Live Cell Monitoring of Phosphodiesterase Inhibition by Sulfonylurea Drugs

Autor: Filip Berisha, Stefan Blankenberg, Viacheslav O. Nikolaev

Publikováno v: Biomolecules, Vol 14, Iss 8, p 985 (2024)

Sulfonylureas (SUs) are a class of antidiabetic drugs widely used in the management of diabetes mellitus type 2. They promote insulin secretion by inhibiting the ATP-sensitive potassium channel in pancreatic β-cells. Recently, the exchange protein d

Externí odkaz: https://doaj.org/article/c9fc437b02d84761aba4c7f8afe63f8b

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Soluble adenylyl cyclase regulates the cytosolic NADH/NAD+ redox state and the bioenergetic switch between glycolysis and oxidative phosphorylation

Autor: Lonny R. Levin, Arthur J. Verhoeven, Eduardo H. Gilglioni, Hang Lam Li, Richard J. Rodenburg, Simei Go, Daan M. Panneman, Jung-Chin Chang, Ronald P.J. Oude Elferink, Suzanne Duijst, Jochen Buck, Hsu-Li Huang

Publikováno v: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1862(4):148367. Elsevier
Biochimica et Biophysica Acta. Bioenergetics, 1862, 4
Biochimica et Biophysica Acta. Bioenergetics, 1862

Contains fulltext : 231545.pdf (Publisher’s version ) (Open Access) The evolutionarily conserved soluble adenylyl cyclase (sAC, ADCY10) mediates cAMP signaling exclusively in intracellular compartments. Because sAC activity is sensitive to local co

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https://pure.amc.nl/en/publications/soluble-adenylyl-cyclase-regulates-the-cytosolic-nadhnad-redox-state-and-the-bioenergetic-switch-between-glycolysis-and-oxidative-phosphorylation(ace0b296-6c12-4419-92dd-6d7f8c2e96c4).html

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Distinct PKA and Epac compartmentalization in airway function and plasticity

Publikováno v: Pharmacology & Therapeutics. 137(2):248-265

Asthma and chronic obstructive pulmonary disease (COPD) are obstructive lung diseases characterized by airway obstruction, airway inflammation and airway remodelling. Next to inflammatory cells and airway epithelial cells, airway mesenchymal cells, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___01423::a2a50d1009a2e55c0bf1dec73c5c78e4
https://doi.org/10.1016/j.pharmthera.2012.10.006