Výsledky vyhledávání - "extracellular signal-regulated kinase signaling pathway"

Akademický článek

Knockdown of neurotrophin receptor-interacting melanoma-associated antigen homolog inhibits acute myeloid leukemia cell growth via the ERK pathway

Autor: Hongxia Zhang, Guangsheng Wu, Beili Chen

Publikováno v: Chinese Journal of Physiology, Vol 66, Iss 4, Pp 276-283 (2023)

Neurotrophin receptor-interacting melanoma-associated antigen homolog (NRAGE), a type II melanoma-associated antigen, plays a critical role in cell processes that are involved in the tumorigenesis of various cancers. However, the effect of NRAGE on a

Externí odkaz: https://doaj.org/article/c30338d9327349da9a85eae95cc8e491

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Akademický článek

Identification of key genes involved in axon regeneration and Wallerian degeneration by weighted gene co-expression network analysis

Autor: Yan Lu, Qi Shan, Mei Ling, Xi-An Ni, Su-Su Mao, Bin Yu, Qian-Qian Cao

Publikováno v: Neural Regeneration Research, Vol 17, Iss 4, Pp 911-919 (2022)

Peripheral nerve injury repair requires a certain degree of cooperation between axon regeneration and Wallerian degeneration. Therefore, investigating how axon regeneration and degeneration work together to repair peripheral nerve injury may uncover

Externí odkaz: https://doaj.org/article/fb1f3f4d9cd04419901a1b40c9cce6f8

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Akademický článek

Mucin 4 Gene Silencing Reduces Oxidative Stress and Calcium Oxalate Crystal Formation in Renal Tubular Epithelial Cells Through the Extracellular Signal-Regulated Kinase Signaling Pathway in Nephrolithiasis Rat Model

Autor: Ling Sun, Lu-Xi Zou, Jie Wang, Ting Chen, Yu-Chen Han, Dong-Dong Zhu, Shi-Chao Zhuo

Publikováno v: Kidney & Blood Pressure Research, Vol 43, Iss 3, Pp 820-835 (2018)

Background/Aims: Nephrolithiasis plagues a great number of patients all over the world. Increasing evidence shows that the extracellular signal-regulated kinase (ERK) signaling pathway and renal tubular epithelial cell (RTEC) dysfunction and attritio

Externí odkaz: https://doaj.org/article/6b57061f39684bfc97df369b601534ee

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Akademický článek

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Akademický článek

Pterygium epithelium abnormal differentiation related to activation of extracellular signal-regulated kinase signaling pathway in vitro

Autor: Juan Peng, Xiang-Yin Sha, Yi Liu, Rui-Ming Yang, Ye Wen

Publikováno v: International Journal of Ophthalmology, Vol 8, Iss 6, Pp 1118-1125 (2015)

AIM: To investigate whether the abnormal differentiation of the pterygium epithelium is related to the extracellular signal-regulated kinase (ERK) signaling pathway in vitro. METHODS: The expression levels of phosphorylated ERK (P-ERK), keratin fami

Externí odkaz: https://doaj.org/article/08fc15d8f49543308935a8e52f048ffb

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Akademický článek

Small Interfering RNA Specific for N-Methyl-D-Aspartate Receptor 2B Offers Neuroprotection to Dopamine Neurons through Activation of MAP Kinase

Autor: Olivia T.W. Ng, L.W. Chen, Y.S. Chan, Ken K.L. Yung

Publikováno v: Neurosignals, Vol 21, Iss 1-2, Pp 42-54 (2012)

In the present study, N-methyl-D-aspartate receptor 2B (NR2B)-specific siRNA was applied in parkinsonian models. Our previous results showed that reduction in expression of N-methyl-D-aspartate receptor 1 (NR1), the key subunit of N-methyl-D-aspartat

Externí odkaz: https://doaj.org/article/d98b0756d6c7499c91b9eec552ec99a5

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miR‑302d‑3p regulates the viability, migration and apoptosis of breast cancer cells through regulating the TMBIM6‑mediated ERK signaling pathway

Autor: Ling Bai, Yanru Liao, Zhenxiong Qiu

Publikováno v: Molecular Medicine Reports

MicroRNAs (miRs/miRNAs) play important roles in the occurrence, metastasis and prognosis of multiple types of cancers. However, the specific role of miR‑302d‑3p and its underlying mechanism in breast cancer (BC) have not yet been reported. The pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a615e43455484e49bdd64407281426
https://doi.org/10.3892/mmr.2021.12493

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MicroRNA-98 suppresses cell growth and invasion of retinoblastoma via targeting the IGF1R/k-Ras/Raf/MEK/ERK signaling pathway

Autor: Hong Ma, Yu Bai, Shuzhe Ji, Long Guo

Publikováno v: International Journal of Oncology

Accumulating evidence has indicated that the dysregulation of microRNAs (miRNAs) is involved in the pathogenesis o retinoblastoma (RB); however, the potential role of miR‑98 in RB remains elusive. In the present study, it was demonstrated that miR�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36282053635b4b958c04a9a7d60d2c98
http://europepmc.org/articles/PMC6365030

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