The Complexity of Bariatric Patient’s Pharmacotherapy: Sildenafil Biopharmaceutics and Pharmacokinetics before vs. after Gastric Sleeve/Bypass

Autor: Daniel Porat, Oleg Dukhno, Sandra Cvijić, Arik Dahan

Publikováno v: Pharmaceutics, Vol 15, Iss 12, p 2795 (2023)

Postbariatric altered gastrointestinal (GI) anatomy/physiology may significantly harm oral drug absorption and overall bioavailability. In this work, sildenafil, the first phosphodiesterase-5 (PDE5) inhibitor, was investigated for impaired postbariat

Externí odkaz: https://doaj.org/article/d5bd77dadbb446c7b74fd9f76df2ccab

Exploring porcine gastric and intestinal fluids using microscopic and solubility estimates: Impact of placebo self-emulsifying drug delivery system administration to inform bio-predictive in vitro tools.

Autor: Bennett-Lenane, Harriet¹ (AUTHOR), Jørgensen, Jacob R.² (AUTHOR), Koehl, Niklas J.¹ (AUTHOR), Henze, Laura J.¹ (AUTHOR), O'Shea, Joseph P.¹ (AUTHOR), Müllertz, Anette² (AUTHOR), Griffin, Brendan T.¹ (AUTHOR) brendan.griffin@ucc.ie

Publikováno v: European Journal of Pharmaceutical Sciences. Jun2021, Vol. 161, pN.PAG-N.PAG. 1p.

Exploring Porcine Gastric and Intestinal Fluids using Microscopic and Solubility Estimates:Impact of Placebo Self-Emulsifying Drug Delivery System Administration to Inform Bio-Predictive in vitro Tools

Autor: Laura J. Henze, Joseph P. O'Shea, Jacob Rune Jørgensen, Niklas J. Koehl, Harriet Bennett-Lenane, Anette Müllertz, Brendan T. Griffin

Publikováno v: Bennett-Lenane, H, Jørgensen, J R, Koehl, N J, Henze, L J, O'Shea, J P, Müllertz, A & Griffin, B T 2021, ' Exploring Porcine Gastric and Intestinal Fluids using Microscopic and Solubility Estimates : Impact of Placebo Self-Emulsifying Drug Delivery System Administration to Inform Bio-Predictive in vitro Tools ', European Journal of Pharmaceutical Sciences, vol. 161, 105778 . https://doi.org/10.1016/j.ejps.2021.105778

Validation and characterisation of in vitro and pre-clinical animal models to support bio-enabling formulation development is of paramount importance. In this work, post-mortem gastric and small intestinal fluids were collected in the fasted, fed sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4fb52694411d08daffa803bad79c3bc
https://curis.ku.dk/ws/files/263034089/1_s2.0_S0928098721000804_main.pdf

Культуральні властивості кріоконсервованих мультипотентних стромальних клітин тимуса і фетальних клітин шкірно-м'язового походження (Ukrainian)

Autor: Нікольська, В. В., Семенова, Я.-М. О., Тарануха, Л. І., Нікольський, І. С.

Publikováno v: Problems of Cryobiology & Cryomedicine / Problemy Kriobiologii i Kriomediciny; 2021, Vol. 31 Issue 3, p249-257, 9p

Mathematical modeling of oral absorption and bioavailability of a fluoroquinolone after its precipitation in the gastrointestinal tract.

Autor: Fernandez-Teruel, C.¹ (AUTHOR) mbermejo@umh.es, Mangas-Sanjuan, V.² (AUTHOR), Gonzalez-Alvarez, I.² (AUTHOR), Ruiz-Garcia, A.¹ (AUTHOR), Casabó, V. G.¹ (AUTHOR), Bermejo, M.² (AUTHOR)

Publikováno v: Xenobiotica. Sep2013, Vol. 43 Issue 9, p745-754. 10p.