Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

Autor: Inês Barroso, Peter D. Sly, Jose Ramon Bilbao, Nicholas J. Timpson, Johan G. Eriksson, Maria M. Groen-Blokhuis, Sijmen A. Reijneveld, Dariusz Gruszfeld, George Davey Smith, Christine Power, Eva Reischl, Mandy Vogel, Andrew T. Hattersley, Øyvind Helgeland, Niina Pitkänen, Akram Alyass, Jean-Paul Langhendries, Elina Hyppönen, Kathrin Landgraf, Loreto Santa-Marina, Frank Geller, Christopher D. Brown, Elvira Verduci, Katja Pahkala, Olli T. Raitakari, Joaquin Escribano, Torben Hansen, Hakon Hakonarson, Barbara Heude, Bridget A. Knight, Maties Torrent, Robin N Beaumont, Judith M. Vonk, Estelle Lowry, Patrick G. Holt, Harold Snieder, Carol A. Wang, Mark I. McCarthy, Christine Frithioff-Bøjsøe, Tanja G. M. Vrijkotte, Natalia Vilor-Tejedor, Lisbeth Carstensen, Catharina E. M. van Beijsterveldt, Ville Karhunen, Virpi Lindi, Marjo-Riitta Järvelin, Tarunveer S. Ahluwalia, Jordi Sunyer, Jaakko T. Leinonen, Clare S. Murray, Klaus Bønnelykke, Thorkild I. A. Sørensen, André G. Uitterlinden, Janine F. Felix, John A. Curtin, Mika Kähönen, Jorma Viikari, Leo-Pekka Lyytikäinen, Oluf Pedersen, Carmen Iñiguez, Harri Niinikoski, Wieland Kiess, Kim F. Michaelsen, Evie Stergiakouli, Anni Heiskala, Alessandra Chesi, Craig E. Pennell, Mohammed H Zafarmand, Peter Rzehak, Kook K Teo, Aihuali Li, Marie Standl, Veit Grote, Momoko Horikoshi, Ellen A. Nohr, Eleanor Wheeler, Rachel M. Freathy, Iryna O. Fedko, Gerard H. Koppelman, Elisabeth Widen, Jens-Christian Holm, Raimo Joro, David Meyre, Mustafa Atalay, Theresia M. Schnurr, Camilla Schmidt Morgen, Adnan Custovic, Niels Grarup, Trevor A. Mori, Terho Lehtimäki, Christian Theil Have, Angela Simpson, Mads Melbye, Bjarke Feenstra, Lawrence J. Beilin, Stefan Johansson, Ioanna Ntalla, Martine Vrijheid, Mariona Bustamante, George Dedoussis, Sylvain Sebert, Jonas Bacelis, Carolina Medina-Gomez, Elisabeth Thiering, Ken K. Ong, Eleftheria Zeggini, Berthold Koletzko, Karine Clément, Bo L. Chawes, Mette Hollensted, Babette S. Zemel, Markus Scholz, Holger Kirsten, Antje Körner, Albertine J. Oldehinkel, Barbera D. C. van Schaik, Philippe Froguel, Vincent W. V. Jaddoe, Dorret I. Boomsma, Struan F.A. Grant, Loic Yengo, Jonathan P. Bradfield, Tenna Ruest Haarmark Nielsen, Suzanne Vogelezang, Jakob Stokholm, Pål R. Njølstad, Bo Jacobsson, Marc Vaudel, Peter J. van der Most, Andreas Kühnapfel, Mads Vendelbo Lind, Timo A. Lakka, Saskia Selzam, Robert Plomin, Marie-Aline Charles, Jouke-Jan Hottenga, Kalliope Panoutsopoulou, Fernando Rivadeneira, Rebecca K. Vinding, Hans Bisgaard, I. S. Farooqi, Joachim Heinrich, Diana L. Cousminer, Ricardo Closa-Monasterolo, Claire Monnereau

