

Publikováno v: American heart journal, 226, 235-239. Mosby Inc.
American Heart Journal, 226, 235-239. MOSBY-ELSEVIER

Atrial fibrillation (AF) is a progressive disease, and maintenance of sinus rhythm is cumbersome. In this analysis of the Routine versus Aggressive risk factor driven upstream rhythm Control for prevention of Early atrial fibrillation in heart failur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e22fc7cfc4787c3943d5d15f6b58e6
https://pure.amc.nl/en/publications/optimal-treatment-of-underlying-conditions-improves-rhythm-control-outcome-in-atrial-fibrillation--data-from-race-3(5e92afbe-a7d2-4fcd-937d-46c08dae5e63).html

Targeted therapy of underlying conditions improves sinus rhythm maintenance in patients with persistent atrial fibrillation

Autor: Jan G.P. Tijssen, Johan Brügemann, Harry J.G.M. Crijns, Raymond Tukkie, Dirk J. van Veldhuisen, Bastiaan Geelhoed, Race Investigators, Marco Alings, Anne H Hobbelt, Robert G. Tieleman, Marcelle D. Smit, Hans L. Hillege, Isabelle C. Van Gelder, Michiel Rienstra

Publikováno v: European Heart Journal, 39(32), 2987-2996. Oxford University Press
European heart journal, 39(32), 2987-2996. Oxford University Press

Aims: Atrial fibrillation (AF) is a progressive disease. Targeted therapy of underlying conditions refers to interventions aiming to modify risk factors in order to prevent AF. We hypothesised that targeted therapy of underlying conditions improves s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24db6220a49f27a9cfb27668da107d3a
https://research.rug.nl/en/publications/36560c88-48d9-4ad0-a6d8-d3381e15fc0c

The Effect of Rate Control on Quality of Life in Patients With Permanent Atrial Fibrillation

Autor: Hans L. Hillege, Eric van Sonderen, Ype S. Tuininga, Race Investigators, Jan G.P. Tijssen, Maarten P. van den Berg, Dirk J. van Veldhuisen, Hessel F. Groenveld, Adelita V. Ranchor, Isabelle C. Van Gelder, Harry J.G.M. Crijns, A. Marco Alings

Publikováno v: Journal of the American College of Cardiology. 58:1795-1803

Objectives The aim of this study was to investigate the influence of rate control on quality of life (QOL). Background The RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) trial showed that lenient rate control is not inferior to s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c520620d416e1ea3360a7155c6ee13
https://doi.org/10.1016/j.jacc.2011.06.055

Lenient vs. strict rate control in patients with atrial fibrillation and heart failure: a post-hoc analysis of the RACE II study

Autor: Bart A. Mulder, M. Alings, Michiel Rienstra, Maarten P. van den Berg, Hessel F. Groenveld, Harry J.G.M. Crijns, Isabelle C. Van Gelder, Jan G.P. Tijssen, Race Investigators, Dirk J. van Veldhuisen, Hans L. Hillege

Publikováno v: European journal of heart failure, 15(11), 1311-1318. Wiley
European Journal of Heart Failure, 15(11), 1311-1318. Wiley
European journal of heart failure, 15(11), 1311-1318. Wiley-Blackwell

AIMS: It is unknown whether lenient rate control is an acceptable strategy in patients with AF and heart failure. We evaluated differences in outcome in patients with AF and heart failure treated with lenient or strict rate control.METHODS AND RESULT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32bff8295060955faab68d70525a341
https://cris.maastrichtuniversity.nl/en/publications/bc634384-746a-471c-b816-1b5725686b98