Zobrazeno 1 - 10
of 66
pro vyhledávání: '"exhausted CD8+ T cells"'
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-29 (2024)
Abstract Ovarian cancer (OC) was the fifth leading cause of cancer death and the deadliest gynecological cancer in women. This was largely attributed to its late diagnosis, high therapeutic resistance, and a dearth of effective treatments. Clinical a
Externí odkaz:
https://doaj.org/article/8180ca28ec9e45c591345ff14d4897dd
Autor:
Qin Tian, Cheng Chen, Jinjin Lu, Xinyu Zheng, Xiuming Zhai, Yanping Yang, Ziyao Zhao, Jiangtao Hao, Ke Yang, Lilin Ye, Yifei Wang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
During chronic infection or tumorigenesis, persistent antigen stimulation contributes to the exhaustion of CD8+ T cells. Nevertheless, exhausted CD8+ T (TEX) cells still preserve certain effector function, and maintaining a reservoir of exhausted cel
Externí odkaz:
https://doaj.org/article/0cbb0ad41d814a589bc7af7004015feb
Publikováno v:
Cancer Biology & Medicine, Vol 21, Iss 6, Pp 499-512 (2024)
In exploring persistent infections and malignancies, a distinctive subgroup of CD8+ T cells, progenitor exhausted CD8+ T (Tpex) cells, has been identified. These Tpex cells are notable for their remarkable self-renewal and rapid proliferation abiliti
Externí odkaz:
https://doaj.org/article/6457ae865d2e41f69ab1168b34fe75ac
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Triple negative breast cancer (TNBC) is a heterogenous disease that disproportionately affects Black women. TNBC outcomes among Black women are dismal secondary to multiple factors, such as poor healthcare accessibility resulting in delays in diagnos
Externí odkaz:
https://doaj.org/article/49bee30d362e4cf481334f557996d97a
Autor:
Ruochan Zhang, Kun Chen, Caifeng Gong, Zhiyuan Wu, Chungui Xu, Xing-Ning Li, Fei Zhao, Dongmei Wang, Jianqiang Cai, Aiping Zhou, Chunfeng Qu
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Variated anti-cancer therapies are combined with immune checkpoint blockades (ICBs) for improving ICB therapeutic efficacy. Occurrence of tissue damage is common that triggers multiple inflammatory cytokine generation. Gastrointes
Externí odkaz:
https://doaj.org/article/23102421e6284cb388f8aff62471ef1e
Autor:
Hao Huang, Junwei Ge, Zhang Fang, Shaoxian Wu, Hongwei Jiang, Yanyan Lang, Junjun Chen, Wenlu Xiao, Bin Xu, Yingting Liu, Lujun Chen, Xiao Zheng, Jingting Jiang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Exhausted CD8+T cells represent a distinct cellular lineage that emerges during both chronic infections and cancers. Recent studies have shown that persistent antigen exposure can drive the differentiation of precursor exhausted CD8+T cells, termed T
Externí odkaz:
https://doaj.org/article/7614ba27941e454292ab66f38bb2f6e8
Autor:
Qianyu Jing, Quan Wan, Yujie Nie, Junqian Luo, Xiangyan Zhang, Lan Zhu, Huan Gui, Linzhao Li, Chenglv Wang, Shuanghui Chen, Mengjiao Wang, Haohua Yuan, Hang Lv, Runsang Pan, Qianjun Jing, Yingjie Nie
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: As psychoneuroimmunology flourishes, there is compelling evidence that depression suppresses the anti-tumor immune response, promotes the progression of cancer, and inhibits the effectiveness of cancer immunotherapy. Recent studies have
Externí odkaz:
https://doaj.org/article/802c3d67d30048b1b8d2cd8e64034dae
Akademický článek
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Autor:
Junghwa Lee, Kyungmin Lee, Hyeonjin Bae, Kunhee Lee, Solhwi Lee, Junhui Ma, Kyungjo Jo, Ijun Kim, ByulA Jee, Minyong Kang, Se Jin Im
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In chronic infections and cancer, exhausted CD8 T cells exhibit heterogeneous subpopulations. TCF1+PD-1+ progenitor exhausted CD8 T cells (Tpex) can self-renew and give rise to Tim-3+PD-1+ terminally differentiated CD8 T cells that retain their effec
Externí odkaz:
https://doaj.org/article/2a80f01110ac4e05b51841e2cd95b494
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
CD8+ T cell exhaustion is a stable dysfunctional state driven by chronic antigen stimulation in the tumor microenvironment (TME). Differentiation of exhausted CD8+ T cells (CD8+ TEXs) is accompanied by extensive transcriptional, epigenetic and metabo
Externí odkaz:
https://doaj.org/article/13e71ca48a7a464cb86074d45ade303a