Zobrazeno 1 - 10
of 239
pro vyhledávání: '"familial Alzheimer disease"'
Autor:
Sandra Schilling, Ajay Pradhan, Amelie Heesch, Andrea Helbig, Kaj Blennow, Christian Koch, Lea Bertgen, Edward H. Koo, Gunnar Brinkmalm, Henrik Zetterberg, Stefan Kins, Simone Eggert
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-25 (2023)
Abstract The amyloid precursor protein (APP) is a key player in Alzheimer`s disease (AD) and the precursor of the Aβ peptide, which is generated by consecutive cleavages of β- and γ-secretases. Familial Alzheimer’s disease (FAD) describes a here
Externí odkaz:
https://doaj.org/article/a10b9eb7897345259b2c069974724e66
Autor:
Merel O. Mol, Sven J. van der Lee, Marc Hulsman, Yolande A. L. Pijnenburg, Phillip Scheltens, Netherlands Brain Bank, Harro Seelaar, John C. van Swieten, Laura Donker Kaat, Henne Holstege, Jeroen G. J. van Rooij
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-14 (2022)
Abstract Background Many families with clinical early-onset Alzheimer’s disease (EOAD) remain genetically unexplained. A combination of genetic factors is not standardly investigated. In addition to monogenic causes, we evaluated the possible polyg
Externí odkaz:
https://doaj.org/article/c8e6a06105dd443495870162989bb619
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1845 (2021)
Alzheimer’s disease (AD) is a complex neurodegenerative disease characterized by functional disruption, death of cholinergic neurons (ChNs) because of intracellular and extracellular Aβ aggregates, and hyperphosphorylation of protein TAU (p-TAU).
Externí odkaz:
https://doaj.org/article/d6f197876d61427f8923e40928cec981
Akademický článek
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Autor:
Jazmín X. Suárez-Revelo, John F. Ochoa-Gómez, Jon E. Duque-Grajales, Carlos A. Tobón-Quintero
Publikováno v:
Ingeniería e Investigación, Vol 36, Iss 3, Pp 50-57 (2016)
Alzheimer’s disease (AD) is the most common cause of dementia, which generally affects people over 65 years old. Some genetic mutations induce early onset of AD and help to track the evolution of the symptoms and the physiological changes at differ
Externí odkaz:
https://doaj.org/article/1ad31235f06f4208bc3dad9cb85ae56b
Publikováno v:
Journal of Alzheimer's Disease
Background: Alzheimer’s disease (AD) is characterized by structural damage, death, and functional disruption of cholinergic neurons (ChNs) as a result of intracellular amyloid-β (Aβ) aggregation, extracellular neuritic plaques, and hyperphosphory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1c1f58beb1c6368dcaf6a974d35b7c
https://doi.org/10.3233/jad-201045
https://doi.org/10.3233/jad-201045
Autor:
Mol, Merel O., van der Lee, S.J., Hulsman, M., Pijnenburg, Yolande A.L., Scheltens, Phillip, Seelaar, Harro, van Swieten, John C., Kaat, Laura Donker, Holstege, H., van Rooij, Jeroen G.J.
Publikováno v:
Alzheimer's Research and Therapy, 14(1):77. BioMed Central Ltd.
Alzheimer's Research and Therapy, 14(1)
Alzheimer's Research and Therapy, 14(1)
Background: Many families with clinical early-onset Alzheimer’s disease (EOAD) remain genetically unexplained. A combination of genetic factors is not standardly investigated. In addition to monogenic causes, we evaluated the possible polygenic arc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::56388094d13c5e6eb82770527c0a7f9c
https://pure.eur.nl/en/publications/32ec8e4c-9ca5-43f1-8083-d11d0ea9c98e
https://pure.eur.nl/en/publications/32ec8e4c-9ca5-43f1-8083-d11d0ea9c98e
Background: Many families with clinical early-onset Alzheimer’s disease (EOAD) remain genetically unexplained. A combination of genetic factors is not standardly investigated. In addition to monogenic causes, we evaluated the possible polygenic arc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___00893::fb084bd2711e247fae836a3470d9b6dc
https://doi.org/10.1186/s13195-022-01018-3
https://doi.org/10.1186/s13195-022-01018-3
Autor:
Ugo Paolo Guerra, Innocenzo Rainero, Natale Quartuccio, Daniele Imperiale, Angelina Cistaro, Laura Cassalia, Cristiana Atzori, D. Vai
Positron emission tomography (PET) with 18 F-Fluorodeoxyglucose ( 18 F-FDG) plays an outstanding role in the diagnostic work-up of dementia. Amyloid PET imaging is a complementary imaging technique for the early detection of Alzheimer disease (AD).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::debabc89298efce6f2b6ec1f5bb642b1
https://hdl.handle.net/2318/1894586
https://hdl.handle.net/2318/1894586
Autor:
Miranda L. Bader Lange, Daret St. Clair, William R. Markesbery, Christa M. Studzinski, M. Paul Murphy, D. Allan Butterfield
Publikováno v:
Neurobiology of Disease, Vol 38, Iss 1, Pp 104-115 (2010)
Using APPNLh/APPNLh x PS-1P246L/PS-1P246L human double knock-in (APP/PS-1) mice, we examined whether phosphatidylserine (PtdSer) asymmetry is significantly altered in brain of this familial Alzheimer disease mouse model in an age-dependent manner as
Externí odkaz:
https://doaj.org/article/98b19aae5a2c40e69b84eb51b22f708a