Zobrazeno 1 - 10
of 4 957
pro vyhledávání: '"expression quantitative trait loci"'
Publikováno v:
Journal of Engineering and Applied Science, Vol 71, Iss 1, Pp 1-15 (2024)
Abstract Transcriptome-wide association studies (TWAS) goal is to better understand the etiology of diseases and develop preventative and therapeutic approaches by examining the connections between genetic variants and phenotypes while overcoming the
Externí odkaz:
https://doaj.org/article/e8d9789c4cae4d7c907201ece6080d29
Autor:
Rongrong Zhong, Yifen Guo, Jianxing Huang, Yingao Yang, Shuyue Ren, Yan Gu, Ping Lei, Zhixian Gao
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
BackgroundPreeclampsia (PE) is a global pregnancy concern, characterized by hypertension with an unclear etiology. This study employs Mendelian randomization (MR) and single-cell RNA sequencing (scRNA-seq) to clarify its genetic and molecular roots,
Externí odkaz:
https://doaj.org/article/40aa13dcd4cb4888b5bfd69e4b9bf5ab
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
BackgroundThis study aims to prioritize genes potentially involved in multifactorial or causal relationships with gout.MethodsUsing the Summary Data-based Mendelian Randomization (SMR) approach, this research analyzed expression quantitative trait lo
Externí odkaz:
https://doaj.org/article/c1d5c131468f4580b9decde2108f9a8a
Autor:
Seung Hyuk T. Lee, Kristina M. Garske, Uma Thanigai Arasu, Asha Kar, Zong Miao, Marcus Alvarez, Amogha Koka, Nicholas Darci-Maher, Jihane N. Benhammou, David Z. Pan, Tiit Örd, Dorota Kaminska, Ville Männistö, Sini Heinonen, Martin Wabitsch, Markku Laakso, Vatche G. Agopian, Joseph R. Pisegna, Kirsi H. Pietiläinen, Jussi Pihlajamäki, Minna U. Kaikkonen, Päivi Pajukanta
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105232- (2024)
Summary: Background: Abdominal obesity increases the risk for non-alcoholic fatty liver disease (NAFLD), now known as metabolic dysfunction-associated steatotic liver disease (MASLD). Methods: To elucidate the directional cell-type level biological m
Externí odkaz:
https://doaj.org/article/a9ca2e74a8164304bf81b6dd03723f19
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundAtrial fibrillation (AF) is a common persistent arrhythmia characterized by rapid and chaotic atrial electrical activity, potentially leading to severe complications such as thromboembolism, heart failure, and stroke, significantly affectin
Externí odkaz:
https://doaj.org/article/dfda748693df446bb421525e53781ac3
Autor:
Jiancheng Huang, Mingkuan Su, Fanhui Kong, Hongbin Chen, Shuiqing Wu, Jianfeng Guo, Haiying Wu
Publikováno v:
Liver Research, Vol 8, Iss 1, Pp 54-60 (2024)
Background and aim: A genome-wide association study has indicated the association of numerous genes in the 6p21.3 region with chronic hepatitis B virus (HBV) infection. In this study, we screened 12 representative single-nucleotide polymorphisms (SNP
Externí odkaz:
https://doaj.org/article/e92a52a76e124bb4a52554c7fb7f58b0
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background The term eGene has been applied to define a gene whose expression level is affected by at least one independent expression quantitative trait locus (eQTL). It is both theoretically and empirically important to identify eQTLs and e
Externí odkaz:
https://doaj.org/article/6f4d1df2c8284b698785fc64f7921d51
Autor:
Felipe André Oliveira Freitas, Luiz F. Brito, Simara Larissa Fanalli, Janaína Lustosa Gonçales, Bruna Pereira Martins da Silva, Mariah Castro Durval, Fernanda Nery Ciconello, Camila Sabino de Oliveira, Lucas Echevarria Nascimento, Izally Carvalho Gervásio, Julia Dezen Gomes, Gabriel Costa Monteiro Moreira, Bárbara Silva-Vignato, Luiz Lehmann Coutinho, Vivian Vezzoni de Almeida, Aline Silva Mello Cesar
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background Mapping expression quantitative trait loci (eQTLs) in skeletal muscle tissue in pigs is crucial for understanding the relationship between genetic variation and phenotypic expression of carcass traits in meat animals. Therefore, t
Externí odkaz:
https://doaj.org/article/66923c9308f74f4ea2e997209e25d848
Autor:
Sainan Zhang, Ping Wang, Lei Shi, Chao Wang, Zijun Zhu, Changlu Qi, Yubin Xie, Shuofeng Yuan, Liang Cheng, Xin Yin, Xue Zhang
Publikováno v:
Virus Research, Vol 342, Iss , Pp 199341- (2024)
Genome-wide association study (GWAS) analysis has exposed that genetic factors play important roles in COVID-19. Whereas a deeper understanding of the underlying mechanism of COVID-19 was hindered by the lack of expression of quantitative trait loci
Externí odkaz:
https://doaj.org/article/2adeba3346da4c3b9a4c2a8567c81e48
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
IntroductionPeripheral vascular atherosclerosis (PVA) is a chronic inflammatory disease characterized by lipid accumulation in blood vessel walls, leading to vessel narrowing and inadequate blood supply. However, the molecular mechanisms underlying P
Externí odkaz:
https://doaj.org/article/d27411701b984894ac4e1863487565b6