フランス国立図書館蔵「酒飯論絵巻」の特徴と文化庁本の翻刻 (共同研究報告)

Autor: et les autres, ITO, Nobuhiro, 他 共同研究メンバー, 伊藤, 信博

Externí odkaz: http://www.lang.nagoya-u.ac.jp/research.html
http://hdl.handle.net/2237/18903

Safety, tolerability, and efficacy of fasudil in amyotrophic lateral sclerosis (ROCK-ALS): a phase 2, randomised, double-blind, placebo-controlled trial.

Autor: Koch JC; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany., Leha A; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany., Bidner H; Münchner Studienzentrum, Technical University Munich, School of Medicine and Health, Munich, Germany., Cordts I; Department of Neurology, Klinikum rechts der Isar, Technical University Munich, School of Medicine and Health, Munich, Germany., Dorst J; Department of Neurology, Ulm University, Ulm, Germany., Günther R; Department of Neurology, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany; German Centre for Neurodegenerative Diseases, Site Dresden, Dresden, Germany., Zeller D; Department of Neurology, University Hospital Würzburg, Würzburg, Germany., Braun N; Neuromuscular Diseases Unit/ALS Clinic, Cantonal Hospital St Gallen, St Gallen, Switzerland., Metelmann M; Department of Neurology, University Hospital Leipzig, Leipzig, Germany., Corcia P; Centre de Référence Maladie Rare (CRMR) SLA et les Autres Maladies du Neurone Moteur (FILSLAN), Tours, France; Faculté de Médecine, INSERM U1253, 'iBrain Imaging Brain and Neuropsychiatry' Université François-Rabelais de Tours, Tours, France., De La Cruz E; ALS centre, CHU Gui de Chauliac, Univ Montpellier, INM, INSERM, Montpellier, France., Weydt P; Department for Neuromuscular Disorders, University Hospital Bonn, Bonn, Germany; German Centre for Neurodegenerative Diseases, Site Bonn, Bonn, Germany., Meyer T; Department of Neurology, Center for ALS and Other Motor Neuron Disorders, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Großkreutz J; Department of Neurology, Jena University Hospital, Jena, Germany; Precision Neurology of Neuromuscular and Motoneuron Diseases, University of Lübeck, Lübeck, Germany., Soriani MH; ALS Reference Centre, Pasteur 2 Hospital, CHU de Nice, Université Côte d'Azur, UMR2CA, Nice, France., Attarian S; Neuromuscular Disease and ALS Reference Center, Timone University Hospital, Aix-Marseille University, CHU Timone, Marseille, France., Weishaupt JH; Division for Neurodegenerative Diseases, Neurology Department, Mannheim Center for Translational Medicine, University Medicine Mannheim, Heidelberg University, Mannheim, Germany., Weyen U; Department of Neurology, Ruhr-University Bochum, BG-Kliniken Bergmannsheil, Bochum, Germany., Kuttler J; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany., Zurek G; MVZ Medizinisches Labor Bremen GmbH, Bremen, Germany., Rogers ML; MND&NR Lab, FHMRI, College of Medicine and Public health, Flinders University, Bedford Park, Adelaide, SA, Australia., Feneberg E; Department of Neurology, Klinikum rechts der Isar, Technical University Munich, School of Medicine and Health, Munich, Germany., Deschauer M; Department of Neurology, Klinikum rechts der Isar, Technical University Munich, School of Medicine and Health, Munich, Germany., Neuwirth C; Neuromuscular Diseases Unit/ALS Clinic, Cantonal Hospital St Gallen, St Gallen, Switzerland., Wuu J; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Ludolph AC; Department of Neurology, Ulm University, Ulm, Germany; German Center for Neurodegenerative Diseases, Site Ulm, Ulm, Germany., Schmidt J; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany; Department of Neurology and Pain Treatment, Neuromuscular Center, Center for Translational Medicine, Immanuel University Hospital Rüdersdorf, Brandenburg Medical School Theodor Fontane, Rüdersdorf bei Berlin, Berlin, Germany; Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Rüdersdorf bei Berlin, Berlin, Germany., Remane Y; Central Pharmacy, Leipzig University Medical Center, Leipzig, Germany., Camu W; ALS centre, CHU Gui de Chauliac, Univ Montpellier, INM, INSERM, Montpellier, France., Friede T; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany., Benatar M; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Weber M; Neuromuscular Diseases Unit/ALS Clinic, Cantonal Hospital St Gallen, St Gallen, Switzerland., Lingor P; Department of Neurology, Klinikum rechts der Isar, Technical University Munich, School of Medicine and Health, Munich, Germany; German Center for Neurodegenerative Diseases, Site Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Electronic address: paul.lingor@tum.de.

Publikováno v: The Lancet. Neurology [Lancet Neurol] 2024 Nov; Vol. 23 (11), pp. 1133-1146.

Author Correction: The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration.

