Zobrazeno 1 - 10
of 3 884
pro vyhledávání: '"fibroblast‐like synoviocytes"'
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Background Osteoarthritis (OA) is the most common motor system disease in older people, characterized by a high incidence and significant social and economic burden. Women have a higher risk of OA, more severe clinical symptoms, and a higher
Externí odkaz:
https://doaj.org/article/1b3a2b61f63141e5ac8242a63aafd670
Publikováno v:
Jichu yixue yu linchuang, Vol 44, Iss 10, Pp 1407-1413 (2024)
Objective To investigate the regulatory effect of small interfering RNA (siRNA) silencing zinc finger protein A20 on pyroptosis of rheumatoid arthritis(RA) fibroblast-like synoviocytes (HFLS-RA). Methods Human FLS-RA cell line MH7A cells were cultiva
Externí odkaz:
https://doaj.org/article/125fcc2b554a4cb9a556e227f3f3d3ec
Autor:
Ye Lin, Yuanyuan Tang, Ouyang Yi, Junping Zhu, Zhaoli Su, Gejing Li, Hua Zhou, Liang Liu, Bin Liu, Xiong Cai
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract The characteristic features of the rheumatoid arthritis (RA) microenvironment are synovial inflammation and hyperplasia. Therefore, there is a growing interest in developing a suitable therapeutic strategy for RA that targets the synovial ma
Externí odkaz:
https://doaj.org/article/214018d85a3d46c698ba0066b3dc744e
Autor:
Junping Zhu, Ye Lin, Gejing Li, Yini He, Zhaoli Su, Yuanyuan Tang, Ye Zhang, Qian Xu, Zhongliu Yao, Hua Zhou, Bin Liu, Xiong Cai
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 14, Iss 11, Pp 100981- (2024)
Rheumatoid arthritis (RA) is a prevalent autoimmune disease characterized by chronic inflammation and excessive proliferation of the synovium. Currently, treatment options focus on either reducing inflammation or inhibiting synovial hyperplasia. Howe
Externí odkaz:
https://doaj.org/article/fee8d561f4854f4993385792df02aab3
Autor:
Yi Shen, Ronghua Bao, Xinyuan Ye, Heming Li, Yiqi Sun, Qiuru Ren, Jinman Du, Tianwen Ye, Quanlong Zhang, Qiming Zhao, Ting Han, Luping Qin, Qiaoyan Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundMorinda officinalis iridoid glycosides (MOIG) showed potential benefits in the treatment of rheumatoid arthritis (RA), but their exact mechanism has yet to be explored.PurposeTo evaluate the effects of MOIG on RA, and explore the potential
Externí odkaz:
https://doaj.org/article/c1537f03696f4b5b9b75f6b256cb23c4
Publikováno v:
BMC Immunology, Vol 25, Iss 1, Pp 1-9 (2024)
Abstract Background Rheumatoid arthritis (RA) is a chronic immune system disease with a high disability rate threatening the living quality of patients. Identifying potential biomarkers for RA is of necessity to improve the prevention and management
Externí odkaz:
https://doaj.org/article/ba604e7f04064d1ca0ff1e72a11712d5
Autor:
Mohammadreza Khomeijani-Farahani, Jafar karami, Elham Farhadi, Samaneh Soltani, Ali-Akbar Delbandi, Mehdi Shekarabi, Mohammad Naghi Tahmasebi, Arash Sharafat Vaziri, Ahmadreza Jamshidi, Mahdi Mahmoudi, Masoomeh Akhlaghi
Publikováno v:
Advances in Rheumatology, Vol 64, Iss 1, Pp 1-9 (2024)
Abstract Background Fibroblast-like synoviocytes (FLSs) are involved in osteoarthritis (OA) pathogenesis through pro-inflammatory cytokine production. TAK-242, a TLR4 blocker, has been found to have a significant impact on the gene expression profile
Externí odkaz:
https://doaj.org/article/a3a734a71f8d44d693aa3681ec0fccf6
Autor:
Sofie Falkenløve Madsen, Sarah Spliid Madsen, Alexander Scheller Madrid, Mikkel Rathsach Andersen, Anne-Christine Bay-Jensen, Christian S. Thudium
Publikováno v:
Translational Medicine Communications, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract Background We aimed to investigate the development of synovial fibrosis in vitro and how the fibrosis can be halted. Synovial fibrosis causes joint stiffness in arthritic diseases. The pathway of the fibrotic growth factor, transforming grow
Externí odkaz:
https://doaj.org/article/5891c057397349e08699b0e2b5ee9800
Autor:
Hongyan Qian, Chaoqiong Deng, Shiju Chen, Xinwei Zhang, Yan He, Jingying Lan, Aodi Wang, Guixiu Shi, Yuan Liu
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-15 (2024)
Abstract Fibroblast-like synoviocytes (FLSs) play a central role in RA pathogenesis and are the main cellular component in the inflamed synovium of patients with rheumatoid arthritis (RA). FLSs are emerging as promising new therapeutic targets in RA.
Externí odkaz:
https://doaj.org/article/2d84afc23e65472eb712edf206e496aa
Publikováno v:
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 32, Iss 1, Pp 7396-7404 (2024)
Introduction: Fibroblast-like synoviocytes (FLS), also known as synovial fibroblasts or type B synoviocytes, are the primary cells responsible for the structure of the synovial lining. They are crucial for the formation of a healthy, organized synovi
Externí odkaz:
https://doaj.org/article/06ee39ba068a4264828fc65bb17d0b96