Zobrazeno 1 - 10
of 117
pro vyhledávání: '"ferdinando di cunto"'
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Autosomal recessive primary microcephaly (MCPH) is a constellation of disorders that share significant brain size reduction and mild to moderate intellectual disability, which may be accompanied by a large variety of more invalidating clinical signs.
Externí odkaz:
https://doaj.org/article/eba3b53acbe049138e6f80c46db4f6f2
Autor:
Gianmarco Pallavicini, Giorgia Iegiani, Roberta Parolisi, Alessia Ferraro, Francesca Garello, Valeria Bitonto, Enzo Terreno, Marta Gai, Ferdinando Di Cunto
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionMedulloblastoma (MB), the most common malignant pediatric brain tumor, is currently treated with surgery followed by radiation and chemotherapy, which is accompanied by severe side effects, raising the need for innovative therapies. Disru
Externí odkaz:
https://doaj.org/article/b69b2d5fc6214afabaf4d4b8c430de8f
Autor:
Enrica Boda, Martina Lorenzati, Roberta Parolisi, Brian Harding, Gianmarco Pallavicini, Luca Bonfanti, Amanda Moccia, Stephanie Bielas, Ferdinando Di Cunto, Annalisa Buffo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here the authors show that, depending on their distinct developmental origins and ability to counteract oxidative stress, dorsal and ventral oligodendrocyte progenitor cells of the postnatal mouse brain are differentially vulnerable to DNA damage.
Externí odkaz:
https://doaj.org/article/cd99364e8ab742c7bbfc3f0475298e10
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-11 (2021)
Abstract Medulloblastoma (MB) and gliomas are the most frequent high-grade brain tumors (HGBT) in children and adulthood, respectively. The general treatment for these tumors consists in surgery, followed by radiotherapy and chemotherapy. Despite the
Externí odkaz:
https://doaj.org/article/085174c9dc964093a29e736eb4909825
Autor:
Angelisa Frasca, Eleonora Spiombi, Michela Palmieri, Elena Albizzati, Maria Maddalena Valente, Anna Bergo, Barbara Leva, Charlotte Kilstrup‐Nielsen, Federico Bianchi, Valerio Di Carlo, Ferdinando Di Cunto, Nicoletta Landsberger
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 6, Pp 1-18 (2020)
Abstract Mutations in MECP2 cause several neurological disorders of which Rett syndrome (RTT) represents the best‐defined condition. Although mainly working as a transcriptional repressor, MeCP2 is a multifunctional protein revealing several activi
Externí odkaz:
https://doaj.org/article/b33103f72f62419ba99b856dddd50402
Autor:
Matilde Ghibaudi, Marina Boido, Darrell Green, Elena Signorino, Gaia Elena Berto, Soraya Pourshayesteh, Archana Singh, Ferdinando Di Cunto, Tamas Dalmay, Alessandro Vercelli
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Spinal cord injury (SCI) affects 6 million people worldwide with no available treatment. Despite research advances, the inherent poor regeneration potential of the central nervous system remains a major hurdle. Small RNAs (sRNAs) 19–33 nucleotides
Externí odkaz:
https://doaj.org/article/93388acd76264c3a9a0e3d2e09aeab2d
Publikováno v:
Frontiers in Physics, Vol 8 (2020)
Space agencies are working to establish a permanent human presence on the moon and to reach Mars within the next few decades. In these missions, astronaut crew members will be exposed to moderate doses of the highly energetic particles that compose g
Externí odkaz:
https://doaj.org/article/795993d44be54c048b9b221416fce7c7
Autor:
Federico Tommaso Bianchi, Chiara Tocco, Gianmarco Pallavicini, Yifan Liu, Fiammetta Vernì, Chiara Merigliano, Silvia Bonaccorsi, Nadia El-Assawy, Lorenzo Priano, Marta Gai, Gaia Elena Berto, Alessandra Maria Adelaide Chiotto, Francesco Sgrò, Alessia Caramello, Laura Tasca, Ugo Ala, Francesco Neri, Salvatore Oliviero, Alessandro Mauro, Stephan Geley, Maurizio Gatti, Ferdinando Di Cunto
Publikováno v:
Cell Reports, Vol 18, Iss 7, Pp 1674-1686 (2017)
Mutations in citron (CIT), leading to loss or inactivation of the citron kinase protein (CITK), cause primary microcephaly in humans and rodents, associated with cytokinesis failure and apoptosis in neural progenitors. We show that CITK loss induces
Externí odkaz:
https://doaj.org/article/439c9fc4b61d4ba8b1c56e6b173b51f6
Autor:
Alessandra Maria Adelaide Chiotto, Martina Migliorero, Gianmarco Pallavicini, Federico Tommaso Bianchi, Marta Gai, Ferdinando Di Cunto, Gaia Elena Berto
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Down Syndrome (DS) is the most common genetic disorder associated with intellectual disability (ID). Excitatory neurons of DS patients and mouse models show decreased size of dendritic field and reduction of spine density. Whether these defects are c
Externí odkaz:
https://doaj.org/article/aabf894aa3494c0a8c76b944919d37da
Autor:
Romina Burla, Mattia La Torre, Giorgia Zanetti, Alex Bastianelli, Chiara Merigliano, Simona Del Giudice, Alessandro Vercelli, Ferdinando Di Cunto, Marina Boido, Fiammetta Vernì, Isabella Saggio
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Epilepsy is a complex clinical condition characterized by repeated spontaneous seizures. Seizures have been linked to multiple drivers including DNA damage accumulation. Investigation of epilepsy physiopathology in humans imposes ethical and practica
Externí odkaz:
https://doaj.org/article/2d529d953eb344e79f1020c24bcf3ea6