Zobrazeno 1 - 10
of 712
pro vyhledávání: '"erastin"'
Autor:
Simona D’Aprile, Simona Denaro, Alessandro Lavoro, Saverio Candido, Sebastiano Giallongo, Filippo Torrisi, Lucia Salvatorelli, Giacomo Lazzarino, Angela Maria Amorini, Giuseppe Lazzarino, Gaetano Magro, Daniele Tibullo, Massimo Libra, Cesarina Giallongo, Nunzio Vicario, Rosalba Parenti
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Glioblastoma (GBM) represents an aggressive brain tumor, characterized by intra- and inter-tumoral heterogeneity and therapy resistance, leading to unfavourable prognosis. An increasing number of studies pays attention on the regulation of f
Externí odkaz:
https://doaj.org/article/7eaa9777b99146f5a184b1842ad52832
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 13, Iss 2, Pp 77-83 (2024)
Introduction. Improving the efficacy of chemotherapy is a non-trivial task of modern oncology. Its successful solution requires knowledge in many fields, including physiology, pathology, clinical oncology, pharmacology and others. The search for smal
Externí odkaz:
https://doaj.org/article/82f0498b2a064c9fb1b1135583594d0a
Autor:
Wen-Ting Li, Xin Jin, Sheng-Jie Song, Chong Wang, Chuang Fu, Wen Jiang, Jie Bai, Zhi-Zhou Shi
Publikováno v:
Animal Cells and Systems, Vol 28, Iss 1, Pp 237-250 (2024)
ABSTRACTThe role of ferroptosis-associated gene SLC7A11 in esophageal cancer progression is largely unknown, therefore, the effects of blocking SLC7A11 on esophageal squamous cell carcinoma (ESCC) cells are evaluated. Results showed that SLC7A11 was
Externí odkaz:
https://doaj.org/article/64dd97c009fd4ca3a3ff37d2838c93b5
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Lung adenocarcinoma (LUAD), the most common and lethal subtype of lung cancer, continues to be a major health concern worldwide. Despite advances in targeted and immune therapies, only a minority of patients derive substantial ben
Externí odkaz:
https://doaj.org/article/9ed98201b59044488db49e923c44098f
Autor:
Fan Wu, Fei Huang, Nili Jiang, Jinfeng Su, Siyi Yao, Boying Liang, Wen Li, Tengyue Yan, Sufang Zhou, Qingniao Zhou
Publikováno v:
BMC Urology, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Few studies are focusing on the mechanism of erastin acts on prostate cancer (PCa) cells, and essential ferroptosis-related genes (FRGs) that can be PCa therapeutic targets are rarely known. Methods In this study, in vitro assays
Externí odkaz:
https://doaj.org/article/76d9d8b0733a41789fb4a49622fd2dc0
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35457- (2024)
Aim: Ovarian cancer (OC) is the most lethal gynecological malignancy, which seriously affects the prognosis and life quality of female patients. Therefore, new therapeutic targets and treatments are urgently needed. Methods: Expression levels of miR-
Externí odkaz:
https://doaj.org/article/efc8cc1341c0441eb787164e723e85a3
Autor:
Ximiao Chen, Xuwei Zhu, Yu Chen, Zihang Ruan, Yekai Zhang, Hongqiang Wu, Xiaolei Zhang, Weiyang Gao
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116918- (2024)
Random-pattern skin flaps are important method for skin reconstruction after defect; however, the distal end of flaps is not easily viable due to inadequate nutrient supply. Erastin is a well-established ferroptosis inducer, but our study found that
Externí odkaz:
https://doaj.org/article/7b93a2b1b8334509bfe3d06cbbae547e
Publikováno v:
PeerJ, Vol 12, p e17551 (2024)
Background Keloid is a chronic proliferative fibrotic disease caused by abnormal fibroblasts proliferation and excessive extracellular matrix (ECM) production. Numerous fibrotic disorders are significantly influenced by ferroptosis, and targeting fer
Externí odkaz:
https://doaj.org/article/4344110657604e8cba797758c255c33b
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 39, Iss 12, Pp 1190-1199 (2023)
Abstract This study aimed to explore the role and mechanism of DYRK1a regulating ferroptosis of cardiomyocytes during myocardial ischemia–reperfusion injury (MIRI). H9c2 cells treated with oxygen–glucose deprivation/reoxygenation (OGD/R) were use
Externí odkaz:
https://doaj.org/article/fa8b18bede904723a1778599a25194bf
Autor:
Simona D’Aprile, Simona Denaro, Anna Maria Pavone, Sebastiano Giallongo, Cesarina Giallongo, Alfio Distefano, Lucia Salvatorelli, Filippo Torrisi, Raffaella Giuffrida, Stefano Forte, Daniele Tibullo, Giovanni Li Volti, Gaetano Magro, Nunzio Vicario, Rosalba Parenti
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Background Follicular thyroid cancer (FTC) is a prevalent form of differentiated thyroid cancer, whereas anaplastic thyroid cancer (ATC) represents a rare, fast-growing, undifferentiated, and highly aggressive tumor, posing significant chall
Externí odkaz:
https://doaj.org/article/2b0296fe90f944bbb837cf74617b2e11