Zobrazeno 1 - 10
of 596
pro vyhledávání: '"fluxomics"'
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-16 (2023)
Abstract Background Production of 3-hydroxypropionic acid (3-HP) through the malonyl-CoA pathway has yielded promising results in Pichia pastoris (Komagataella phaffii), demonstrating the potential of this cell factory to produce this platform chemic
Externí odkaz:
https://doaj.org/article/622f12ff3f7c4e0c9125a790c8a5eb97
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Metabolic fluxes are at the heart of metabolism and growth in any living system. During tuberculosis (TB) infection, the pathogenic Mycobacterium tuberculosis (Mtb) adapts its nutritional behaviour and metabolic fluxes to survive in human macrophages
Externí odkaz:
https://doaj.org/article/863abbb4f1ff48529197dc69f866ad5e
Autor:
Wenyun Lu, Matthew J. McBride, Won Dong Lee, Xi Xing, Xincheng Xu, Xi Li, Anna M. Oschmann, Yihui Shen, Caroline Bartman, Joshua D. Rabinowitz
Publikováno v:
Metabolites, Vol 14, Iss 4, p 184 (2024)
Orbitrap mass spectrometry in full scan mode enables the simultaneous detection of hundreds of metabolites and their isotope-labeled forms. Yet, sensitivity remains limiting for many metabolites, including low-concentration species, poor ionizers, an
Externí odkaz:
https://doaj.org/article/80aade3c2ffe4fca8af497f76819a820
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Publikováno v:
Molecular Horticulture, Vol 2, Iss 1, Pp 1-38 (2022)
Abstract Over the past decade, systems biology and plant-omics have increasingly become the main stream in plant biology research. New developments in mass spectrometry and bioinformatics tools, and methodological schema to integrate multi-omics data
Externí odkaz:
https://doaj.org/article/04c386a4f075477faa0880ab3c0d263d
Autor:
María Matamala Montoya, Gijs J. J. van Slobbe, Jung-Chin Chang, Esther A. Zaal, Celia R. Berkers
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Multiple myeloma (MM) is characterized by the clonal expansion of malignant plasma cells in the bone marrow (BM). MM remains an incurable disease, with the majority of patients experiencing multiple relapses from different drugs. The MM tumor microen
Externí odkaz:
https://doaj.org/article/ba54417d87c24cbeb40cd7ca6d4cb4e2
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
13C metabolic flux analysis (13C-MFA) has emerged as a forceful tool for quantifying in vivo metabolic pathway activity of different biological systems. This technology plays an important role in understanding intracellular metabolism and revealing p
Externí odkaz:
https://doaj.org/article/d8a21a9ef3f141cb829c5312bd651b79
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-17 (2021)
Abstract Background The topology of metabolic networks is both well-studied and remarkably well-conserved across many species. The regulation of these networks, however, is much more poorly characterized, though it is known to be divergent across org
Externí odkaz:
https://doaj.org/article/85ebc6fbb5174ecb931f220841150106
Autor:
Il-Young Kim, Sanghee Park, Yeongmin Kim, Yewon Chang, Cheol Soo Choi, Sang-Hoon Suh, Robert R. Wolfe
Publikováno v:
Endocrinology and Metabolism, Vol 35, Iss 4, Pp 733-749 (2020)
Like other substrates, plasma glucose is in a dynamic state of constant turnover (i.e., rates of glucose appearance [Ra glucose] into and disappearance [Rd glucose] from the plasma) while staying within a narrow range of normal concentrations, a phys
Externí odkaz:
https://doaj.org/article/93559a43d20e4bcdb720f112010bb730
Autor:
Zhengdong Zhang, Zhentao Liu, Yafei Meng, Zhen Chen, Jiayu Han, Yimin Wei, Tie Shen, Yin Yi, Xiaoyao Xie
Publikováno v:
Biotechnology for Biofuels, Vol 13, Iss 1, Pp 1-11 (2020)
Background A precise map of the metabolic fluxome, the closest surrogate to the physiological phenotype, is becoming progressively more important in the metabolic engineering of photosynthetic organisms for biofuel and biomass production. For photosy
Externí odkaz:
https://doaj.org/article/457dd55e891843b1abb682f8bbbe62d2