Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios

Autor: Miranda L. Wilson, Shannon N. Romano, Nitya Khatri, Devora Aharon, Yulong Liu, Odelya H. Kaufman, Bruce W. Draper, Florence L. Marlow

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Reproductive success relies on proper establishment and maintenance of biological sex. In many animals, including mammals, the primary gonad is initially ovary biased. We previously showed the RNA binding protein (RNAbp), Rbpms2, is required

Externí odkaz: https://doaj.org/article/3ae1f6e7f3fb4706a7fdf24731f672c3

Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component, Mios.

Autor: Wilson ML; Department of Cell, Developmental, and Regenerative Biology. Icahn School of Medicine at Mount Sinai. One Gustave L. Levy Place Box 1020 New York, NY 10029-6574., Romano SN; Department of Cell, Developmental, and Regenerative Biology. Icahn School of Medicine at Mount Sinai. One Gustave L. Levy Place Box 1020 New York, NY 10029-6574., Khatri N; Department of Cell, Developmental, and Regenerative Biology. Icahn School of Medicine at Mount Sinai. One Gustave L. Levy Place Box 1020 New York, NY 10029-6574., Aharon D; Department of Cell, Developmental, and Regenerative Biology. Icahn School of Medicine at Mount Sinai. One Gustave L. Levy Place Box 1020 New York, NY 10029-6574., Liu Y; Department of Molecular and Cellular Biology. University of California. 1 Shields Ave, Davis, CA 95616., Kaufman OH; Department of Developmental and Molecular Biology. Albert Einstein College of Medicine. 1300 Morris Park Avenue, Bronx, NY 10461., Draper BW; Department of Molecular and Cellular Biology. University of California. 1 Shields Ave, Davis, CA 95616., Marlow FL; Department of Cell, Developmental, and Regenerative Biology. Icahn School of Medicine at Mount Sinai. One Gustave L. Levy Place Box 1020 New York, NY 10029-6574.; Department of Developmental and Molecular Biology. Albert Einstein College of Medicine. 1300 Morris Park Avenue, Bronx, NY 10461.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 25. Date of Electronic Publication: 2024 Jan 25.

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Instructing Mouse Germ Cells to Adopt a Female Fate

Autor: Cassy Spiller, Josephine Bowles

Publikováno v: Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation.

Background: Germ cells are critical for the survival of our species. They are the only cells that undergo meiosis – the reductive form of cell division that is necessary for genetic reassortment of chromosomes and production of the haploid gametes,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2309935dc2653c5537d82fc7282eddb
https://pubmed.ncbi.nlm.nih.gov/35320803

CBX2 is required during male sex determination to repress female fate at bivalent loci

Autor: Danielle Maatouk, Yi-Tzu Lin, Isabella Salamone, Blanche Capel, Christopher R. Futtner, Sara Alexandra Garcia-Moreno

The epigenetic mechanisms that regulate the male vs. female cell-fate decision in the mammalian bipotential gonad are poorly understood. In this study, we developed a quantitative genome-wide profile of H3K4me3 and H3K27me3 in isolated XY and XX gona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88fcd20a6f5893f53186aed17d50192d