Výsledky vyhledávání - "epithelial‐mesenchymal transition (EMT)"

Akademický článek

Transplantation of human umbilical cord blood mononuclear cells promotes functional endometrium reconstruction via downregulating EMT in damaged endometrium

Autor: Ruomeng Hu, Ying Wang, Wenwen Li, Hongjiang Liu, Rong Wu, Xuan Xu, Xiaohua Jiang, Qiong Xing, Jianye Wang, Zhaolian Wei

Publikováno v: Regenerative Therapy, Vol 27, Iss , Pp 279-289 (2024)

Introduction: Cell transplantation is an emerging and effective therapeutic approach for enhancing uterine adhesions caused by endometrial damage. Currently, human umbilical cord blood mononuclear cells (HUCBMCs) have been extensively for tissue and

Externí odkaz: https://doaj.org/article/0ebdf4d8c53a40089222942036367f05

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Smad4 regulates TGF-β1-mediated hedgehog activation to promote epithelial-to-mesenchymal transition in pancreatic cancer cells by suppressing Gli1 activity

Autor: Hangcheng Guo, Zujian Hu, Xuejia Yang, Ziwei Yuan, Mengsi Wang, Chaoyue Chen, Lili Xie, Yuanyuan Gao, Wangjian Li, Yongheng Bai, Chunjing Lin

Publikováno v: Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1189-1200 (2024)

Pancreatic cancer (PC) is an aggressive and metastatic gastrointestinal tumor with a poor prognosis. Persistent activation of the TGF-β/Smad signaling induces PC cell (PCC) invasion and infiltration via epithelial-to-mesenchymal transition (EMT). He

Externí odkaz: https://doaj.org/article/d9af0ac656924a8a9c44b7a043c4c60d

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Promotive effect of cancer-testis antigen CT57 on proliferation, invasion, migration and epithelial-mesenchymal transition of liver cancer cells

Autor: LUO Lange, ZHENG Chao, LEI Ming

Publikováno v: Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 44, Iss 11, Pp 1335-1346 (2024)

Objective·To investigate the effect of cancer-testis antigen family member CT57 on proliferation, migration and invasion of the human liver cancer cells and tumorigenesis in nude mice, and the possible mechanism.Methods·Bioinformatics methods were

Externí odkaz: https://doaj.org/article/3fc811ec1caa47a7a2b0399cf5ba79bd

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Akademický článek

Mesenchymal Stem Extracellular Vesicles in Various Respiratory Diseases: A New Opportunity

Autor: Hu Z, Zhu L, Zhu Y, Xu Y

Publikováno v: Journal of Inflammation Research, Vol Volume 17, Pp 9041-9058 (2024)

Zijun Hu,1,* Lujian Zhu,2,* Yanglin Zhu,3 Yejin Xu2 1School of Medicine, Shaoxing University, Shaoxing, Zhejiang, People’s Republic of China; 2Department of Infectious Disease, Affiliated Jinhua Hospital, Zhejiang University School of Medic

Externí odkaz: https://doaj.org/article/37614e261b89443fa3f4db1351b03f04

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Gut microbial and metabolomics profiles reveal the potential mechanism of fecal microbiota transplantation in modulating the progression of colitis-associated colorectal cancer in mice

Autor: Qishi Song, Yongchao Gao, Kun Liu, Yukai Tang, Yichun Man, Haijun Wu

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-21 (2024)

Abstract Purpose Intestinal flora promotes the pathogenesis of colorectal cancer (CRC) through microorganisms and their metabolites. This study aimed to investigate the composition of intestinal flora in different stages of CRC progression and the ef

Externí odkaz: https://doaj.org/article/9755ddf2e73b4bf4865ae5ac6d0d3118

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Akademický článek

Mechanistic study on the promotion of pancreatic cancer progression through upregulation of ZNF143 by dysregulated fatty acid metabolism

Autor: YU Siwei, XU Ziqi, TAO Mengyu, FAN Guangjian

Publikováno v: Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 44, Iss 10, Pp 1255-1265 (2024)

Objective·To identify key genes that may be regulated by fatty acid alteration in pancreatic cancer through tumor transcriptome screening, and to explore the expression of zinc finger protein 143 (ZNF143) in pancreatic cancer and its effect on the m

Externí odkaz: https://doaj.org/article/f1468826a6214b1a857df6b666113ccf

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Akademický článek

Vitronectin promotes proliferation and metastasis of cervical cancer cells via the epithelial-mesenchymal transition

Autor: Yao Lin, Lihong Bian, Guangwei Zhu, Bin Zhang

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

BackgroundVitronectin (VTN) is a multifunctional glycoprotein in blood and the extracellular, which could be an effective biomarker for many cancers. However, its role in cervical cancer is under investigated. In this study, we aimed to determine the

Externí odkaz: https://doaj.org/article/6ca5047a84294882b869975ce47eb91a

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N6-methyladenosine modification and post-translational modification of epithelial–mesenchymal transition in colorectal cancer

Autor: Yingnan Wang, Yufan Chen, Miaomiao Zhao

Publikováno v: Discover Oncology, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Colorectal cancer is a leading cause of cancer-related mortality worldwide. Traditionally, colorectal cancer has been recognized as a disease caused by genetic mutations. However, recent studies have revealed the significant role of epigenet

Externí odkaz: https://doaj.org/article/924ae2f767e34e4e981d3f4876ce1457

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Elevated SLC1A5 associated with poor prognosis and therapeutic resistance to transarterial chemoembolization in hepatocellular carcinoma

Autor: Guixiong Zhang, Yitai Xiao, Jizhou Tan, Hang Liu, Wenzhe Fan, Jiaping Li

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)

Abstract Background Hepatocellular carcinoma (HCC) is a common malignant tumor, and glutamine is vital for tumor cells. The role of glutamine transporter SLC1A5 in tumor progression and transarterial chemoembolization (TACE) efficacy is under study.

Externí odkaz: https://doaj.org/article/fda1a8b24d754d42a359bc5deab8d901

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