Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson’s Disease

Autor: Pier G. Mastroberardino, Silvia Cerri, Yvonne Rijksen, Wilfred F. J. van IJcken, Sylvia Gabriels, Kasper W.J. Derks, Sara Sepe, Alex L. Nigg, Sandra Moreno, Fabio Blandini, Jan H.J. Hoeijmakers, César Payán-Gómez, Chiara Milanese

Publikováno v: Cell Reports, Vol 15, Iss 9, Pp 1866-1875 (2016)
Cell Reports, 15(9), 1866-1875. Cell Press
Cell Reports
Ahmad, A., Robinson, A.R., Duensing, A., van Drunen, E., Beverloo, H.B., Weisberg, D.B., Hasty, P., Niedernhofer, L.J., ERCC1-XPF endonuclease facilitates DNA double-strand break repair (2008) Mol. Cell. Biol., 28, pp. 5082-5092
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario

Summary The underlying relation between Parkinson’s disease (PD) etiopathology and its major risk factor, aging, is largely unknown. In light of the causative link between genome stability and aging, we investigate a possible nexus between DNA dama

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b0bbfe6ea60a86ed23fe21e516fdfa
https://doi.org/10.1016/j.celrep.2016.04.071

Association of ERCC1 SNPs with outcome in platinum-treated patients with advanced urothelial cancer: a Hellenic Cooperative Oncology Group study

Autor: Nikitas, N., Karadimou, A., Tsitoura, E., Soupos, N., Tsiatas, M., Karavasilis, V., Pectasides, Dimitrios, Pavlidis, Nicholas, Chrisofos, M., Adamakis, I., Murray, S., Fountzilas, George, Dimopoulos, M. A., Bamias, A. T.

Publikováno v: Pharmacogenomics

Aim: The association between two polymorphisms of ERCC1 and treatment outcomes after platinum-based chemotherapy in patients with advanced urothelial cancer (UC) was examined. Materials & methods: Genotyping of 19007C>T and 8092C>A polymorphisms was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bfc0cb1987b72088a3d20615db03225
https://doi.org/10.2217/pgs.12.162

Expression of ERCC1 and its clinicopathological correlations in non-small cell lung cancer

Autor: Levent Elmas, Vildan Caner, G. Ozan Çetin, Gulseren Bagci, Nur Büyükpınarbaşılı, Emre Tepeli, Füsun Düzcan

Publikováno v: Molecular Biology Reports. 39:335-341

Excision Repair Cross-Complementing Group 1 (ERCC1) is an important DNA repair gene, playing critical role in nucleotide excision repair pathway and having a significant influence on genomic instability. Some studies support that ERCC1 might be a pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639d35a6c14e981375eb7bff9e7cd057
https://doi.org/10.1007/s11033-011-0743-0

Prognostic utility of β-tubulin isotype III and correlations with other molecular and clinicopathological variables in patients with early breast cancer: A translational Hellenic Cooperative Oncology Group (HeCOG) study

Autor: Pentheroudakis, George, Batistatou, Anna, Kalogeras, K. T., Kronenwett, R., Wirtz, R. M., Bournakis, E., Eleftheraki, A. G., Pectasides, Dimitrios, Bobos, M., Papaspirou, I., Kamina, S., Gogas, H., Koutras, A. K., Pavlidis, Nicholas, Fountzilas, George

Publikováno v: Breast cancer research and treatment
Breast Cancer Research and Treatment
Breast Cancer Research and Treatment, Springer Verlag, 2011, 127 (1), pp.179-193. ⟨10.1007/s10549-011-1427-0⟩

We evaluated the prognostic and predictive utility of β-tubulin isotype III (TUBB3) tumour gene transcription in early breast cancer patients enrolled in a randomised study. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7973de11ace1d6dddf303afee14aa8
https://gnosis.library.ucy.ac.cy/handle/7/42338

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