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How Well Does the Family Longevity Selection Score Work: A Validation Test Using the Utah Population Database

Autor: Liubov S. Arbeeva, Heidi A. Hanson, Konstantin G. Arbeev, Alexander M. Kulminski, Eric Stallard, Svetlana V. Ukraintseva, Deqing Wu, Robert M. Boudreau, Michael A. Province, Ken R. Smith, Anatoliy I. Yashin

Publikováno v: Frontiers in Public Health, Vol 6 (2018)

The Family Longevity Selection Score (FLoSS) was used to select families for the Long Life Family Study (LLFS) but has never been validated in other populations. The goal of this paper is to validate how well the FLoSS-based selection procedure works

Externí odkaz: https://doaj.org/article/0ea0ceb006e4444cbdd27d9760f45971

Familial longevity is not associated with major differences in the hypothalamic-pituitary-gonadal axis in healthy middle-aged men

Autor: Evie van der Spoel, Ferdinand Roelfsema, Steffy W. Jansen, Abimbola A. Akintola, Bart E. Ballieux, Christa M. Cobbaert, Gerard J. Blauw, P. Eline Slagboom, Rudi G.J. Westendorp, Hanno Pijl, Diana van Heemst

Publikováno v: Frontiers in Endocrinology, Vol 7 (2016)

Context: A trade-off between fertility and longevity possibly exists. The association of the male hypothalamic-pituitary-gonadal (HPG) axis with familial longevity has not yet been investigated.Objective: To study 24h hormone concentration profiles o

Externí odkaz: https://doaj.org/article/80dfeceb6ad44fa48f2a74827feb48c2

Interrelationships between pituitary hormones as assessed from 24-hour serum concentrations in healthy older subjects

Autor: Hanno Pijl, P. Eline Slagboom, Diana van Heemst, Gerard J. Blauw, Ferdinand Roelfsema, Abimbola A. Akintola, Evie van der Spoel, Rudi G. J. Westendorp, Steffy W. Jansen

Publikováno v: van der Spoel, E, Roelfsema, F, Akintola, A A, Jansen, S W, Slagboom, P E, Westendorp, R G J, Blauw, G J, Pijl, H & van Heemst, D 2020, ' Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects ', Journal of Clinical Endocrinology & Metabolism, vol. 105, no. 4, pp. e1201–e1214 . https://doi.org/10.1210/clinem/dgz253
Journal of Clinical Endocrinology and Metabolism, 105(4), 1201-1214. ENDOCRINE SOC
The Journal of Clinical Endocrinology & Metabolism
The Journal of Clinical Endocrinology and Metabolism

Context Hormones of the hypothalamic-pituitary-target gland axes are mostly investigated separately, whereas the interplay between hormones might be as important as each separate hormonal axis. Objective Our aim is to determine the interrelationships

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7641c559033e36e8e763d166c92c0d7d
https://hdl.handle.net/1887/3181201

Genome wide association and linkage analyses identified three loci -- 4q25, 17q23.2 and 10q11.21 -- associated with variation in leukocyte telomere length: The Long Life Family Study

Autor: Joseph H Lee, Rong eCheng, Lawrence S Honig, Mary eFeitosa, Candace eKammerer, Min Suk Kang, Nicole eSchupf, Jiuan eLin, Jason L Sanders, Harold T Bae, Todd eDruley, Thomas T Perls, Kaare eChristensen, Michael eProvince, Richard eMayeux

Publikováno v: Frontiers in Genetics, Vol 4 (2014)

Leukocyte telomere length is believed to measure cellular aging in humans, and short leukocyte telomere length is associated with increased risks of late onset diseases, including cardiovascular disease, dementia, etc. Many studies have shown that le

Externí odkaz: https://doaj.org/article/21690a8658c94853b7425bfa2d7b1e85