Zobrazeno 1 - 10
of 396
pro vyhledávání: '"expression control"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101280- (2024)
Adeno-associated virus (AAV) vectors have become the leading platform for gene delivery in both preclinical research and therapeutic applications, making the production of high-titer AAV preparations essential. To date, most AAV-based studies use con
Externí odkaz:
https://doaj.org/article/f2f2f5ab3b8049c899dee3e3ac4bce71
Autor:
Zrinka Raguz Nakic, Christin Peters
Publikováno v:
CHIMIA, Vol 77, Iss 6 (2023)
Preparation of expression vectors using conventional cloning strategies is laborious and not suitable for the design of metabolic pathways or enzyme cascades, which usually requires the preparation of a vector library to identify productive clones. R
Externí odkaz:
https://doaj.org/article/e18c6a370b7b476ebdb28fa02924a28c
Akademický článek
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Autor:
Alex Ranieri Jerônimo Lima, Herbert Guimarães de Sousa Silva, Saloe Poubel, Juliana Nunes Rosón, Loyze Paola Oliveira de Lima, Héllida Marina Costa-Silva, Camila Silva Gonçalves, Pedro A. F. Galante, Fabiola Holetz, Maria Cristina Machado M. Motta, Ariel M. Silber, M. Carolina Elias, Julia Pinheiro Chagas da Cunha
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-16 (2022)
Abstract Background Genomic organization and gene expression regulation in trypanosomes are remarkable because protein-coding genes are organized into codirectional gene clusters with unrelated functions. Moreover, there is no dedicated promoter for
Externí odkaz:
https://doaj.org/article/9a574499a4724a0987c9f2e9697fd782
Autor:
Rajamanickam Murugan, Gabriel Kreiman
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 5115-5135 (2022)
Response time decides how fast a gene can react against an external signal at the transcription level in a signalling cascade. The steady state protein levels of the responding genes decide the coupling between two consecutive members of a signalling
Externí odkaz:
https://doaj.org/article/ccd2245d64f3426191e24ca997ee94d5
Akademický článek
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Publikováno v:
eLife, Vol 11 (2022)
CRISPR technology has made generation of gene knock-outs widely achievable in cells. However, once inactivated, their re-activation remains difficult, especially in diploid cells. Here, we present DExCon (Doxycycline-mediated endogenous gene Expressi
Externí odkaz:
https://doaj.org/article/0e55ab7449604c44903c7cabfb81df3a
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102170- (2021)
The role of heme oxygenase-1 in resisting oxidative stress and cell protection has always been a hot research topic. With the continuous deepening of research, in addition to directly regulating redox by catalyzing the degradation of heme, HO-1 prote
Externí odkaz:
https://doaj.org/article/6485b4927bb349dab57b2346d5179690
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Dynamic control of gene expression mainly relies on inducible systems, which require supplementation of (costly) inducer molecules. In contrast, synthetic regulatory circuits, which allow the timed shutdown of gene expression, are rarely available an
Externí odkaz:
https://doaj.org/article/f7a01f099f23481ba94ce2bd63283a4d
Autor:
Dumitru Andrei Iacobas, Lei Xi
Publikováno v:
Journal of Personalized Medicine, Vol 12, Iss 8, p 1246 (2022)
The genomic fabric paradigm (GFP) characterizes the transcriptome topology by the transcripts’ abundances, the variability of the expression profile, and the inter-coordination of gene expressions in each pathophysiological condition. The expressio
Externí odkaz:
https://doaj.org/article/06bd8aae6d354354882ec096bcc6f5e5