Zobrazeno 1 - 10
of 1 498
pro vyhledávání: '"fgf19"'
Autor:
Toshiyuki Tanaka, Tomoki Motegi, Misaki Mori, Nanami Sumikawa, Kaito Maeda, Yasumasa Iimori, Hideo Akiyoshi
Publikováno v:
BMC Research Notes, Vol 17, Iss 1, Pp 1-3 (2024)
Abstract Objectives Unresectable canine hepatocellular carcinoma (HCC) has limited nonsurgical treatment options. Sorafenib is a targeted therapy for unresectable canine HCC. However, there are limited reports on the expression of target genes. There
Externí odkaz:
https://doaj.org/article/314b38b481e14b00833243a853c1f4c9
Akademický článek
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Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
ObjectiveTo assess the potential value of fibroblast growth factor 19 (FGF19) as a predictor of gastrointestinal (GI) dysfunction in patients with sepsis.MethodsA prospective study was conducted, and 209 patients who were diagnosed with sepsis and ad
Externí odkaz:
https://doaj.org/article/b40934356baf43d688311f6aa88f0607
Autor:
Yoo-Young Lee, Ji-Yoon Ryu, Young-Jae Cho, Ju-Yeon Choi, Jung-Joo Choi, Chel Hun Choi, Jason K. Sa, Jae Ryoung Hwang, Jeong-Won Lee
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background The FGF/FGFR signaling pathway plays a critical role in human cancers. We analyzed the anti-tumor effect of AZD4547, an inhibitor targeting the FGF/FGFR pathway, in epithelial ovarian cancer (EOC) and strategies on overcoming AZD4
Externí odkaz:
https://doaj.org/article/bb0f0de1ef464888a1ad40fee1caaf67
Autor:
Lu Shi, Tiantian Zhao, Lei Huang, Xiaomin Pan, Tianzhen Wu, Xin Feng, Taoli Chen, Jiamin Wu, Jianlou Niu
Publikováno v:
BMC Biotechnology, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Background The major safety concern of the clinical application of wild type FGF19 (FGF19WT) emerges given that its extended treatment causes hepatocellular carcinoma. Therefore, we previously generated a safer FGF19 variant - FGF19ΔKLB, wh
Externí odkaz:
https://doaj.org/article/752e3deb8380431b907f6acfa6bbc775
Akademický článek
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Publikováno v:
Cancer Medicine, Vol 12, Iss 7, Pp 7762-7771 (2023)
Abstract Objective Inhibition of fibroblast growth factor (FGF) 19‐FGF Receptor 4 (FGFR4) signaling demonstrates potent anticancer activity. EVER4010001 is a highly selective FGFR4 inhibitor and pembrolizumab is approved for the treatment of severa
Externí odkaz:
https://doaj.org/article/9732d0e461474757a49f0ef0b2c700f5
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Anxiety disorder is a prevalent neuropsychiatric disorder that afflicts 7.3%~28.0% of the world’s population. Bile acids are synthesized by hepatocytes and modulate metabolism via farnesoid X receptor (FXR), G protein-coupled receptor (TGR5), etc.
Externí odkaz:
https://doaj.org/article/ff00677e28a34ffbb50d82d5fc4620d3
Autor:
Shiyi Kan, Caixia Pi, Li Zhang, Daimo Guo, Zhixing Niu, Yang Liu, Mengmeng Duan, Xiahua Pu, Mingru Bai, Chenchen Zhou, Demao Zhang, Jing Xie
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Fibroblast growth factor 19 (FGF19) is recognized to play an essential role in cartilage development and physiology, and has emerged as a potential therapeutic target for skeletal metabolic diseases. However, FGF19-mediated cellular behavior
Externí odkaz:
https://doaj.org/article/586c013bcbad4eaca10fdd903c4e108a
Autor:
Yanjun Zhang, Guimei Li, Feifei Xiao, Bang Wang, Jianchang Li, Xiuhong Jia, Yan Sun, Hongye Chen
Publikováno v:
BMC Pediatrics, Vol 23, Iss 1, Pp 1-8 (2023)
Abstract Background Fibroblast growth factor 19 (FGF19) takes part in maintaining the balance of glycolipids and may be involved in complications of type 1 diabetes(T1D) in children. This study aimed at at evaluating the relationship among the levels
Externí odkaz:
https://doaj.org/article/94e65b1fdb2c4a49911d7923d7adfd28