A nanoencapsulated oral formulation of fenretinide promotes local and metastatic breast cancer dormancy in HER2/neu transgenic mice.

Autor: De Angelis ML; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy., Francescangeli F; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy., Aricò E; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy., Verachi P; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy., Zucchetti M; Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Matteo C; Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Petricci E; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy., Pilozzi E; Department of Clinical and Molecular Medicine, Unit of Pathologic Anatomy Morphologic and Molecular, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy., Orienti I; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy., Boe A; Cytometry Unit, Core Facilities, Istituto Superiore di Sanità, Rome, Italy., Eramo A; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy., Rossi R; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy., Corati T; Department of Clinical and Molecular Medicine, Unit of Pathologic Anatomy Morphologic and Molecular, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy., Macchia D; Center of Animal Research and Welfare, Istituto Superiore di Sanità, Rome, Italy., Pacca AM; Center of Animal Research and Welfare, Istituto Superiore di Sanità, Rome, Italy., Zeuner A; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy. ann.zeuner@iss.it., Baiocchi M; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy. marta.baiocchi@iss.it.

Publikováno v: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Nov 05; Vol. 43 (1), pp. 296. Date of Electronic Publication: 2024 Nov 05.

A nanoencapsulated oral formulation of fenretinide promotes local and metastatic breast cancer dormancy in HER2/neu transgenic mice

Autor: Maria Laura De Angelis, Federica Francescangeli, Eleonora Aricò, Paola Verachi, Massimo Zucchetti, Cristina Matteo, Elena Petricci, Emanuela Pilozzi, Isabella Orienti, Alessandra Boe, Adriana Eramo, Rachele Rossi, Tiberio Corati, Daniele Macchia, Anna Maria Pacca, Ann Zeuner, Marta Baiocchi

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)

Abstract Background Prevention and treatment of metastatic breast cancer (BC) is an unmet clinical need. The retinoic acid derivative fenretinide (FeR) was previously evaluated in Phase I-III clinical trials but, despite its excellent tolerability an

Externí odkaz: https://doaj.org/article/5942086ad2e94655b5f65ad924876c24

Antiproliferative and Morphological Effects of Fenretinide Lipid Nanosystems in Colon Adenocarcinoma Cells.

Autor: Anconelli, Lorenzo¹ (AUTHOR) lorenzo.anconelli3@unibo.it, Farioli, Francesca¹ (AUTHOR) francesca.farioli@studio.unibo.it, Lodeserto, Pietro² (AUTHOR) pietro.lodeserto@ptvonline.it, Andreadi, Aikaterini² (AUTHOR) andreadi@med.uniroma2.it, Borsetti, Francesca^1,3 (AUTHOR) francesca.borsetti@unibo.it, Voltattorni, Manuela¹ (AUTHOR) manuela.voltattorni@unibo.it, Galassi, Lucrezia¹ (AUTHOR) lucrezia.galassi2@unibo.it, Rossi, Martina¹ (AUTHOR) martina.rossi12@unibo.it, Farruggia, Giovanna^1,3,4 (AUTHOR) giovanna.farruggia@unibo.it, Blasi, Paolo^1,3 (AUTHOR) p.blasi@unibo.it, Orienti, Isabella¹ (AUTHOR) p.blasi@unibo.it

Publikováno v: Pharmaceutics. Nov2024, Vol. 16 Issue 11, p1421. 17p.

Growth modulatory effects of fenretinide encompass keratinocyte terminal differentiation: a favorable outcome for oral squamous cell carcinoma chemoprevention.

Autor: Wang D; Division of Oral Maxillofacial Pathology, College of Dentistry, The Ohio State University, Columbus, OH, USA., Pei P; Division of Oral Maxillofacial Pathology, College of Dentistry, The Ohio State University, Columbus, OH, USA., Shea F; Division of Oral Maxillofacial Pathology, College of Dentistry, The Ohio State University, Columbus, OH, USA., Spinney R; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA., Chang A; Department of Chemical Engineering, Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Material Science and Engineering, Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Macromolecular Science and Engineering, Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA., Lahann J; Department of Chemical Engineering, Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Material Science and Engineering, Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Department of Macromolecular Science and Engineering, Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA., Mallery SR; Division of Oral Maxillofacial Pathology, College of Dentistry, The Ohio State University, Columbus, OH, USA.; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.

Publikováno v: Carcinogenesis [Carcinogenesis] 2024 Jun 10; Vol. 45 (6), pp. 436-449.

Attempts to Improve Lipophilic Drugs' Solubility and Bioavailability: A Focus on Fenretinide.

Autor: Alfei, Silvana¹ (AUTHOR) silvana.alfei@unige.it, Zuccari, Guendalina² (AUTHOR) guendalina.zuccari@unige.it

Publikováno v: Pharmaceutics. May2024, Vol. 16 Issue 5, p579. 25p.