Zobrazeno 1 - 10
of 2 531
pro vyhledávání: '"epigenetic therapy"'
Autor:
Rajkumar Prabhakaran, Rajkumar Thamarai, Sivabalan Sivasamy, Sivanesan Dhandayuthapani, Jyoti Batra, Chinnaperumal Kamaraj, Krishnasamy Karthik, Mohd Asif Shah, Saurav Mallik
Publikováno v:
Epigenetics & Chromatin, Vol 17, Iss 1, Pp 1-26 (2024)
Abstract Cancer has arisen from both genetic mutations and epigenetic changes, making epigenetics a crucial area of research for innovative cancer prevention and treatment strategies. This dual perspective has propelled epigenetics into the forefront
Externí odkaz:
https://doaj.org/article/d7e8adf536474b2d912bd92ba56da165
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 10623-10637 (2024)
Tingyi Li,1,2 Yanwei Chen,1 Shuai Li1 1Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian, People’s Republic of China; 2Dalian Medical University, Dalian, People’s Republic of ChinaCorrespondence: Shuai Li;
Externí odkaz:
https://doaj.org/article/77c031e33dad4522b11d075a748d9a68
Autor:
Odimegwu CL, Uwaezuoke SN, Chikani UN, Mbanefo NR, Adiele KD, Nwolisa CE, Eneh CI, Ndiokwelu CO, Okpala SC, Ogbuka FN, Odo KE, Ohuche IO, Obiora-Izuka CE
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity, Vol Volume 17, Pp 3557-3576 (2024)
Chioma Laura Odimegwu,1 Samuel Nkachukwu Uwaezuoke,1 Ugo N Chikani,1 Ngozi Rita Mbanefo,1 Ken Daberechi Adiele,1 Charles Emeka Nwolisa,2 Chizoma Ihuarula Eneh,3 Chibuzo Obiora Ndiokwelu,1 Somkenechi C Okpala,1 Francis N Ogbuka,3 Kenneth E Odo,1 Ijeom
Externí odkaz:
https://doaj.org/article/62c65267d0ff4ea38cb6f0114a98fc73
Autor:
Zhongyao Chen, Qiang Gao, Yukui Shang, Behzad Nasiri Ahmadabadi, Yawei Hu, Wei Zhang, Peng Liu
Publikováno v:
hLife, Vol 2, Iss 9, Pp 471-487 (2024)
Diffuse midline glioma (DMG), H3K27-altered, is lethal pediatric-type, high-grade, localized to the midline region of the central nervous system. Effective treatment guidelines are absent, and clinical trials are preferred for primary or recurrent DM
Externí odkaz:
https://doaj.org/article/ec2b8c3e14d849329f83bfc493b44ce0
Autor:
Fernanda Aparecida dos Santos France, Debora Kazumi Maeda, Ana Beatriz Rodrigues, Mai Ono, Franciele Lopes Nogueira Marchetti, Marcos Martins Marchetti, Allana Cristina Faustino Martins, Roberto da Silva Gomes, Cláudia Aparecida Rainho
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
A differential diet with royal jelly (RJ) during early larval development in honeybees shapes the phenotype, which is probably mediated by epigenetic regulation of gene expression. Evidence indicates that small molecules in RJ can modulate gene expre
Externí odkaz:
https://doaj.org/article/968142f9a79c4caeba42f6be39b72e3b
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-26 (2024)
Abstract The onerous health and economic burden associated with head and neck squamous cell carcinoma (HNSCC) is a global predicament. Despite the advent of novel surgical techniques and therapeutic protocols, there is an incessant need for efficacio
Externí odkaz:
https://doaj.org/article/65ae246e12bd41708ef694f5c0d3a147
Autor:
Hong Ren, Zhenkai Wu, Jia Tan, Hui Tao, Wangyuan Zou, Zheng Cao, Binyu Wen, Ziyi Cai, Jiaqi Du, Zhihong Deng
Publikováno v:
Advanced Science, Vol 11, Iss 31, Pp n/a-n/a (2024)
Abstract In the treatment of uveal melanoma (UVM), histone deacetylase inhibitors (HDACi) have emerged as a promising epigenetic therapy. However, their clinical efficacy is hindered by the suboptimal pharmacokinetics and the strong self‐rescue of
Externí odkaz:
https://doaj.org/article/4462f23225bb4214813ff785ad2925ff
Autor:
Hanghang Zhang, Chen Huang, John Gordon, Sijia Yu, George Morton, Wayne Childers, Magid Abou-Gharbia, Yi Zhang, Jaroslav Jelinek, Jean-Pierre J. Issa
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Inhibition of cyclin-dependent kinase 9 (CDK9), a novel epigenetic target in cancer, can reactivate epigenetically silenced genes in cancer by dephosphorylating the SWI/SNF chromatin remodeler BRG1. Here, we characterized the anti
Externí odkaz:
https://doaj.org/article/892c78200eb14c6280a512cb5e5194fd
Publikováno v:
Military Medical Research, Vol 10, Iss 1, Pp 1-24 (2023)
Abstract Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) has revolutionized the field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of CD8+ tumor-infiltrating lymphocytes (TILs), which is termed T
Externí odkaz:
https://doaj.org/article/e63043ae2e154af6a2841677d1fd83cc
Autor:
Eleanor O’Brien, Carmen Tse, Ian Tracy, Ian Reddin, Joanna Selfe, Jane Gibson, William Tapper, Reuben J. Pengelly, Jinhui Gao, Ewa Aladowicz, Gemma Petts, Khin Thway, Sergey Popov, Anna Kelsey, Timothy J. Underwood, Janet Shipley, Zoë S. Walters
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background Rhabdomyosarcomas (RMS) are predominantly paediatric sarcomas thought to originate from muscle precursor cells due to impaired myogenic differentiation. Despite intensive treatment, 5-year survival for patients with advanced disea
Externí odkaz:
https://doaj.org/article/b09403c2536c486da89cc39dfaf84132