Zobrazeno 1 - 10
of 827
pro vyhledávání: '"extracellular matrix remodeling"'
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Background Hepatocellular carcinoma (HCC) arising from metabolic dysfunction-associated steatohepatitis (MASH) presents a significant clinical challenge, particularly given the prevalence of the Western diet (WD). The influence of diet on th
Externí odkaz:
https://doaj.org/article/1bbfb756ac744be9b538f4c0418e5dc9
Autor:
Hong Wang, Huizi Sun, Jie Huang, Zhenhua Zhang, Guodi Cai, Chaofan Wang, Kai Xiao, Xiaofeng Xiong, Jian Zhang, Peiqing Liu, Xiaoyun Lu, Weineng Feng, Junjian Wang
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2043-2059 (2024)
Abstract Small-cell lung cancer (SCLC) is the most aggressive and lethal type of lung cancer, characterized by limited treatment options, early and frequent metastasis. However, the determinants of metastasis in SCLC are poorly defined. Here, we show
Externí odkaz:
https://doaj.org/article/73f205a84a4949039ad407236f64b767
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Extracellular matrix (ECM) remodeling in skeletal muscle is a significant factor in the development of sarcopenia. This study aims to evaluate changes in ECM remodeling in the lumbar paravertebral muscles of sarcopenic rats using
Externí odkaz:
https://doaj.org/article/ea718837d89a4f94a98cd027399175b2
Autor:
Chao Xu, Kun Yang, Yin Xu, Xiangfu Meng, Ying Zhou, Yanping Xu, Xueyao Li, Weihua Qiao, Jiawei Shi, Donghui Zhang, Jianglin Wang, Weilin Xu, Hongjun Yang, Zhiqiang Luo, Nianguo Dong
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Tissue engineered heart valves (TEHVs) demonstrates the potential for tissue growth and remodel, offering particular benefit for pediatric patients. A significant challenge in designing functional TEHV lies in replicating the anisotropic mec
Externí odkaz:
https://doaj.org/article/b3bbff980f904f3d817ee735a2a3403d
Publikováno v:
Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss 6, Pp 1080-1083 (2024)
Matrix metalloproteinase-1 (MMP-1) plays a pivotal role in the pathogenesis of periodontal diseases, particularly periodontitis, by virtue of its collagenolytic activity targeting collagen type I, the primary component of periodontal tissues. This re
Externí odkaz:
https://doaj.org/article/579fbea85ee04709a02effe165aa3801
Autor:
Qinghu Yang, Chengxiang Yan, Yahan Sun, Zhen Xie, Liang Yang, Ming Jiang, Junjun Ni, Beining Chen, Sen Xu, Zhaoyue Yuan, Yanyan Wu, Xia Liu, Zengqiang Yuan, Zhantao Bai
Publikováno v:
Advanced Science, Vol 11, Iss 31, Pp n/a-n/a (2024)
Abstract Extracellular matrix (ECM) remodeling is strongly linked to Alzheimer's disease (AD) risk; however, the underlying mechanisms are not fully understood. Here, it is found that the injection of chondroitinase ABC (ChABC), mimicking ECM remodel
Externí odkaz:
https://doaj.org/article/bcfa97501e494d9699f74a4679329739
Publikováno v:
Biology Direct, Vol 18, Iss 1, Pp 1-19 (2023)
Abstract Background Bicuspid aortic valve (BAV) is the most prevalent congenital valvular heart defect, and around 50% of severe isolated calcific aortic valve disease (CAVD) cases are associated with BAV. Although previous studies have demonstrated
Externí odkaz:
https://doaj.org/article/983042f5ac5c46daa480bd6d186568a8
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1257 (2024)
Chronic inflammatory lung diseases are characterized by disease-specific extracellular matrix accumulation resulting from an imbalance of matrix metalloproteinases (MMPs) and their inhibitors. Zinc is essential for the function of MMPs, and zinc defi
Externí odkaz:
https://doaj.org/article/54c34c97cc3242b28e9e71be9a6ef7ac
Publikováno v:
eLife, Vol 12 (2023)
Background: To systematically identify cell types in the human ligament, investigate how ligamental cell identities, functions, and interactions participated in the process of ligamental degeneration, and explore the changes of ligamental microenviro
Externí odkaz:
https://doaj.org/article/35a419c25d314a5f98a7825f52555ae5
Autor:
Leandro do Nascimento Camargo, Renato Fraga Righetti, Francine Maria de Almeida, Tabata Maruyama dos Santos, Silvia Fukuzaki, Nilo Arthur Bezerra Martins, Miguel Cantadori Barbeiro, Beatriz Mangueira Saraiva-Romanholo, Fernanda Degobbi Tenorio Quirino dos Santos Lopes, Edna Aparecida Leick, Carla Máximo Prado, Iolanda de Fátima Lopes Calvo Tibério
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundIL-17 is a modulator of the inflammatory response and is implicated in lung remodeling in both asthma and chronic obstructive pulmonary disease (COPD). Well as and probably in patients with asthma–COPD overlap (ACO).MethodsIn this study,
Externí odkaz:
https://doaj.org/article/017731df7b6946a1a43bde2d4f7984e8