Proteome and Phosphoproteome Profiling Reveal the Toxic Mechanism of Clostridium perfringens Epsilon Toxin in MDCK Cells.

Autor: Yue, Nan¹ (AUTHOR) yn18795116327@163.com, Huang, Jing² (AUTHOR) huangjing@nieh.chinacdc.cn, Dong, Mingxin³ (AUTHOR) realdmx311@163.com, Li, Jiaxin¹ (AUTHOR) ljx1658675586@163.com, Gao, Shan¹ (AUTHOR) gaoshan845@163.com, Wang, Jing¹ (AUTHOR) amms_wj@163.com, Wang, Yingshuang⁴ (AUTHOR) wangys19@mails.jlu.edu.cn, Li, Dongxue¹ (AUTHOR) dongxueli@163.com, Luo, Xi¹ (AUTHOR) luoxi18907093302@163.com, Liu, Tingting¹ (AUTHOR) liutingtingwushi@163.com, Han, Songyang¹ (AUTHOR) hansongyang0.0@outlook.com, Dong, Lina¹ (AUTHOR) donglina2024@163.com, Chen, Ming¹ (AUTHOR) chenming3901@163.com, Wang, Jinglin¹ (AUTHOR) wjlwjl0801@sina.com, Xu, Na⁵ (AUTHOR) xuna@jlmu.edu.cn, Kang, Lin¹ (AUTHOR) kanglin@bmi.ac.cn, Xin, Wenwen¹ (AUTHOR) xuna@jlmu.edu.cn

Publikováno v: Toxins. Sep2024, Vol. 16 Issue 9, p394. 19p.

The epsilon toxin from Clostridium perfringens stimulates calcium‐activated chloride channels, generating extracellular vesicles in Xenopus oocytes

Autor: Mercè Cases, Jonatan Dorca‐Arévalo, Marta Blanch, Sergi Rodil, Beatrice Terni, Mireia Martín‐Satué, Artur Llobet, Juan Blasi, Carles Solsona

Publikováno v: Pharmacology Research & Perspectives, Vol 12, Iss 5, Pp n/a-n/a (2024)

Abstract The epsilon toxin (Etx) from Clostridium perfringens has been identified as a potential trigger of multiple sclerosis, functioning as a pore‐forming toxin that selectively targets cells expressing the plasma membrane (PM) myelin and lympho

Externí odkaz: https://doaj.org/article/914e5c64d72f4982908239b999830e6a

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In silico vaccine design: Targeting highly epitopic regions of Clostridium perfringens type D epsilon toxin and Clostridium novyi type B alpha toxin for optimal immunogenicity

Autor: Nastaran Ashoori, Mohammad Mehdi Ranjbar, Romana Schirhagl

Publikováno v: Computational and Structural Biotechnology Journal, Vol 25, Iss , Pp 153-164 (2024)

Livestock infections caused by highly toxic bacteria, such as Clostridium perfringens type D and Clostridium novyi type B, present significant challenges in veterinary medicine. Such infections often require complex and elusive treatment regimens. De

Externí odkaz: https://doaj.org/article/d260b274aa72493d99f3128a6e4f4eea

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