Zobrazeno 1 - 10
of 221
pro vyhledávání: '"extracellular acidosis"'
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Tubulointerstitial kidney disease associated microenvironmental dysregulation, like acidification, inflammation and fibrosis, affects tubule cells and fibroblasts. Micromilieu homeostasis influences intracellular signaling and int
Externí odkaz:
https://doaj.org/article/4cb8fe8b1a674039a9beef8f7bf9123b
Autor:
Tiago M. A. Carvalho, Madelaine Magalì Audero, Maria Raffaella Greco, Marilena Ardone, Teresa Maggi, Rosanna Mallamaci, Barbara Rolando, Silvia Arpicco, Federico Alessandro Ruffinatti, Alessandra Fiorio Pla, Natalia Prevarskaya, Tomas Koltai, Stephan J. Reshkin, Rosa Angela Cardone
Publikováno v:
Cells, Vol 13, Iss 9, p 730 (2024)
Background: Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with high mortality due to early metastatic dissemination and high chemoresistance. All these factors are favored by its extracellular matrix (ECM)-rich microenvironment, which i
Externí odkaz:
https://doaj.org/article/359ae37a40954942bc5f86182bbda81f
Autor:
Yong-Jin Kwon, Eun-Bi Seo, Ae Jin Jeong, Song-Hee Lee, Kum Hee Noh, Sangsik Lee, Chung-Hyun Cho, Chang-Han Lee, Hyun Mu Shin, Hang-Rae Kim, Hyeong-Gon Moon, Sang-Kyu Ye
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Tumor acidosis, a common phenomenon in solid cancers such as breast cancer, is caused by the abnormal metabolism of cancer cells. The low pH affects cells surrounding the cancer, and tumor acidosis has been shown to inhibit the activity of i
Externí odkaz:
https://doaj.org/article/3c76d7a6e1f3484c9326417ca63283f0
Akademický článek
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Autor:
Elena Andreucci, Bianca Saveria Fioretto, Irene Rosa, Marco Matucci-Cerinic, Alessio Biagioni, Eloisa Romano, Lido Calorini, Mirko Manetti
Publikováno v:
Cells, Vol 12, Iss 6, p 939 (2023)
Lactic acidosis characterizes the tumor microenvironment (TME) and is involved in the mechanisms leading to cancer progression and dissemination through the reprogramming of tumor and local host cells (e.g., endothelial cells, fibroblasts, and immune
Externí odkaz:
https://doaj.org/article/e71f72ec2bcf4a4594f63242c6921cfa
Autor:
A. Varese, E. Dantas, A. Paletta, W. Fitzgerald, F. Di Diego García, G. Cabrerizo, F. Erra Diaz, L. A. Defelipe, H. Pallares, M. Dodes Traian, A. Gamarnik, J. Geffner, F. Remes Lenicov, L. Margolis, A. Ceballos
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 1169-1179 (2021)
Zika virus (ZIKV) is a flavivirus transmitted by mosquitoes of the genus Aedes, but unlike other flaviviruses, ZIKV can be sexually transmitted by vaginal intercourse. The healthy vaginal pH ranges from 4.0 to 6.0, reaching values of 6.0–7.0 after
Externí odkaz:
https://doaj.org/article/3b57af8d574c4b5cafcc5d56155f729d
Autor:
Marie-Christin Schulz, Virginie Dubourg, Alexander Nolze, Michael Kopf, Gerald Schwerdt, Michael Gekle
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 412 (2023)
Crosstalk of renal epithelial cells with interstitial fibroblasts plays an important role in kidney pathophysiology. A previous study showed that crosstalk between renal epithelial cells and renal fibroblasts protects against acidosis-induced damage.
Externí odkaz:
https://doaj.org/article/4404032215334d618415a9bd78a7e602
Akademický článek
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Akademický článek
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Publikováno v:
Biomedicines, Vol 10, Iss 3, p 681 (2022)
Pathogenesis of chronic kidney disease (CKD) is accompanied by extracellular acidosis inflammation, fibrosis and epithelial-to-mesenchymal transition (EMT). The aim of this study was to assess the influence of acidosis on tubule epithelial cells (NRK
Externí odkaz:
https://doaj.org/article/4c54cee209ec4cb790561ee17315f9c9