Zobrazeno 1 - 10
of 4 686
pro vyhledávání: '"extracellular domain"'
Osteocalcin binds to a GPRC6A Venus fly trap allosteric site to positively modulate GPRC6A signaling
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 9, Pp 365-376 (2024)
Abstract GPRC6A, a member of the Family C G‐protein coupled receptors, regulates energy metabolism and sex hormone production and is activated by diverse ligands, including cations, L‐amino acids, the osteocalcin (Ocn) peptide and the steroid hor
Externí odkaz:
https://doaj.org/article/6595614307174a96a72a2183c31401dd
Autor:
Yinjie Liang, Junjia Guo, Zhen Li, Shiyuan Liu, Ting Zhang, Shucai Sun, Funa Lu, Yuqian Zhai, Wenling Wang, Chuanyi Ning, Wenjie Tan
Publikováno v:
Biosafety and Health, Vol 6, Iss 3, Pp 178-185 (2024)
The matrix protein 2 (M2) is a preferred target for developing a universal vaccine against the influenza A virus (IAV). This study aimed to develop a method for assessing antibody-dependent cell-mediated cytotoxicity (ADCC) associated with M2-based i
Externí odkaz:
https://doaj.org/article/11ff126d9fd04d37aeafc2ce2f986a51
Autor:
Pan Tang, Enhui Cui, Jinghua Cheng, Benqiang Li, Jie Tao, Ying Shi, Jiajie Jiao, Enqi Du, Jingyu Wang, Huili Liu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionSwine influenza viruses (SIVs) pose significant economic losses to the pig industry and are a burden on global public health systems. The increasing complexity of the distribution and evolution of different serotypes of influenza strains
Externí odkaz:
https://doaj.org/article/9b1052ccf031482f9465d4b22111fa5d
Autor:
Chihiro Namatame, Yoichiro Abe, Yoshiki Miyasaka, Yoshiki Takai, Yuki Matsumoto, Toshiyuki Takahashi, Tomoji Mashimo, Tatsuro Misu, Kazuo Fujihara, Masato Yasui, Masashi Aoki
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8169 (2024)
Conventional rodent neuromyelitis optica spectrum disorder (NMOSD) models using patient-derived immunoglobulin G (IgG) are potentially affected by the differences between the human and rodent aquaporin-4 (AQP4) extracellular domains (ECDs). We hypoth
Externí odkaz:
https://doaj.org/article/c5b569515a6744dba00b577ec6478122
Autor:
Yohei Harada, Akemi Sato, Hideaki Nakamura, Keita Kai, Sho Kitamura, Tomomi Nakamura, Yuki Kurihara, Sadakatsu Ikeda, Eisaburo Sueoka, Shinya Kimura, Naoko Sueoka-Aragane
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background Precision medicine with gene panel testing based on next-generation sequencing for patients with cancer is being used increasingly in clinical practice. HER2, which encodes the human epidermal growth factor receptor 2 (HER2), is a
Externí odkaz:
https://doaj.org/article/58da1db4a59749cd927caec6d97af0d0
Autor:
Kong Huifang, Zhao Shangqi, Zheng Jia, Liu Bin, Zhou Yanxia, Li Yanmin, Zhou Wentao, Zhou Xiaotao
Publikováno v:
Open Life Sciences, Vol 17, Iss 1, Pp 1555-1567 (2022)
Externí odkaz:
https://doaj.org/article/c6bd754189374a47873b3a75321565eb
Autor:
W.H. Guo, Y.J. Zhu, G. Haimiti, X.R. Xie, C. Niu, M. Li, J. Shi, Z.W. Yin, M.K. Yu, J.B. Ding, F.B. Zhang
Publikováno v:
Brazilian Journal of Medical and Biological Research, Vol 56 (2023)
Brucellosis has become a global zoonotic disease, seriously endangering the health of people all over the world. Vaccination is an effective strategy for protection against Brucella infection in livestock in developed countries. However, current vacc
Externí odkaz:
https://doaj.org/article/1aabcd5d64954e94b9fe56df2cfe4c4d
Autor:
Lina El Badaoui, Alastair J. Barr
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 820 (2024)
The receptor-type protein tyrosine phosphatases (RPTPs) are involved in a wide variety of physiological functions which are mediated via their diverse extracellular regions. They play key roles in cell–cell contacts, bind various ligands and are re
Externí odkaz:
https://doaj.org/article/095df85130b94946b7264e88c003abaf
Progress to Clarify How NOTCH3 Mutations Lead to CADASIL, a Hereditary Cerebral Small Vessel Disease
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 127 (2024)
Notch signaling is conserved in C. elegans, Drosophila, and mammals. Among the four NOTCH genes in humans, NOTCH1, NOTCH2, and NOTCH3 are known to cause monogenic hereditary disorders. Most NOTCH-related disorders are congenital and caused by a gain
Externí odkaz:
https://doaj.org/article/61373c558c2c48a4ad9bdc0e5279f166
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