ARID1A loss sensitizes colorectal cancer cells to floxuridine.

Autor: Xiang C; Guangdong Provincial key laboratory of Gastroenterology, Department of Gastroenterology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China; Comprehensive Medical Treatment Ward, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Wang Z; Guangdong Provincial key laboratory of Gastroenterology, Department of Gastroenterology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China., Yu Y; Guangdong Provincial key laboratory of Gastroenterology, Department of Gastroenterology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China., Han Z; Guangdong Provincial key laboratory of Gastroenterology, Department of Gastroenterology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China., Lu J; Guangdong Provincial key laboratory of Gastroenterology, Department of Gastroenterology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China., Pan L; Guangdong Provincial key laboratory of Gastroenterology, Department of Gastroenterology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China., Zhang X; Guangdong Provincial key laboratory of Gastroenterology, Department of Gastroenterology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China., Wang Z; Guangdong Provincial key laboratory of Gastroenterology, Department of Gastroenterology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China., He Y; Guangdong Provincial key laboratory of Gastroenterology, Department of Gastroenterology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China., Wang K; Guangdong Provincial key laboratory of Gastroenterology, Department of Gastroenterology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China., Peng W; Guangdong Provincial key laboratory of Gastroenterology, Department of Gastroenterology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China., Liu S; Guangdong Provincial key laboratory of Gastroenterology, Department of Gastroenterology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address: sideliu@smu.edu.cn., Song Y; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address: songyj@smu.edu.cn., Wu C; Guangdong Provincial key laboratory of Gastroenterology, Department of Gastroenterology, Nanfang hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address: backkom8788@smu.edu.cn.

Publikováno v: Neoplasia (New York, N.Y.) [Neoplasia] 2024 Dec; Vol. 58, pp. 101069. Date of Electronic Publication: 2024 Oct 16.

Safety and efficacy of adjuvant FOLFOX/FOLFIRI with versus without hepatic arterial infusion of floxuridine in patients following colorectal cancer liver metastasectomy (HARVEST trial): A randomized controlled trial.

Autor: Wang DS; Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Pat Fong W; Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Wen L; Department of Radiation Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China., Cai YY; Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Ren C; Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Wu XJ; Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Zhang TQ; Department of Minimally Invasive & Interventional Therapy, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Cao F; Department of Minimally Invasive & Interventional Therapy, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Zuo MX; Department of Minimally Invasive & Interventional Therapy, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Li BK; Department of Hepatobiliary Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Zheng Y; Department of Hepatobiliary Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Li LR; Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Chen G; Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Ding PR; Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Lu ZH; Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Zhang RX; Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China., Yuan YF; Department of Hepatobiliary Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. Electronic address: yuanyf@sysucc.org.cn., Pan ZZ; Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. Electronic address: panzhzh@sysucc.org.cn., Li YH; Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. Electronic address: liyh@sysucc.org.cn.

Publikováno v: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2025 Jan; Vol. 214, pp. 115154. Date of Electronic Publication: 2024 Nov 30.

Design, Synthesis, and Evaluation of Doxifluridine Derivatives as Nitroreductase-Responsive Anticancer Prodrugs.

Autor: Zhang X; National Key Laboratory of Macromolecular Drug Development and Manufacturing, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, 1 Hunan Street, Liaocheng 252059, China., Dong T; National Key Laboratory of Macromolecular Drug Development and Manufacturing, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, 1 Hunan Street, Liaocheng 252059, China., Li X; National Key Laboratory of Macromolecular Drug Development and Manufacturing, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, 1 Hunan Street, Liaocheng 252059, China., Xu C; National Key Laboratory of Macromolecular Drug Development and Manufacturing, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, 1 Hunan Street, Liaocheng 252059, China., Chen F; National Key Laboratory of Macromolecular Drug Development and Manufacturing, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, 1 Hunan Street, Liaocheng 252059, China., Wang S; National Key Laboratory of Macromolecular Drug Development and Manufacturing, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, 1 Hunan Street, Liaocheng 252059, China., Wang X; National Key Laboratory of Macromolecular Drug Development and Manufacturing, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, 1 Hunan Street, Liaocheng 252059, China.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2024 Oct 27; Vol. 29 (21). Date of Electronic Publication: 2024 Oct 27.

A Modified Floxuridine Reduced-Dose Protocol for Patients with Unresectable Colorectal Liver Metastases Treated with Hepatic Arterial Infusion.

Autor: Schwantes IR; Department of Surgery, Division of Surgical Oncology, Knight Cancer Institute, Oregon Health & Science University (OHSU), Portland, OR, USA., Patel RK; Department of Surgery, Division of Surgical Oncology, Knight Cancer Institute, Oregon Health & Science University (OHSU), Portland, OR, USA., Kardosh A; Department of Medicine, Division of Hematology and Medical Oncology, Knight Cancer Institute, OHSU, Portland, OR, USA., Paxton J; Department of Pharmacy Services, OHSU, Portland, OR, USA., Eil R; Department of Surgery, Division of Surgical Oncology, Knight Cancer Institute, Oregon Health & Science University (OHSU), Portland, OR, USA., Chen EY; Department of Medicine, Division of Hematology and Medical Oncology, Knight Cancer Institute, OHSU, Portland, OR, USA., Rocha FG; Department of Surgery, Division of Surgical Oncology, Knight Cancer Institute, Oregon Health & Science University (OHSU), Portland, OR, USA., Latour E; Biostatistics Shared Resource, Knight Cancer Institute, OHSU, Portland, OR, USA., Pegna G; Department of Medicine, Division of Hematology and Medical Oncology, Knight Cancer Institute, OHSU, Portland, OR, USA., Lopez CD; Department of Medicine, Division of Hematology and Medical Oncology, Knight Cancer Institute, OHSU, Portland, OR, USA., Mayo SC; Department of Surgery, Division of Surgical Oncology, Knight Cancer Institute, Oregon Health & Science University (OHSU), Portland, OR, USA. mayos@ohsu.edu.

Publikováno v: Annals of surgical oncology [Ann Surg Oncol] 2024 Oct; Vol. 31 (10), pp. 6537-6545. Date of Electronic Publication: 2024 Jul 12.

Floxuridine supports UPS independent of germline signaling and proteostasis regulators via involvement of detoxification in C. elegans.

Autor: Dubey AA; Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland., Sarkar A; Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland., Milcz K; Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland., Szulc NA; Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland., Thapa P; Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland., Piechota M; Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland., Serwa RA; IMol Polish Academy of Sciences, Warsaw, Poland., Pokrzywa W; Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland.

Publikováno v: PLoS genetics [PLoS Genet] 2024 Jul 31; Vol. 20 (7), pp. e1011371. Date of Electronic Publication: 2024 Jul 31 (Print Publication: 2024).