Zobrazeno 1 - 10
of 1 015
pro vyhledávání: '"fcγ"'
Autor:
Omar S. Qureshi, Emma J. Sutton, Rosemary F. Bithell, Shauna M. West, Rona M. Cutler, Gillian McCluskey, Graham Craggs, Asher Maroof, Nicholas M. Barnes, David P. Humphreys, Stephen Rapecki, Bryan J. Smith, Anthony Shock
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTRozanolixizumab is a humanized anti-neonatal Fc receptor (FcRn) monoclonal antibody (mAb) of the immunoglobulin G4 (IgG4) sub-class, currently in clinical development for the treatment of IgG autoantibody-driven diseases. This format is frequ
Externí odkaz:
https://doaj.org/article/f74b0a47f067425f9e3ed7abc893041a
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Background Autoimmune hepatitis (AIH) is a T-cell-mediated autoimmune liver disease that can lead to liver injury and has a poor long-term prognosis. Mesenchymal stromal cells (MSCs) have immunosuppressive effects and can treat AIH. CD4+ T c
Externí odkaz:
https://doaj.org/article/3a4a19fdb91f4c83a1f0eb2b06b70582
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Tyro3, Axl, and Mertk (abbreviated TAMs) comprise a family of homologous type 1 receptor tyrosine kinases (RTKs) that have been implicated as inhibitory receptors that dampen inflammation, but their roles in the pathogenesis of rheumatoid ar
Externí odkaz:
https://doaj.org/article/e1451aac782943b4af7c6af8f987b7a1
Autor:
Kontham Kulangara Varsha, Xiaoming Yang, Alkeiver S. Cannon, Yin Zhong, Mitzi Nagarkatti, Prakash Nagarkatti
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Macrophage activation syndrome (MAS) is a life-threatening complication of systemic juvenile arthritis, accompanied by cytokine storm and hemophagocytosis. In addition, COVID-19–related hyperinflammation shares clinical features of MAS. Mechanisms
Externí odkaz:
https://doaj.org/article/dee9da17dd404f94bc0e8504bbc06ec1
Autor:
Wen Zhu, Yang Wang, Liangyin Lv, Hui Wang, Wenqiang Shi, Zexin Liu, Mingzhe Zhou, Jianwei Zhu, Huili Lu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 5, Pp 2071-2085 (2023)
Developing universal CARs with improved flexible targeting and controllable activities is urgently needed. While several studies have suggested the potential of CD16a in tandem with monoclonal antibodies to construct universal CAR-T cells, the weak a
Externí odkaz:
https://doaj.org/article/483d45883d214370b509b2c31a785f89
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV−2) causes coronavirus disease 2019 (COVID−19). Antibodies induced by SARS-CoV−2 infection or vaccination play pivotal roles in the body’s defense against the virus; many monocl
Externí odkaz:
https://doaj.org/article/c8f4f26f466941008a03624ac128fe83
Publikováno v:
Turkish Journal of Hematology, Vol 40, Iss 1, Pp 18-27 (2023)
Objective: In minimal residual disease (MRD) analysis after allogeneic hematopoietic stem cell transplantation (allo-HSCT), abnormal immunophenotyping is commonly considered as evidence of a secondary recurrence or complications, leading to overtreat
Externí odkaz:
https://doaj.org/article/7d09725dfc71435d9a0edcad2eaf0523
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 45, Iss 1, Pp 58-65 (2023)
Introduction: Phagocytosis of autoantibody-sensitized coated platelets through Fc gamma receptors on phagocytic cells is an important mechanism of thrombocytopenia in primary immune thrombocytopenia (ITP). Objective: We aimed to investigate the contr
Externí odkaz:
https://doaj.org/article/2710057f5fb6445daea7303ea1d0fbc7
Akademický článek
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Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-11 (2022)
Abstract Background Abatacept is a recombinant fusion protein composed of the extracellular domain of cytotoxic T-lymphocyte antigen 4 and the Fc portion of immunoglobulin (Ig) G. The mechanism of action of abatacept in rheumatoid arthritis (RA) is b
Externí odkaz:
https://doaj.org/article/8e1a8d5d77314f52b647084b93b2064f