Zobrazeno 1 - 10
of 27
pro vyhledávání: '"fancg gene"'
Publikováno v:
Biomedical Papers, Vol 161, Iss 2, Pp 158-163 (2017)
Background: Fanconi anemia is a rare autosomal recessive disorder of genetic instability. It is both molecularly and clinically, a heterogeneous disorder. Its incidence is 1 in 129,000 births and relatively high in some ethnic groups. Sixteen genes h
Externí odkaz:
https://doaj.org/article/a1bd360f7c17415fa5255b0f1a864892
Autor:
Chandrakala Shanmukhaiah, Revathi Raj, Sowmyashree Ramesh, Sunil Bhat, Merin George, Shailesh Kanvinde, Nita Radhakrishnan, Avani Solanki, Niranjan Chavan, Sheila Mohan, Aruna Rajendran, Deendayalan Munirathnam, Pritesh Junagade, Sandeep Nemani, Anchu Anna Cherian, Mamta Manglani, Harsha Prasada Lashkari, Radha Gulati Ghildhiyal, Sudha Rao, Babu Rao Vundinti
Publikováno v:
Human mutationREFERENCES. 42(12)
Fanconi anemia (FA) is a rare autosomal or X-linked genetic disorder characterized by chromosomal breakages, congenital abnormalities, bone marrow failure (BMF), and cancer. There has been a discovery of 22 FANC genes known to be involved in the FA p
Autor:
Nadia Elkassimi, Aziza Sbiti, Youssef El Kadiri, Siham Chafai Elalaoui, Abdelali Zrhidri, Yassamine Doubaj, Jaber Lyahyai, Maria El Kababri, Laila Hessissen, Abdelaziz Sefiani
Publikováno v:
Pan African Medical Journal; Vol. 39 No. 1 (2021)
The Pan African Medical Journal
The Pan African Medical Journal
Introduction:Fanconi anemia (FA) is a rare inherited hematological disease due to a defect in the DNA repair pathway resulting in congenital abnormalities and high susceptibility to develop cancers. The cytogenetic analysis using alkylating agents is
Publikováno v:
Biomedical Papers, Vol 161, Iss 2, Pp 158-163 (2017)
Background: Fanconi anemia is a rare autosomal recessive disorder of genetic instability. It is both molecularly and clinically, a heterogeneous disorder. Its incidence is 1 in 129,000 births and relatively high in some ethnic groups. Sixteen genes h
Autor:
David A. Dezentje, Michael J. Swartz, Michiel S. van der Heijden, Angelo M. DeMarzo, G. Johan A. Offerhaus, Jonathan R. Brody, Scott E. Kern, William H. Isacoff, Steven C. Cunningham, Eike Gallmeier, Ralph H. Hruban
Publikováno v:
Clinical cancer research, 11(20), 7508-7515. American Association for Cancer Research Inc.
Purpose: BRCA2, FANCC, and FANCG gene mutations are present in a subset of pancreatic cancer. Defects in these genes could lead to hypersensitivity to interstrand cross-linkers in vivo and a more optimal treatment of pancreatic cancer patients based
Autor:
James W. George, Allen T. Christian, Brian Souza, Nigel J. Jones, Jane Lamerdin, Larry H. Thompson, Nazumi A. Yamada
Publikováno v:
Mutagenesis. 19:237-244
The human FANCG/XRCC9 gene, which is defective in Fanconi anemia complementation group G (FA-G) cells, was first cloned by genetic complementation of the mitomycin C (MMC) sensitivity of CHO mutant UV40. The CHO NM3 mutant was subsequently assigned t
Autor:
Candice Feben, J. G. R. Kromberg, Amanda Krause, Rosalind Wainwright, Janet Poole, David K Stones, Tabitha Haw
Publikováno v:
Blood cells, moleculesdiseases. 54(3)
Fanconi anemia (FA) is a rare disorder of DNA repair, associated with various somatic abnormalities but characterized by hematological disease that manifests as bone marrow aplasia and malignancy. The mainstay of treatment, in developed nations, is h
Autor:
Naifang Lu, Alan D. D'Andrea, Tobias Hays, Yanan Kuang, Rocío Montes de Oca, Yi Yang, Lisa A. Moreau, Brian Seed
Publikováno v:
Blood. 98:3435-3440
Fanconi anemia (FA) is a human autosomal recessive cancer susceptibility disorder characterized by cellular sensitivity to mitomycin C and ionizing radiation. Six FA genes (corresponding to subtypes A, C, D2, E, F, and G) have been cloned, and the en
Autor:
Edward A. Fox, Anna Moran, Alan D. D'Andrea, Danielle Garneau, Rocío Montes de Oca, Yanan Kuang, Markus Grompe, Koji Nakanishi, Tobias Hays
Publikováno v:
Experimental Hematology. 29:842-849
Objective Fanconi anemia (FA) is an autosomal-recessive cancer susceptibility syndrome with seven complementation groups. Six of the FA genes have been cloned (corresponding to subtypes A, C, D2, E, F, and G) and the encoded proteins interact in a co
Autor:
Masao S. Sasaki, Hideo Mugishima, Takashi Shimizu, Toshiko Yamada, Mariko Okubo, Akira Tachibana
Publikováno v:
Journal of Human Genetics. 45:159-166
Fanconi anemia (FA), an autosomal recessive disorder characterized by a progressive pancytopenia associated with congenital anomalies and high predisposition to malignancies, is a genetically and clinically heterogeneous disease. At least eight compl