Zobrazeno 1 - 10
of 75
pro vyhledávání: '"fawaz Alzaid"'
High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus
Autor:
Marcus Z.W. Tong, Katina D. Hulme, Soi Cheng Law, Ellesandra Noye, Emily S. Dorey, Keng Yih Chew, Louise C. Rowntree, Carolien E. van de Sandt, Katherine Kedzierska, Marco Goeijenbier, Katharina Ronacher, Fawaz Alzaid, Jean-Baptiste Julla, Jean-Pierre Riveline, Katie E. Lineburg, Corey Smith, Emma J. Grant, Stephanie Gras, Linda A. Gallo, Helen L. Barrett, Kirsty R. Short
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111166- (2024)
Summary: Diabetes mellitus significantly increases the risk of severe respiratory virus disease like influenza and COVID-19. Early evidence suggests that this susceptibility to respiratory viral disease is driven by glycemic variability, rather than
Externí odkaz:
https://doaj.org/article/e64ff09be3ce403f9aed6cdf25f703ff
Autor:
Hossein Arefanian, Sardar Sindhu, Fatema Al-Rashed, Fawaz Alzaid, Ashraf Al Madhoun, Mohammed Qaddoumi, Fatemah Bahman, Michayla R. Williams, Shaima Albeloushi, Nourah Almansour, Rasheed Ahmad, Fahd Al-Mulla
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionFamilial hypercholesterolemia, the highly prevalent form of dyslipidemia, is a well-known risk factor for premature heart disease and stroke worldwide. Statins, which inhibit 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase, are
Externí odkaz:
https://doaj.org/article/87511eb9a7044e638e1a0ad8313264b5
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/3cab53515dd346e2b813c4d7751044c3
Autor:
Texy Jacob, Sardar Sindhu, Amal Hasan, Md. Zubbair Malik, Hossein Arefanian, Fatema Al-Rashed, Rasheeba Nizam, Shihab Kochumon, Reeby Thomas, Fatemah Bahman, Steve Shenouda, Ajit Wilson, Nadeem Akther, Areej Al-Roub, Nermeen Abukhalaf, Shaima Albeloushi, Mohamed Abu-Farha, Ashraf Al Madhoun, Fawaz Alzaid, Thangavel Alphonse Thanaraj, Heikki A. Koistinen, Jaakko Tuomilehto, Fahd Al-Mulla, Rasheed Ahmad
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
High-fat diets (HFDs) shape the gut microbiome and promote obesity, inflammation, and liver steatosis. Fish and soybean are part of a healthy diet; however, the impact of these fats, in the absence of sucrose, on gut microbial dysbiosis and its assoc
Externí odkaz:
https://doaj.org/article/d3ab3726b78f47ddbc7105c15171b775
Autor:
Halemah AlSaeed, Mohammed J.A. Haider, Fawaz Alzaid, Fahd Al-Mulla, Rasheed Ahmad, Fatema Al-Rashed
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110046- (2024)
Summary: The interplay between lipid metabolism and immune response in macrophages plays a pivotal role in various infectious diseases, notably tuberculosis (TB). Herein, we illuminate the modulatory effect of heat-killed Mycobacterium tuberculosis (
Externí odkaz:
https://doaj.org/article/42916db84a284e6e99ab3f7ca7c1906d
Autor:
Pauline Jacquemier, Yann Retory, Clara Virbel-Fleischman, Alexandra Schmidt, Agnes Ostertag, Martine Cohen-Solal, Fawaz Alzaid, Louis Potier, Jean-Baptiste Julla, Jean-François Gautier, Nicolas Venteclef, Jean-Pierre Riveline
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Glycemic variability remains frequent in patients with type 1 diabetes treated with insulin pumps. Heterogeneous spreads of insulin infused by pump in the subcutaneous (SC) tissue are suspected but were barely studied. We propose a new real-
Externí odkaz:
https://doaj.org/article/7b408616139147acbccfe434d886d21a
Autor:
Areej Al-Roub, Nadeem Akhter, Fatema Al-Rashed, Ajit Wilson, Fawaz Alzaid, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Studies have established the association between increased plasma levels of matrix metalloproteinase (MMP)-9 and adipose tissue inflammation. Tumor necrosis factor α (TNFα) was elevated in obesity and is involved in the induction of MMP-9
Externí odkaz:
https://doaj.org/article/cab7c9321ac24467a468e8a379a7e3d9
Autor:
Shihab Kochumon, Amnah Al-Sayyar, Texy Jacob, Hossein Arefanian, Fatemah Bahman, Nourah Almansour, Fawaz Alzaid, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 823 (2024)
CXCL10 (IP-10) plays a key role in leukocyte homing to the inflamed tissues and its increased levels are associated with the pathophysiology of various inflammatory diseases including obesity and type 2 diabetes. IL-1β is a key proinflammatory cytok
Externí odkaz:
https://doaj.org/article/6f097e036f3e4d5da351ddbde0d36cb2
Autor:
Hossein Arefanian, Ashraf Al Madhoun, Fatema Al-Rashed, Fawaz Alzaid, Fatemah Bahman, Rasheeba Nizam, Mohammed Alhusayan, Sumi John, Sindhu Jacob, Michayla R. Williams, Nermeen Abukhalaf, Steve Shenouda, Shibu Joseph, Halemah AlSaeed, Shihab Kochumon, Anwar Mohammad, Lubaina Koti, Sardar Sindhu, Mohamed Abu-Farha, Jehad Abubaker, Thangavel Alphonse Thanaraj, Rasheed Ahmad, Fahd Al-Mulla
Publikováno v:
Cells, Vol 13, Iss 11, p 949 (2024)
This study unveils verapamil’s compelling cytoprotective and proliferative effects on pancreatic β-cells amidst diabetic stressors, spotlighting its unforeseen role in augmenting cholecystokinin (CCK) expression. Through rigorous investigations em
Externí odkaz:
https://doaj.org/article/d5c54f4e6884425089959cb62cb3ac2c
Autor:
Fatema Al-Rashed, Hossein Arefanian, Ashraf Al Madhoun, Fatemah Bahman, Sardar Sindhu, Halemah AlSaeed, Texy Jacob, Reeby Thomas, Areej Al-Roub, Fawaz Alzaid, MD Zubbair Malik, Rasheeba Nizam, Thangavel Alphonse Thanaraj, Fahd Al-Mulla, Yusuf A. Hannun, Rasheed Ahmad
Publikováno v:
Cells, Vol 13, Iss 5, p 463 (2024)
Non-alcoholic fatty liver disease (NAFLD) is manifested by hepatic steatosis, insulin resistance, hepatocyte death, and systemic inflammation. Obesity induces steatosis and chronic inflammation in the liver. However, the precise mechanism underlying
Externí odkaz:
https://doaj.org/article/84981e0dc4324011a11e490c5b23e6a1