Zobrazeno 1 - 10
of 266
pro vyhledávání: '"folr1"'
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
BackgroundCerebral folate transport deficiency (CFD) is a rare neurological disease characterized by a deficiency in 5-methyltetrahydrofolate (5-MTHF) in the cerebrospinal fluid, with a normal peripheral total folate level. Late infantile-onset refra
Externí odkaz:
https://doaj.org/article/2b442fed37cc49879cd31e92718a8e14
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 10205 (2024)
Cerebrospinal fluid (CSF) is a fluid critical to brain development, function, and health. It is actively secreted by the choroid plexus, and it emanates from brain tissue due to osmolar exchange and the constant contribution of brain metabolism and a
Externí odkaz:
https://doaj.org/article/c7d254a2fbe043518abd4c8a684a143a
Autor:
Jia Mai, Limei Wu, Ling Yang, Ting Sun, Xiaojuan Liu, Rutie Yin, Yongmei Jiang, Jinke Li, Qintong Li
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/2cbfd403ddad458ba3af76a0eb9262c1
Autor:
Ana Potic, Stefanie Perrier, Tijana Radovic, Svetlana Gavrilovic, Jelena Ostojic, Luan T. Tran, Isabelle Thiffault, Tomi Pastinen, Raphael Schiffmann, Geneviève Bernard
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-17 (2023)
Abstract Background Neurodegeneration due to cerebral folate transport deficiency is a rare autosomal recessive disorder caused by biallelic pathogenic variants in FOLR1. Onset typically occurs in late infancy and is characterized by psychomotor regr
Externí odkaz:
https://doaj.org/article/069bc339519c472a91b38f2db7cff481
Autor:
Shuang Li, Xin Wen, Huaixin Teng, Yunqin Yan, Huili Tong, Bingchen Liu, Shufeng Li, Shuai Shi, Jingyan Su
Publikováno v:
Journal of Functional Foods, Vol 112, Iss , Pp 105965- (2024)
Folic acid (FA) plays multiple roles in many biological processes. Myoblast intakes FA through endocytosis by folate receptor 1 (Folr1), which has vital role in regulating muscle development. However, the mechanism remains unclear. In this study, FA
Externí odkaz:
https://doaj.org/article/9b304b57b17f423bb8bddc85dbab6d9b
Autor:
Jia Mai, Limei Wu, Ling Yang, Ting Sun, Xiaojuan Liu, Rutie Yin, Yongmei Jiang, Jinke Li, Qintong Li
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Epithelial ovarian cancer (EOC) is the deadliest gynecological cancer, and presents a major clinical challenge due to limited treatment options. Folate receptor alpha (FRα), encoded by the FOLR1 gene, is an attractive therapeutically target due to i
Externí odkaz:
https://doaj.org/article/3a8cc88ce92b4cdaaba6973f09e7b0ff
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 35, Iss , Pp 100975- (2023)
Cerebral folate deficiency (CFD) is a rare progressive neurological condition characterized by normal blood folate level and low 5-methyltetrahydrofolate (5-MTHF) levels in the cerebrospinal fluid. Patients present with different neurological finding
Externí odkaz:
https://doaj.org/article/28f55c3e3f154dc7bbdce1376e2c0fa7
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1046 (2024)
Folate receptor α (FR) was discovered many decades ago, along with drugs that target intracellular folate metabolism, such as pemetrexed and methotrexate. Folate is taken up by the cell via this receptor, which also targeted by many cancer agents du
Externí odkaz:
https://doaj.org/article/6c31594351e34a31ab0fbc1203450415
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.