Zobrazeno 1 - 10
of 379
pro vyhledávání: '"filamin C"'
Publikováno v:
Journal of Multidisciplinary Healthcare, Vol Volume 17, Pp 5363-5373 (2024)
Jiangtao Dong,1– 4,* Wenjuan Zhang,5,* Qianwen Chen,1– 3,6 Lingfeng Zha1– 3 1Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2
Externí odkaz:
https://doaj.org/article/5dd3e59d62ea4aecb071a281e4558b3f
Autor:
Joyce C. Ohiri, Lisa Dellefave‐Castillo, Garima Tomar, Lisa Wilsbacher, Lubna Choudhury, David Y. Barefield, Dominic Fullenkamp, Anthony M. Gacita, Tanner O. Monroe, Lorenzo Pesce, Malorie Blancard, Lauren Vaught, Alfred L. George, Alexis R. Demonbreun, Megan J. Puckelwartz, Elizabeth M. McNally
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 10 (2024)
Background Many cardiomyopathy‐associated FLNC pathogenic variants are heterozygous truncations, and FLNC pathogenic variants are associated with arrhythmias. Arrhythmia triggers in filaminopathy are incompletely understood. Methods and Results We
Externí odkaz:
https://doaj.org/article/f77896bb0287466494c3807c1849c7e0
Autor:
Shanshan Gao, Lingaonan He, Chi Keung Lam, Matthew R. G. Taylor, Luisa Mestroni, Raffaella Lombardi, Suet Nee Chen
Publikováno v:
Cells, Vol 13, Iss 3, p 278 (2024)
Truncating mutations in filamin C (FLNC) are associated with dilated cardiomyopathy and arrhythmogenic cardiomyopathy. FLNC is an actin-binding protein and is known to interact with transmembrane and structural proteins; hence, the ablation of FLNC i
Externí odkaz:
https://doaj.org/article/c2db8f66f7884a4a917fd613fb1c9724
Autor:
Shunshun Han, Can Cui, Xiyu Zhao, Yao Zhang, Yun Zhang, Jing Zhao, Xiaoxu Shen, Haorong He, Jianping Wang, Menggen Ma, Diyan Li, Qing Zhu, Huadong Yin
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 147-164 (2022)
FilaminC (Flnc) is a member of the actin binding protein family, which is preferentially expressed in the cardiac and skeletal muscle tissues. Although it is known to interact with proteins associated with myofibrillar myopathy, its unique role in sk
Externí odkaz:
https://doaj.org/article/3fa65254ce0d450b88af0d86e5f8e70d
Autor:
Maya Noureddine, Katja Gehmlich
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
The sarcomere is the smallest functional unit of muscle contraction. It is delineated by a protein-rich structure known as the Z-disk, alternating with M-bands. The Z-disk anchors the actin-rich thin filaments and plays a crucial role in maintaining
Externí odkaz:
https://doaj.org/article/80822cf26501441c9ee84a1425acfc5d
Akademický článek
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Publikováno v:
Stem Cell Research, Vol 64, Iss , Pp 102928- (2022)
Dilated cardiomyopathy (DCM) is a heterogeneous cardiac disorder characterized by left ventricular dilatation and dysfunction. Mutations in dozens of cardiac genes have been connected to the development of DCM including the filamin C gene (FLNC). We
Externí odkaz:
https://doaj.org/article/10557724b66545a1a2b9bf463d68606e
Akademický článek
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Autor:
Shashipavan Chillappagari, Julian Schwarz, Vidyasagar Kesireddy, Jessica Knoell, Martina Korfei, Konrad Hoetzenecker, M. Lienhard Schmitz, Christian Behl, Saverio Bellusci, Andreas Guenther, Poornima Mahavadi
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 7, Pp n/a-n/a (2022)
Abstract Background Exaggerated fibroblast proliferation is a well‐known feature in idiopathic pulmonary fibrosis (IPF) which may be – in part – due to insufficient autophagy, a lysosome dependent cellular surveillance pathway. Bcl2‐associate
Externí odkaz:
https://doaj.org/article/6f9ebcc8bb3a4739be193fb80c667671
Autor:
Daniele Velardo, Maria Grazia D'Angelo, Andrea Citterio, Elena Panzeri, Laura Napoli, Claudia Cinnante, Maurizio Moggio, Giacomo Pietro Comi, Dario Ronchi, Maria Teresa Bassi
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Filamin C is a large dimeric actin-binding protein, most prevalent in skeletal and cardiac muscle Z-discs, where it participates in sarcomere mechanical stabilization and intracellular signaling, interacting with numerous binding partners. Dominant h
Externí odkaz:
https://doaj.org/article/4218c73b2bb04332b9741ddf8f4eeb8d