The influence of sex, genotype, and dose on serum and hippocampal cytokine levels in juvenile mice developmentally exposed to a human-relevant mixture of polychlorinated biphenyls

Autor: Lauren Matelski, Kimberly P. Keil Stietz, Sunjay Sethi, Sandra L. Taylor, Judy Van de Water, Pamela J. Lein

Publikováno v: Current Research in Toxicology, Vol 1, Iss , Pp 85-103 (2020)

Polychlorinated biphenyls (PCBs) are pervasive environmental contaminants implicated as risk factors for neurodevelopmental disorders (NDDs). Immune dysregulation is another NDD risk factor, and developmental PCB exposures are associated with early l

Externí odkaz: https://doaj.org/article/ab9b39b69def40d6987d2d6d765c70cd

Glial Cell Dysfunction in C9orf72-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Autor: Mehdi Ghasemi, Kiandokht Keyhanian, Catherine Douthwright

Publikováno v: Cells, Vol 10, Iss 2, p 249 (2021)

Since the discovery of the chromosome 9 open reading frame 72 (C9orf72) repeat expansion mutation in 2011 as the most common genetic abnormality in amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease) and frontotemporal dementia

Externí odkaz: https://doaj.org/article/8a002479f86d4af393ef6712ef3e0c32

Glial Cell Dysfunction in C9orf72-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Autor: Kiandokht Keyhanian, Mehdi Ghasemi, Catherine Douthwright

Publikováno v: Cells, Vol 10, Iss 249, p 249 (2021)
Cells

Since the discovery of the chromosome 9 open reading frame 72 (C9orf72) repeat expansion mutation in 2011 as the most common genetic abnormality in amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease) and frontotemporal dementia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bab7d90f46be7051f12a9d9dd6255c1
https://www.mdpi.com/2073-4409/10/2/249

A proteomic network approach across the ALS‐FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain

Autor: Allan I. Levey, Jingting Dai, Nicholas T. Seyfried, Jonathan D. Glass, Duc M. Duong, Mfon E. Umoh, Eric B. Dammer, Marla Gearing, James J. Lah

Publikováno v: EMBO Molecular Medicine, Vol 10, Iss 1, Pp 48-62 (2018)
EMBO Molecular Medicine

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases with overlap in clinical presentation, neuropathology, and genetic underpinnings. The molecular basis for the overlap of these disorders is not well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56016e698f0fdb6854cbec0790912470
https://doaj.org/article/b8b7499dd4d9446c941b6c08b5f8bee4

Exploring transcriptional single-cell signatures in a mouse model of epilepsy caused by a polyalanine expansion mutation in Aristaless-related homeobox gene

Autor: Tuccillo M, Mangano E, Verrillo L, Poeta L, Consolandi C, Padula A, Franco C, Drongitis D, Mallardo M, Cervicato G, Canzoniero L M T, Bordoni R, Miano MG.

Publikováno v: EMBO Workshop-From epigenome towards epitranscriptome in cell fate choice, Capri, Nplaes, Italy, 14-17 October 2018
info:cnr-pdr/source/autori:Tuccillo M, Mangano E, Verrillo L, Poeta L, Consolandi C, Padula A, Franco C, Drongitis D, Mallardo M, Cervicato G, Canzoniero L M T, Bordoni R, Miano MG./congresso_nome:EMBO Workshop-From epigenome towards epitranscriptome in cell fate choice/congresso_luogo:Capri, Nplaes, Italy/congresso_data:14-17 October 2018/anno:2018/pagina_da:/pagina_a:/intervallo_pagine

The X-linked Aristaless-related homeobox gene (ARX) encodes an interneuron-specific transcription factor (TF) with a key role in mammalian corticogenesis and GABAergic sub-type specification. Elongations in two of its four polyalanine (PolyA) tracts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::c08c714cc21955e487e3dbf4bb7a21cf
http://www.cnr.it/prodotto/i/434897