Výsledky vyhledávání - "farnesyl transferase inhibitor"

Akademický článek

Use of Farnesyl Transferase Inhibitors in an Ageing Model in Drosophila

Autor: Annely Brandt, Roman Petrovsky, Maria Kriebel, Jörg Großhans

Publikováno v: Journal of Developmental Biology, Vol 11, Iss 4, p 40 (2023)

The presence of farnesylated proteins at the inner nuclear membrane (INM), such as the Lamins or Kugelkern in Drosophila, leads to specific changes in the nuclear morphology and accelerated ageing on the organismal level reminiscent of the Hutchinson

Externí odkaz: https://doaj.org/article/d8892d16d324467f93b692a5e40ec09e

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Akademický článek

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Akademický článek

Simvastatin Enhances Activity and Trafficking of α7 Nicotinic Acetylcholine Receptor in Hippocampal Neurons Through PKC and CaMKII Signaling Pathways

Autor: Tingting Chen, Ya Wang, Tingting Zhang, Baofeng Zhang, Lei Chen, Liandong Zhao, Ling Chen

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Simvastatin (SV) enhances glutamate release and synaptic plasticity in hippocampal CA1 region upon activation of α7 nicotinic acetylcholine receptor (α7nAChR). In this study, we examined the effects of SV on the functional activity of α7nAChR on C

Externí odkaz: https://doaj.org/article/adb83f9ebd29446aa1ceb507f06542b4

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Targeted therapy in juvenile myelomonocytic leukemia: Where are we now?

Autor: Nele De Vos, Mattias Hofmans, Tim Lammens, Bram De Wilde, Nadine Van Roy, Barbara De Moerloose

Publikováno v: PEDIATRIC BLOOD & CANCER

Juvenile myelomonocytic leukemia (JMML) is a rare and aggressive clonal neoplasm of early childhood, classified as an overlap myeloproliferative/myelodysplastic neoplasm by the World Health Organization. In 90% of the patients with JMML, typical init

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e4e49c767a304ac436f55afe2d63f8
https://doi.org/10.1002/pbc.29930

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Abstract P478: Farnesyl Transferase Inhibitor Tipifarnib Reduces Circulating Exosomes And Protects Against Pressure Overload-mediated Cardiac Hypertrophy

Autor: Vandana Mallaredy

Publikováno v: Circulation Research. 129

Clinically, Hypertrophic cardiomyopathy (HCM) in response to pathophysiological stress is one of the major initiating factors for the onset of cardiac remodeling leading to heart failure. Studies have revealed that HCM characterized by left ventricul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63c35576a12e07ca24cb9e6f8904310f
https://doi.org/10.1161/res.129.suppl_1.p478

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Neoadjuvant Therapy with Drug Arglabin for Breast Cancer with Expression of H-Ras Oncoproteins

Autor: Vladimir Perminov, Ainur Zhumakayeva, Kayrolla D. Rakhimov, Bakhytzhan Bekmanov, Sergazy Adekenov

Publikováno v: Asian Pacific Journal of Cancer Prevention : APJCP

Backgrounds In breast cancer, blocking of Ras signaling and inhibition of H-Ras is quite promising. H-Ras may become a target for farnesyl transferase inhibitors, and in combination with other immunohistochemical factors it will contribute to the pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2e4bd820d9a2f0901493bf06a122aa
http://europepmc.org/articles/PMC8033125

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Retracted : Prelamin A overexpression promotes detrusor calcification/aging in urinary incontinence via prelamin A accumulation

Autor: Fei Guan, Xin Gou, Zhi-Wei Yuan, Wei Luo, Jing Wu, Kewei Fang, Xin Shi, Rong‐Qiong Chen, Hai‐Xiang Guo

Publikováno v: Journal of Cellular Physiology. 234:17800-17811

Urinary incontinence (UI) is known as a distressing condition particularly among older adults, and negatively associated with health-related quality of life in both males and females. Prelamin A accumulation has been found in all progeroid laminopath

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37fd338f29291204db9f0b3b54e4b18e
https://doi.org/10.1002/jcp.28406

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Akademický článek

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K-Ras prenylation as a potential anticancer target

Autor: Balázs Hegedűs, Marcell Baranyi, László Buday

Publikováno v: Cancer Metastasis Reviews

KRAS is one of the most commonly mutated oncogene and a negative predictive factor for a number of targeted therapies. Therefore, the development of targeting strategies against mutant KRAS is urgently needed. One potential strategy involves disrupti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd7ba5f616faa9a09da3bc39546308e
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85086344710

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