Zobrazeno 1 - 10
of 11 351
pro vyhledávání: '"fibroblast growth factor receptor"'
Autor:
Irene Testi, Giulia Claire Giudice, Giuseppe Salfi, Martino Pedrani, Sara Merler, Fabio Turco, Luigi Tortola, Ursula Vogl
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 6, Pp 1326-1364 (2024)
Advanced urothelial carcinoma (aUC) has a dismal prognosis, with a 5-year survival rate of approximately 10%. Platinum-based chemotherapy has been the backbone of the first-line treatment of aUC for over 40 years. Only in the last decade, the treatme
Externí odkaz:
https://doaj.org/article/50345d19217b432891d671f63e69aa3f
Publikováno v:
Jichu yixue yu linchuang, Vol 44, Iss 11, Pp 1530-1537 (2024)
Objective To investigate the effect of fibroblast growth factor receptor 3 (FGFR3) on articular cartilage superficial zone cells (SPZCs). Methods C57 mice were randomly divided into two groups: a sham operated group (sham group) and a group of surgic
Externí odkaz:
https://doaj.org/article/52b13288f66c43caa9880837c992ef7c
Autor:
Roberto Alva‐Ruiz, Ryan D. Watkins, Jennifer L. Tomlinson, Jennifer A. Yonkus, Amro M. Abdelrahman, Caitlin B. Conboy, Erik Jessen, Nathan W. Werneburg, Hendrien Kuipers, Jack W. Sample, Gregory J. Gores, Sumera I. Ilyas, Mark J. Truty, Rory L. Smoot
Publikováno v:
FEBS Open Bio, Vol 14, Iss 11, Pp 1873-1887 (2024)
Cholangiocarcinoma (CCA) is a highly aggressive form of liver cancer and is an increasing cause of cancer‐related death worldwide. Despite its increasing incidence globally and alarming mortality, treatment options for CCA have largely remained unc
Externí odkaz:
https://doaj.org/article/c06dce51bdf6443f86bb9d8ffcc1a4dc
Autor:
Kuan-Chang Lai, Ming-Huang Chen
Publikováno v:
Journal of Cancer Research and Practice, Vol 11, Iss 3, Pp 114-117 (2024)
Patients with advanced intrahepatic cholangiocarcinoma (iCCA) have a poor prognosis. Recent advances in molecular profiling offer hope by enabling targeted treatment for those with specific mutations, potentially increasing survival rates. Pemigatini
Externí odkaz:
https://doaj.org/article/90538e2a2a7440e9bc9dabf9b3c663b7
Publikováno v:
Animal Cells and Systems, Vol 28, Iss 1, Pp 216-227 (2024)
ABSTRACTTyrosine kinase inhibitors (TKIs) have emerged as a potential treatment strategy for glioblastoma multiforme (GBM). However, their efficacy is limited by various drug resistance mechanisms. To devise more effective treatments for GBM, genetic
Externí odkaz:
https://doaj.org/article/26d79f4d4ab7426ab2628d192cc2c124
Autor:
Anas Shamsi, Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Moyad Shahwan, Mohammad Furkan, Rizwan Hasan Khan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Developing new therapeutic strategies to target specific molecular pathways has become a primary focus in modern drug discovery science. Fibroblast growth factor receptor 2 (FGFR2) is a critical signaling protein involved in various cellular
Externí odkaz:
https://doaj.org/article/949016c0b9af465587dfc868099a92e8
Autor:
Dereje E. Bogale
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Bladder cancer is one of the most frequently occurring cancers worldwide. At diagnosis, 75% of urothelial bladder cancer cases have non-muscle invasive bladder cancer while 25% have muscle invasive or metastatic disease. Aberrantly activated
Externí odkaz:
https://doaj.org/article/0f39e133ecfe4951bd109a6ff367534c
Autor:
Heng-Zhen Li, Jing-lve Zhang, Dong-Liang Yuan, Wen-Qing Xie, Christoph H. Ladel, Ali Mobasheri, Yu-Sheng Li
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-23 (2024)
Abstract Fibroblast growth factor (FGF) signaling encompasses a multitude of functions, including regulation of cell proliferation, differentiation, morphogenesis, and patterning. FGFs and their receptors (FGFR) are crucial for adult tissue repair pr
Externí odkaz:
https://doaj.org/article/4ceb09a5a6724476871ca3feebd558f8
Autor:
I. Tsimafeyeu, P. Makhov, D. Ovcharenko, J. Smith, Y. Khochenkova, A. Olshanskaya, D. Khochenkov
Publikováno v:
Immuno-Oncology and Technology, Vol 23, Iss , Pp 100725- (2024)
Background: Fibroblast growth factor receptor 1 (FGFR1) plays a crucial role in carcinogenesis. Exploring the combination of the novel humanized monoclonal anti-FGFR1 antibody OM-RCA-01 and immunotherapy was intriguing due to involvement of FGFR1 in
Externí odkaz:
https://doaj.org/article/43c022b902de482aa5ac5965b28157dd
Autor:
Fataneh Majlessipour, Gaohui Zhu, Nicole Baca, Meenasri Kumbaji, Vivian Hwa, Moise Danielpour
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e30887- (2024)
Fibroblast growth factors and their receptors (FGFR) have major roles in both human growth and oncogenesis. In adults, therapeutic FGFR inhibitors have been successful against tumors that carry somatic FGFR mutations. In pediatric patients, trials te
Externí odkaz:
https://doaj.org/article/0f0762d9013c4405b5bd7cf9533b6c3f