Autor: Opie-Martin S; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Iacoangeli A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK.; Department of Biostatistics and Health Informatics, Institute of Psychiatry Psychology & Neuroscience, King's College London, SE5 8AF, London, UK.; NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK., Topp SD; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Abel O; Homerton University Hospital, Homerton Row, London, E9 6SR, UK., Mayl K; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Mehta PR; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Shatunov A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK.; Department of Molecular and Clinical Pharmacology, University of Liverpool, Blue Block 1.09, Sherrington Building, Crown St, Liverpool, L693BX, UK.; Institute of Medicine, North-Eastern Federal University, 58 Belinsky str, Yakutsk, 677000, Russia., Fogh I; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Bowles H; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Limbachiya N; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Spargo TP; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Al-Khleifat A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Williams KL; Macquarie University Centre for MND Research, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia., Jockel-Balsarotti J; Department of Neurology, Washington University School of Medicine, St Louis, MO, 63110, USA., Bali T; Department of Neurology, Washington University School of Medicine, St Louis, MO, 63110, USA., Self W; Department of Neurology, Washington University School of Medicine, St Louis, MO, 63110, USA., Henden L; Macquarie University Centre for MND Research, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia., Nicholson GA; Macquarie University Centre for MND Research, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.; Concord Clinical School, ANZAC Research Institute, Concord Repatriation Hospital, Sydney, NSW, 2139, Australia., Ticozzi N; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, 20095, Cusano Milanino, MiIan, Italy.; Dino Ferrari Center, Department of Pathophysiology and Transplantation, Center for Neurotechnology and Brain Therapeutics, Università degli Studi di Milano, Milan, Italy., McKenna-Yasek D; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, 02125, USA., Tang L; Department of Neurology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, PR China., Shaw PJ; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, S10 2HQ, UK., Chio A; Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.; Neurology 1, AOU Città della Salute e della Scienza of Torino, Turin, 10124, Torino, Italy., Ludolph A; Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany.; German Center for Neurodegenerative Diseases, DZNE, Ulm, Germany., Weishaupt JH; Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.; Division of Neurodegenerative Disorders, Department of Neurology, Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany., Landers JE; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, 02125, USA., Glass JD; Department Neurology, Emory University School of Medicine, Atlanta, GA, 30322, USA., Mora JS; ALS Unit, Department of Neurology, Hospital San Rafael, 28016, Madrid, Spain., Robberecht W; Neurology Department, Univeristy Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium., Damme PV; Neurology Department, Univeristy Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.; Neuroscience Department, KU Leuven and Center for Brain & Disease Research VIB Leuven, Leuven, Belgium., McLaughlin R; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, D02 PN40, Ireland., Hardiman O; Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, D02 PN40, Ireland., van den Berg L; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands., Veldink JH; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands., Corcia P; Centre de Référence pour la SLA et les Autres Maladies du Motoneurone (FILSLAN), 2 Avenue Martin Luther King, 87042, Limoges Cedex, France.; Centre de Compétences Neuropathies Amyloïdes Familiales et Autres Neuropathies Périphériques Rares (NNERF), Poitiers, France., Stevic Z; Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Studentski trg 1, Belgrade, Serbia., Siddique N; Neuromuscular Disorders Program, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60208, USA., Silani V; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, 20095, Cusano Milanino, MiIan, Italy.; Dino Ferrari Center, Department of Pathophysiology and Transplantation, Center for Neurotechnology and Brain Therapeutics, Università degli Studi di Milano, Milan, Italy., Blair IP; Macquarie University Centre for MND Research, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia., Fan DS; Department of Neurology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, PR China., Esselin F; Reference Center for ALS and Other Rare Motoneuron Disorders, University Hospital Gui de Chauliac, 34295, Montpellier, France., de la Cruz E; Reference Center for ALS and Other Rare Motoneuron Disorders, University Hospital Gui de Chauliac, 34295, Montpellier, France., Camu W; Reference Center for ALS and Other Rare Motoneuron Disorders, University Hospital Gui de Chauliac, 34295, Montpellier, France., Basak NA; Koç University, School of Medicine Translational Medicine Research Center KUTTAM-NDAL, 34450, Sarıyer, Istanbul, Turkey., Siddique T; Neuromuscular Disorders Program, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60208, USA., Miller T; Department of Neurology, Washington University School of Medicine, St Louis, MO, 63110, USA., Brown RH; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, 02125, USA., Al-Chalabi A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Shaw CE; UK Dementia Research Institute Centre at King's College London, School of Neuroscience, King's College London, Strand, London, WC2R 2LS, UK. chris.shaw@kcl.ac.uk.; Centre for Brain Research, University of Auckland, 85 Park Road, Grafton, Auckland, 1023, New Zealand. chris.shaw@kcl.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2024 Jul 02; Vol. 15 (1), pp. 5560. Date of Electronic Publication: 2024 Jul 02.

The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration.