Publikováno v: PLoS Genetics, Vol 16, Iss 10, p e1008718 (2020)
PLoS Genetics
Addi. Archivo Digital para la Docencia y la Investigación
instname
Vogelezang, S, Bradfield, J P, Ahluwalia, T S, Curtin, J A, Grarup, N, Schnurr, T M, Hansen, T, Michaelsen, K F, Pedersen, O B, Stokholm, J, Lind, M V, Frithioff-Bøjsøe, C, Holm, J-C, Felix, J F & Early Growth Genetics Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', P L o S Genetics, vol. 16, no. 10, e1008718 . https://doi.org/10.1371/journal.pgen.1008718
Vogelezang, S, Bradfield, J P, Ahluwalia, T S, Curtin, J A, Lakka, T A, Grarup, N, Scholz, M, van der Most, P J, Monnereau, C, Stergiakouli, E, Heiskala, A, Horikoshi, M, Fedko, I O, Vilor-Tejedor, N, Cousminer, D L, Standl, M, Wang, C A, Viikari, J, Geller, F, Íñiguez, C, Pitkänen, N, Chesi, A, Bacelis, J, Yengo, L, Torrent, M, Ntalla, I, Helgeland, Ø, Selzam, S, Vonk, J M, Zafarmand, M H, Heude, B, Farooqi, I S, Alyass, A, Beaumont, R N, Have, C T, Rzehak, P, Bilbao, J R, Schnurr, T M, Barroso, I, Bønnelykke, K, Beilin, L J, Carstensen, L, Charles, M A, Chawes, B, Clément, K, Closa-Monasterolo, R, Custovic, A, Hansen, T, Morgen, C S, Nohr, E A & Early Growth Genetics Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PLOS Genetics, vol. 16, no. 10, e1008718 . https://doi.org/10.1371/journal.pgen.1008718
PLOS Genetics
PLoS Genetics (online), 16(10):e1008718. Public Library of Science
PLoS genetics, 16(10):e1008718. Public Library of Science
PLoS Genetics, Public Library of Science, 2020, 16 (10), pp.e1008718. ⟨10.1371/journal.pgen.1008718⟩
e1008718
PLOS GENETICS
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Fedko, I O, Groen-Blokhuis, M, Hottenga, J-J, Van Beijsterveldt, C E M, Vrijkotte, T G M, Boomsma, D I & Early Growth Genetics (EGG) Consortium 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PLoS Genetics, vol. 16, no. 10, e1008718, pp. 1-26 . https://doi.org/10.1371/journal.pgen.1008718
PLoS Genetics, 2020, 16 (10), pp.e1008718. ⟨10.1371/journal.pgen.1008718⟩
PLoS Genetics, 16(10):e1008718, 1-26. Public Library of Science
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
r-FISABIO. Repositorio Institucional de Producción Científica
Curtin, J, Murray, C & et al. 2020, ' Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits ', PL o S Genetics . https://doi.org/10.1371/journal.pgen.1008718
PLoS genetics, 16(10):e1008718. PUBLIC LIBRARY SCIENCE
PLoS Genet. 16:e1008718 (2020)

The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7e3e9c63ac8faa6aa819187732da43
https://doi.org/10.1371/journal.pgen.1008718

Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain

Autor: Elena Muiño, Victor Obach, Ana Calleja, Elena López-Cancio, Reyes de Torres-Chacón, Jara Cárcel-Márquez, Joan Martí-Fàbregas, Serafí Cambray, Maria Del Mar Freijo, Jerzy Krupinski, Maria-Teresa Buongiorno, Israel Fernandez-Cadenas, Natalia Cullell, Joan Montaner, Sarah Besora, Jessica Molina, Manuel Rodríguez-Yáñez, Silvia Tur, Jonathan González-Sánchez, Cristina Gallego-Fabrega, María Hernández-Pérez, Eva Giralt-Steinhauer, Javier Sotoca, José Castillo, Nuria-Paz Torres-Aguila, Jordi Jimenez-Conde, Caty Carrera, Maria-Àngels Font, Juan Antonio Cabezas, Francisco Purroy, Fernando Mancha, Tomás Sobrino, Cristofol Vives-Bauza, Juan F. Arenillas, Luis Prats-Sánchez, Pol Camps-Renom

