Zobrazeno 1 - 10
of 120
pro vyhledávání: '"exosomal PD‐L1"'
Publikováno v:
Genes and Diseases, Vol 11, Iss 1, Pp 321-334 (2024)
Exosomes are small membrane vesicles containing microRNA, RNA, DNA fragments, and proteins that are transferred from donor cells to recipient cells. Tumor cells release exosomes to reprogram the factors associated with the tumor microenvironment (TME
Externí odkaz:
https://doaj.org/article/bbfda6edd0d54c268cd755e321992b2e
Autor:
Man-Man Lu, Yu Yang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
PD-1/PD-L1 signaling is a key factor of local immunosuppression in the tumor microenvironment. Immune checkpoint inhibitors targeting PD-1/PD-L1 signaling have achieved tremendous success in clinic. However, several types of cancer are particularly r
Externí odkaz:
https://doaj.org/article/a247ec78bc8b4ff5b6c967d96b453aca
Autor:
Chenyang Zhang, Kezhen Yi, Wuwen Zhang, Chaoning Huang, Shilian Dong, Fubing Wang, Xiangheng Xiao
Publikováno v:
Advanced Sensor Research, Vol 2, Iss 3, Pp n/a-n/a (2023)
Abstract Immunotherapy has received wide attention in recent years as a new avenue for the effective treatment of cancer. However, due to the lack of detection limit and sensitivity of immune checkpoint molecule (such as Programmed cell death 1 ligan
Externí odkaz:
https://doaj.org/article/04948f42cc704f55b62857f6a53e981f
Publikováno v:
Materials & Design, Vol 227, Iss , Pp 111714- (2023)
Highly sensitive detection of melanoma-derived exosomal PD-L1 plays a key role in non-invasive diagnosis of melanoma. Here, we proposed a self-calibrated magnetic aptamer sensor (sCMAS) for sensitive detection of melanoma exosomal PD-L1, using the du
Externí odkaz:
https://doaj.org/article/894fcec436154ff5a0e45583de36acb1
Autor:
Dokyung Jung, Sanghee Shin, Sung‐Min Kang, Inseong Jung, Suyeon Ryu, Soojeong Noh, Sung‐Jin Choi, Jongwon Jeong, Beom Yong Lee, Kwang‐Soo Kim, Christine Seulki Kim, Jong Hyuk Yoon, Chan‐Hyeong Lee, Felicitas Bucher, Yong‐Nyun Kim, Sin‐Hyeog Im, Byoung‐Joon Song, Kyungmoo Yea, Moon‐Chang Baek
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 12, Pp n/a-n/a (2022)
Abstract T cell‐derived small extracellular vesicles (sEVs) exhibit anti‐cancer effects. However, their anti‐cancer potential should be reinforced to enhance clinical applicability. Herein, we generated interleukin‐2‐tethered sEVs (IL2‐sE
Externí odkaz:
https://doaj.org/article/50e0f0e66f9d4acd8f7796cac0e4289b
Autor:
Jung Min Shin, Chan‐Hyeong Lee, Soyoung Son, Chan Ho Kim, Jae Ah Lee, Hyewon Ko, Sol Shin, Seok Ho Song, Seong‐Sik Park, Ju‐Hyun Bae, Ju‐Mi Park, Eun‐Ji Choe, Moon‐Chang Baek, Jae Hyung Park
Publikováno v:
Advanced Science, Vol 9, Iss 5, Pp n/a-n/a (2022)
Abstract Despite their potent antitumor activity, clinical application of immune checkpoint inhibitors has been significantly limited by their poor response rates (
Externí odkaz:
https://doaj.org/article/47f461ab66a04e4d8a5b2484253a2d2c
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
As a classical immune checkpoint molecule, PD-L1 on the surface of tumor cells plays a pivotal role in tumor immunosuppression, primarily by inhibiting the antitumor activities of T cells by binding to its receptor PD-1. PD-1/PD-L1 inhibitors have de
Externí odkaz:
https://doaj.org/article/c3d8b6954c92422db32e81995411538a
Autor:
Chaoxu Zhang, Yibo Fan, Xiaofang Che, Min Zhang, Zhi Li, Ce Li, Shuo Wang, Ti Wen, Kezuo Hou, Xinye Shao, Yunpeng Liu, Xiujuan Qu
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Anti-PD-1 therapy has been approved for cancer treatment. However, the response rate is unsatisfactory. The expression of PD-L1 in tumor tissues is unreliable to predict the treatment response. Recent studies have suggested that exosomal PD-L1 not on
Externí odkaz:
https://doaj.org/article/c91c726644b54b1d8bed1a2443d515cc