Autor: Opie-Martin S; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Iacoangeli A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK.; Department of Biostatistics and Health Informatics, Institute of Psychiatry Psychology & Neuroscience, King's College London, SE5 8AF, London, UK.; NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, UK., Topp SD; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Abel O; Homerton University Hospital, Homerton Row, London, E9 6SR, UK., Mayl K; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Mehta PR; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Shatunov A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK.; Department of Molecular and Clinical Pharmacology, University of Liverpool, Blue Block 1.09, Sherrington Building, Crown St, Liverpool, L693BX, UK.; Institute of Medicine, North-Eastern Federal University, 58 Belinsky str, Yakutsk, 677000, Russia., Fogh I; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Bowles H; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Limbachiya N; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Spargo TP; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Al-Khleifat A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Williams KL; Macquarie University Centre for MND Research, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia., Jockel-Balsarotti J; Department of Neurology, Washington University School of Medicine, St Louis, MO, 63110, USA., Bali T; Department of Neurology, Washington University School of Medicine, St Louis, MO, 63110, USA., Self W; Department of Neurology, Washington University School of Medicine, St Louis, MO, 63110, USA., Henden L; Macquarie University Centre for MND Research, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia., Nicholson GA; Macquarie University Centre for MND Research, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.; Concord Clinical School, ANZAC Research Institute, Concord Repatriation Hospital, Sydney, NSW, 2139, Australia., Ticozzi N; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, 20095, Cusano Milanino, MiIan, Italy.; Dino Ferrari Center, Department of Pathophysiology and Transplantation, Center for Neurotechnology and Brain Therapeutics, Università degli Studi di Milano, Milan, Italy., McKenna-Yasek D; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, 02125, USA., Tang L; Department of Neurology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, PR China., Shaw PJ; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, S10 2HQ, UK., Chio A; Rita Levi Montalcini' Department of Neuroscience, University of Turin, Turin, Italy.; Neurology 1, AOU Città della Salute e della Scienza of Torino, Turin, 10124, Torino, Italy., Ludolph A; Department of Neurology, Ulm University, Oberer Eselsberg 45, 89081, Ulm, Germany.; German Center for Neurodegenerative Diseases, DZNE, Ulm, Germany., Weishaupt JH; Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.; Division of Neurodegenerative Disorders, Department of Neurology, Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany., Landers JE; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, 02125, USA., Glass JD; Department Neurology, Emory University School of Medicine, Atlanta, GA, 30322, USA., Mora JS; ALS Unit, Department of Neurology, Hospital San Rafael, 28016, Madrid, Spain., Robberecht W; Neurology Department, Univeristy Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium., Damme PV; Neurology Department, Univeristy Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.; Neuroscience Department, KU Leuven and Center for Brain & Disease Research VIB Leuven, Leuven, Belgium., McLaughlin R; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, D02 PN40, Ireland., Hardiman O; Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, D02 PN40, Ireland., van den Berg L; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands., Veldink JH; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands., Corcia P; Centre de Référence pour la SLA et les Autres Maladies du Motoneurone (FILSLAN), 2 Avenue Martin Luther King, 87042, Limoges Cedex, France.; Centre de Compétences Neuropathies Amyloïdes Familiales et Autres Neuropathies Périphériques Rares (NNERF), Poitiers, France., Stevic Z; Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Studentski trg 1, Belgrade, Serbia., Siddique N; Neuromuscular Disorders Program, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60208, USA., Silani V; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, 20095, Cusano Milanino, MiIan, Italy.; Dino Ferrari Center, Department of Pathophysiology and Transplantation, Center for Neurotechnology and Brain Therapeutics, Università degli Studi di Milano, Milan, Italy., Blair IP; Macquarie University Centre for MND Research, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia., Fan DS; Department of Neurology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, PR China., Esselin F; Reference Center for ALS and Other Rare Motoneuron Disorders, University Hospital Gui de Chauliac, 34295, Montpellier, France., de la Cruz E; Reference Center for ALS and Other Rare Motoneuron Disorders, University Hospital Gui de Chauliac, 34295, Montpellier, France., Camu W; Reference Center for ALS and Other Rare Motoneuron Disorders, University Hospital Gui de Chauliac, 34295, Montpellier, France., Basak NA; Koç University, School of Medicine Translational Medicine Research Center KUTTAM-NDAL, 34450, Sarıyer, Istanbul, Turkey., Siddique T; Neuromuscular Disorders Program, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60208, USA., Miller T; Department of Neurology, Washington University School of Medicine, St Louis, MO, 63110, USA., Brown RH; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, 02125, USA., Al-Chalabi A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9NU, UK., Shaw CE; UK Dementia Research Institute Centre at King's College London, School of Neuroscience, King's College London, Strand, London, WC2R 2LS, UK. chris.shaw@kcl.ac.uk.; Centre for Brain Research, University of Auckland, 85 Park Road, Grafton, Auckland, 1023, New Zealand. chris.shaw@kcl.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2022 Nov 12; Vol. 13 (1), pp. 6901. Date of Electronic Publication: 2022 Nov 12.