Publikováno v: Repositorio Abierto de la UdL
Universitad de Lleida
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname

Acenocoumarol is an oral anticoagulant with significant interindividual dose variations. Variants in CYP2C9 and VKORC1 have been associated with acenocoumarol maintenance dose. We analysed whether any of the 49 polymorphisms in CYP2C9 and VKORC1 prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30596eb8e882d6d90f34f88d12eacce8
https://doi.org/10.1038/s41598-020-59641-9

Blood cell transcriptomic-based early biomarkers of adverse programming effects of gestational calorie restriction and their reversibility by leptin supplementation

Autor: Andreu Palou, Jadwiga Konieczna, Juana Sánchez, Catalina Picó, Mariona Palou

Publikováno v: Scientific Reports

The challenge of preventing major chronic diseases requires reliable, early biomarkers. Gestational mild undernutrition in rats is enough to program the offspring to develop later pathologies; the intake of leptin, a breastmilk component, during lact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f74b1a5a4facc3b14d3654a1ec463c1
https://doi.org/10.1038/srep09088

DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease

Autor: Marilyn Foreman, Arkadiusz Sitek, Marc Willis, L. Alexandre Frigini, Emily Wan, John Newell, Jørgen Vestbo, Raul San Jose Estepar, Jin Hwa Lee, Gregory Kinney, Yuriy Feshchenko, Frank Sciurba, Eric Hoffman, Mitja Košnik, Robert Wise, Jeffrey Curtis, Merry-Lynn McDonald

Publikováno v: Lee, J H, McDonald, M-L N, Cho, M H, Wan, E S, Castaldi, P J, Hunninghake, G M, Marchetti, N, Lynch, D A, Crapo, J D, Lomas, D A, Coxson, H O, Bakke, P S, Silverman, E K, Hersh, C P, COPDGene and ECLIPSE Investigators & Mattheisen, M 2014, ' DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease ' Respiratory Research Review, vol. 15, pp. 97 . https://doi.org/10.1186/s12931-014-0097-y
Respiratory Research

Background: Chronic obstructive pulmonary disease (COPD) is characterized by expiratory flow limitation, causing air trapping and lung hyperinflation. Hyperinflation leads to reduced exercise tolerance and poor quality of life in COPD patients. Total

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20bb41484c5ba5b85134e35e42abca0c
https://doi.org/10.1186/s12931-014-0097-y

Fine mapping and functional analysis of the multiple sclerosis risk gene CD6

Autor: Rafael Arroyo, Bhairavi Swaminathan, Elena Urcelay, David Otaegui, Mª Jesus Pinto-Medel, Antonio Alcina, Koen Vandenbroeck, Alfredo Antigüedad, Fuencisla Matesanz, Miguel Lucas, María García-Barcina, María Fedetz, Oscar Fernandez, Eva Tolosa, Angelica Cuapio, Teresa Órpez, Javier Olascoaga, Miguel A. Ortiz, Iraide Alloza, Jorge R. Oksenberg

Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
instname
PLoS ONE, Vol 8, Iss 4, p e62376 (2013)
Digital.CSIC. Repositorio Institucional del CSIC
PLoS ONE

Art. nº e62376; v. 8; issue 4
CD6 has recently been identified and validated as risk gene for multiple sclerosis (MS), based on the association of a single nucleotide polymorphism (SNP), rs17824933, located in intron 1. CD6 is a cell surface sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af79595eb41455e4e73999619bb05493
https://hdl.handle.net/10668/1362