Výsledky vyhledávání - "fibrillogenesi"

Impact of a Single Point Mutation on the Antimicrobial and Fibrillogenic Properties of Cryptides from Human Apolipoprotein B

Autor: Rocco Di Girolamo, Giovanni Smaldone, Angela Arciello, Mariano Rumolo, Pompea Del Vecchio, Angela Cesaro, Eugenio Notomista, Rosa Gaglione, Rosario Oliva, Emilia Pedone, Maria De Luca, Luigi Petraccone

Publikováno v: Pharmaceuticals, Vol 14, Iss 631, p 631 (2021)
Pharmaceuticals
Volume 14
Issue 7

Host defense peptides (HDPs) are gaining increasing interest, since they are endowed with multiple activities, are often effective on multidrug resistant bacteria and do not generally lead to the development of resistance phenotypes. Cryptic HDPs hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f6bdad985c56e2911e0b20b3488332
https://www.mdpi.com/1424-8247/14/7/631

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Effect of Tetracyclines on the Dynamics of Formation and Destructuration of β2-Microglobulin Amyloid Fibrils*♦

Autor: Luca Codutti, Gennaro Esposito, Sofia Giorgetti, Monica Bucciantini, Lino Colombo, Monica Stoppini, Federico Fogolari, Sara Raimondi, Mario Salmona, Ada De Luigi, Riccardo Porcari, Alessandra Corazza, Massimo Stefani, Vittorio Bellotti, Palma Mangione, Alessandra Gliozzi, Annalisa Relini, Katiuscia Pagano

The discovery of methods suitable for the conversion in vitro of native proteins into amyloid fibrils has shed light on the molecular basis of amyloidosis and has provided fundamental tools for drug discovery. We have studied the capacity of a small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b79793a800720ea3c5e8c444fb768ac
https://europepmc.org/articles/PMC3023509/

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A Novel Retro-Inverso Peptide Inhibitor Reduces Amyloid Deposition, Oxidation and Inflammation and Stimulates Neurogenesis in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease

Autor: Vadivel Parthsarathy, Elisa Salvati, Christian Hölscher, David Allsop, Mark Taylor, Paula McClean, Claire Tinker, Oleg Kolosov, Glynn Jones, Massimo Masserini, Maria Gregori

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e54769 (2013)
PLoS ONE

Previously, we have developed a retro-inverso peptide inhibitor (RI-OR2, rGffvlkGr) that blocks the in vitro formation and toxicity of the Aβ oligomers which are thought to be a cause of neurodegeneration and memory loss in Alzheimer's disease. We h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e937297fcfabc926cefd2d62877453c
https://doi.org/10.1371/journal.pone.0054769

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