Extracellular vesicles: fundamentals and clinical relevance

Autor: Wael Nassar, Mervat El-Ansary, Mostafa Abdel Aziz, Ehab El-Hakim

Publikováno v: The Egyptian Journal of Internal Medicine, Vol 27, Iss 1, Pp 1-7 (2015)

All types of cells of eukaryotic organisms produce and release small nanovesicles into their extracellular environment. Early studies have described these vesicles as ′garbage bags′ only to remove obsolete cellular molecules. Valadi and colleague

Externí odkaz: https://doaj.org/article/3ce7b8fce0ac4f9f838052267d2e0b8c

Zebrafish Melanoma-Derived Interstitial EVs Are Carriers of ncRNAs That Induce Inflammation

Autor: Valentina Biagini, Federica Busi, Viviana Anelli, Emanuela Kerschbamer, Marta Baghini, Elena Gurrieri, Michela Notarangelo, Isabella Pesce, Guillaume van Niel, Vito G. D’Agostino, Marina Mione

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2022, 23 (10), pp.5510. ⟨10.3390/ijms23105510⟩
International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5510

International audience; Extracellular vesicles (EVs) are membranous particles released by all cell types. Their role as functional carrier of bioactive molecules is boosted by cells that actively secrete them in biological fluids or in the intercellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ad4a617f3e19f9ada9b7b75860ed0a
https://pubmed.ncbi.nlm.nih.gov/35628321

Extracellular vesicle microRNAs contribute to Notch signaling pathway in T-cell acute lymphoblastic leukemia

Autor: Tommaso Colangelo, Patrizio Panelli, Francesco Mazzarelli, Francesco Tamiro, Valentina Melocchi, Elisabetta De Santis, Roberto Cuttano, Orazio Palumbo, Giovanni Rossi, Fabrizio Bianchi, Vincenzo Giambra

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive T-cell malignancy characterized by genotypically-defined and phenotypically divergent cell populations, governed by adaptive landscapes. Clonal expansions are associated to genetic and epig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113db364cfe24667c64b046fb5e4298e
https://hdl.handle.net/11573/1663582

Fetal Central Nervous System Derived Extracellular Vesicles: Potential for Non-invasive Tracking of Viral Mediated Fetal Brain Injury

Autor: Miriam Hillel, Yechiel Schlesinger, Angela J. Stephens, Alec J. Hirsch, Antonio E. Frias, Yifat Eldar-Yedidia, Nune Darbinian, Arunmani Mani, Nana Merabova, Daniel N. Streblow, Laura Goetzl, Victoria H. J. Roberts, Nicole N. Haese

Publikováno v: Frontiers in Virology, Vol 1 (2021)

Introduction: Extracellular vesicles derived from the fetal central nervous system (FCNSEs) can be purified from maternal serum or plasma using the protein Contactin-2/TAG1that is expressed almost exclusively by developing neurons in the hippocampus,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::978146681c210bdfa537e3c115e8eb27
https://doi.org/10.3389/fviro.2021.782863

Role of Exosomes in Prostate Cancer Metastasis

Autor: Sharanjot Saini, Theresa Akoto

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 3528, p 3528 (2021)

Prostate cancer remains a life-threatening disease among men worldwide. The majority of PCa-related mortality results from metastatic disease that is characterized by metastasis of prostate tumor cells to various distant organs, such as lung, liver,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284ea56b006fe07e32a1c4ae15445199
https://pubmed.ncbi.nlm.nih.gov/33805398