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Akademický článek

Genetic heterogeneity in familial forms of genetic generalized epilepsy: from mono- to oligogenism

Publikováno v: Human Genomics, Vol 18, Iss 1, Pp 1-18 (2024)

Abstract Genetic generalized epilepsy (GGE) including childhood absence epilepsy, juvenile absence epilepsy, juvenile myoclonic epilepsy (JME), and GGE with tonic–clonic seizures (TCS) (GGE-TCS), is genetically influenced with a two- to four- fold

Externí odkaz: https://doaj.org/article/da14490885db477eb26406082e9daf33

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Akademický článek

Specific antigen-based stratification of membranous nephropathy in patients after haematopoietic stem cell allotransplantation - a case series and literature review

Autor: Ines Bosnić Kovačić, Matija Matošević, Mario Laganović, Živka Dika, Margareta Fištrek Prlić, Ema Ivandić, Marijana Ćorić, Stela Bulimbašić, Nadira Duraković, Zinaida Perić, Lana Desnica, Radovan Vrhovac, Bojan Jelaković, Sanjeev Sethi, Ivana Vuković Brinar

Publikováno v: BMC Nephrology, Vol 25, Iss 1, Pp 1-10 (2024)

Abstract Background Nephrotic syndrome (NS) is a rare complication that can occur after haematopoietic stem cell transplantation (HSCT). In patients with membranous nephropathy (MN) who have undergone allogeneic HSCT, a new antigen called protocadher

Externí odkaz: https://doaj.org/article/93f1f8e038be4da48040a78691f73d24

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Akademický článek

FAT1 inhibits the proliferation of DLBCL cells via increasing the m6A modification of YAP1 mRNA

Autor: Tian-long Wang, Xiao-juan Miao, Yan-rong Shuai, Hao-ping Sun, Xiao Wang, Min Yang, Nan Zhang

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Abstract Emerging evidence shows that FAT atypical cadherin 1 (FAT1) mutations occur in lymphoma and are associated with poorer overall survival. Considering that diffuse large B cell lymphoma (DLBCL) is the category of lymphoma with the highest inci

Externí odkaz: https://doaj.org/article/72c3a5788cf044f098d6751f5970792a

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Akademický článek

Inhibiting autophagy enhances idarubicin chemosensitivity and induces immune escape in FAT1-low-expressing AML cells

Autor: Zhang, Nan ^a, Wang, Yu-ting ^b, Dai, Su-si ^a, Fan, Fang-yi ^a, Qiu, Ling ^a, Yi, Hai ^{a, ⁎}, Yang, Yong-jian ^{c, ⁎}

Publikováno v: In International Immunopharmacology 10 January 2025 144

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Akademický článek

Expression of FAT1 in Lung Adenocarcinoma and Its Relationship with Immune Cell Infiltration

Autor: Chen DING, Wenhao ZHAO, Hua HUANG, Yongwen LI, Zhanrui ZHANG, Ruihao ZHANG, Yanan WANG, Di WU, Chen CHEN, Hongyu LIU, Jun CHEN

Publikováno v: Chinese Journal of Lung Cancer, Vol 27, Iss 2, Pp 109-117 (2024)

Background and objective Lung cancer is a leading cause of cancer-related deaths. Non-small cell lung cancer (NSCLC) is the most common pathological subtype, with adenocarcinoma being the predominant type. FAT atypical cadherin 1 (FAT1) is a receptor

Externí odkaz: https://doaj.org/article/ea6815739b1c45748158b3ebecd48549

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Akademický článek

Pan-cancer analysis predict that FAT1 is a therapeutic target and immunotherapy biomarker for multiple cancer types including non-small cell lung cancer

Autor: Chen Ding, Hua Huang, Di Wu, Chen Chen, Yu Hua, Jinghao Liu, Yongwen Li, Hongyu Liu, Jun Chen

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

FAT1, a substantial transmembrane protein, plays a pivotal role in cellular adhesion and cell signaling. Numerous studies have documented frequent alterations in FAT1 across various cancer types, with its aberrant expression being linked to unfavorab

Externí odkaz: https://doaj.org/article/77bf9e356ff546e0904de4cbf972bec9

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Akademický článek

FAT1 upregulation is correlated with an immunosuppressive tumor microenvironment and predicts unfavorable outcome of immune checkpoint therapy in non-small cell lung cancer

Autor: Chao Chen, Yanling Li, Haozhen Liu, Mengying Liao, Jianyi Yang, Jixian Liu

Publikováno v: Heliyon, Vol 10, Iss 7, Pp e28356- (2024)

Background: Previous studies found that FAT1 was recurrently mutated and aberrantly expressed in multiple cancers, and the loss function of FAT1 promoted the formation of cancer-initiating cells in several cancers. However, in some types of cancer, F

Externí odkaz: https://doaj.org/article/07ba821dbd4a4f509e193f70354162e9

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Akademický článek

Comprehensive Genomic Profiling Identifies FAT1 as a Negative Regulator of EMT, CTCs, and Metastasis of Hepatocellular Carcinoma

Autor: Huang ZL, Zhang PB, Zhang JT, Li F, Li TT, Huang XY

Publikováno v: Journal of Hepatocellular Carcinoma, Vol Volume 10, Pp 369-382 (2023)

Zi-Li Huang,1,2,* Ping-Bao Zhang,1,3,* Jun-Tao Zhang,4 Feng Li,5 Ting-Ting Li,6 Xiu-Yan Huang1 1Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China; 2Depart

Externí odkaz: https://doaj.org/article/1826fc1f1c7b478cba5b987ed0cff088

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Akademický článek

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