Zobrazeno 1 - 10
of 218
pro vyhledávání: '"evofosfamide"'
Autor:
Tet Woo Lee, Dean C. Singleton, Julia K. Harms, Man Lu, Sarah P. McManaway, Amy Lai, Moana Tercel, Frederik B. Pruijn, Andrew M. J. Macann, Francis W. Hunter, William R. Wilson, Stephen M. F. Jamieson
Publikováno v:
Molecular Oncology, Vol 18, Iss 8, Pp 1885-1903 (2024)
Tumour hypoxia promotes poor patient outcomes, with particularly strong evidence for head and neck squamous cell carcinoma (HNSCC). To effectively target hypoxia, therapies require selection biomarkers and preclinical models that can accurately model
Externí odkaz:
https://doaj.org/article/8463ca23a4994262a7d8bf8b809ac374
Akademický článek
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Autor:
Michal R. Tomaszewski, Shuxuan Fan, Alberto Garcia, Jin Qi, Youngchul Kim, Robert A. Gatenby, Matthew B. Schabath, William D. Tap, Denise K. Reinke, Rikesh J. Makanji, Damon R. Reed, Robert J. Gillies
Publikováno v:
Tomography, Vol 8, Iss 1, Pp 341-355 (2022)
Purpose: Success of clinical trials increasingly relies on effective selection of the target patient populations. We hypothesize that computational analysis of pre-accrual imaging data can be used for patient enrichment to better identify patients wh
Externí odkaz:
https://doaj.org/article/b7bfcc234f824a8f824df183331d4c45
Akademický článek
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Autor:
Alessia Lodi, Renu Pandey, Jennifer Chiou, Ayon Bhattacharya, Shiliang Huang, Xingxin Pan, Brandon Burgman, S. Stephen Yi, Stefano Tiziani, Andrew J. Brenner
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastomas (GBM) are the most common and aggressive form of primary malignant brain tumor in the adult population, and, despite modern therapies, patients often develop recurrent disease, and the disease remains incurable with median survival belo
Externí odkaz:
https://doaj.org/article/8d649ef526fa419aa6476b5269c3dcc0
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-4 (2018)
Abstract Background Quantitative imaging can facilitate patient stratification in clinical trials. The hypoxia-activated prodrug evofosfamide recently failed a phase III trial in pancreatic cancer. However, the study did not attempt to select for pat
Externí odkaz:
https://doaj.org/article/9677037b00144563a5848dafe17d01ee
Akademický článek
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Publikováno v:
Cells, Vol 10, Iss 5, p 1006 (2021)
The magnitude of the host immune response can be regulated by either stimulatory or inhibitory immune checkpoint molecules. Receptor-ligand binding between inhibitory molecules is often exploited by tumours to suppress anti-tumour immune responses. I
Externí odkaz:
https://doaj.org/article/005f909081724a54accec5e2af897a59
Publikováno v:
Expert Opinion on Therapeutic Patents. 32(1):1-12
Introduction The hypoxic tumor microenvironment represents a persistent obstacle in the treatment of most solid tumors. In the past years, significant efforts have been made to improve the efficacy of anti-cancer drugs. Therefore, hypoxia-activated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od________83::2a5830dac32f90fb0b324b38e0ccbdf1
https://cris.maastrichtuniversity.nl/en/publications/1b7645b2-195e-4eda-a012-380a65bf5e9c
https://cris.maastrichtuniversity.nl/en/publications/1b7645b2-195e-4eda-a012-380a65bf5e9c
Publikováno v:
Expert Opinion on Therapeutic Patents
Introduction The hypoxic tumor microenvironment represents a persistent obstacle in the treatment of most solid tumors. In the past years, significant efforts have been made to improve the efficacy of anti-cancer drugs. Therefore, hypoxia-activated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c258c4ab3466de482ea7c02ad12516dc
https://doi.org/10.1080/13543776.2021.1954617
https://doi.org/10.1080/13543776.2021.1954617