Zobrazeno 1 - 10
of 186
pro vyhledávání: '"epigenetic drug"'
Autor:
Zhaofeng Li, Peixin Liu, Wei Chen, Xueying Liu, Fan Tong, Junhui Sun, Yang Zhou, Ting Lei, Wenqin Yang, Dong Ma, Huile Gao, Yi Qin
Publikováno v:
Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Breast cancer bone metastasis has become a common cancer type that still lacks an effective treatment method. Although epigenetic drugs have demonstrated promise in cancer therapy, their nontargeted accumulation and drug resistance remain no
Externí odkaz:
https://doaj.org/article/9b3f77cd9a714fe29b7a6cc41f13b4a1
Autor:
Haruka Shinohara, Rie Sawado, Makoto Nakagawa, Ayuna Hattori, Kazutsune Yamagata, Kimiharu Tauchi, Jumpei Ito, Yasumichi Kuwahara, Tsukasa Okuda, Chitose Ogawa, Issay Kitabayashi
Publikováno v:
Molecular Therapy: Oncolytics, Vol 27, Iss , Pp 14-25 (2022)
Malignant rhabdoid tumors (MRTs) are rare and highly aggressive pediatric cancers with no standard of care. MRTs are characterized by loss of SMARCB1, which results in upregulated expression of enhancer of zeste homolog 2 (EZH2), which is responsible
Externí odkaz:
https://doaj.org/article/20b4e9bb9f2b401e9e56e32a3e37b927
Autor:
Akihito Koseki, Natsumi Araya, Makoto Yamagishi, Junji Yamauchi, Naoko Yagishita, Naoki Takao, Katsunori Takahashi, Yasuo Kunitomo, Daisuke Honma, Kazushi Araki, Kaoru Uchimaru, Tomoo Sato, Yoshihisa Yamano
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
BackgroundHuman T-cell leukemia virus type 1 (HTLV-1) causes HTLV-1-associated myelopathy (HAM), adult T-cell leukemia/lymphoma (ATL), HTLV-1-associated uveitis, and pulmonary diseases. Although both HAM and ATL show proliferation of infected cells,
Externí odkaz:
https://doaj.org/article/47d93328090c4848b899ff080194dfab
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Epigenetic regulation plays an important role in the occurrence, development and treatment of tumors. The histone methyltransferase SET-domain-containing 2 (SETD2) plays a key role in mammalian epigenetic regulation by catalyzing histone methylation
Externí odkaz:
https://doaj.org/article/5862e7e4fb2d41159634c36881c8c1fa
Autor:
Karen Xu, Karthik Ramesh, Vicki Huang, Saumya S. Gurbani, James Scott Cordova, Eduard Schreibmann, Brent D. Weinberg, Soma Sengupta, Alfredo D. Voloschin, Matthias Holdhoff, Peter B. Barker, Lawrence R. Kleinberg, Jeffrey J. Olson, Hui-Kuo G. Shu, Hyunsuk Shim
Publikováno v:
Tomography, Vol 8, Iss 2, Pp 688-700 (2022)
Glioblastoma (GBM) is highly aggressive and has a poor prognosis. Belinostat is a histone deacetylase inhibitor with blood–brain barrier permeability, anti-GBM activity, and the potential to enhance chemoradiation. The purpose of this clinical tria
Externí odkaz:
https://doaj.org/article/c5d64c1e66924dba9ace3ae3ee5433e3
Autor:
Liwen Ren, Yihui Yang, Wan Li, Hong Yang, Yizhi Zhang, Binbin Ge, Sen Zhang, Guanhua Du, Jinhua Wang
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
Tumor development is frequently accompanied by abnormal expression of multiple genomic genes, which can be broadly viewed as decreased expression of tumor suppressor genes and upregulated expression of oncogenes. In this process, epigenetic regulatio
Externí odkaz:
https://doaj.org/article/62baab2163a641d190101bd7cc5eebb7
Autor:
Xiao Hu, Yanli Zou, David A. Copland, Lauren P. Schewitz-Bowers, Yan Li, Philippa J.P. Lait, Madeleine Stimpson, Zhihui Zhang, Shixin Guo, Juanran Liang, Tingting Chen, Jing Jing Li, Sujing Yuan, Shuo Li, Penghui Zhou, Yizhi Liu, Andrew D. Dick, Xiaofeng Wen, Richard W.J. Lee, Lai Wei
Publikováno v:
EBioMedicine, Vol 86, Iss , Pp 104333- (2022)
Summary: Background: Targeting helper T cells, especially Th17 cells, has become a plausible therapy for many autoimmune diseases. Methods: Using an in vitro culture system, we screened an epigenetics compound library for inhibitors of IFN-γ and IL-
Externí odkaz:
https://doaj.org/article/dce4fca18ab64f41960149c18270ac90
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/328747785d754fe690b33627b8f2416f
Autor:
Bing-Heng Yang, Wei-Zhi Lin, Yu-Ting Chiang, Yeu-Chin Chen, Chi-Hsiang Chung, Wu-Chien Chien, Chia-Yang Shiau
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundAlthough several epigenetic drugs have been reported to have therapeutic efficacy for some hematologic neoplasms (HNs) in clinical trials, few achieved disease-free survival benefit. The traditional drug discovery pathway is costly and time
Externí odkaz:
https://doaj.org/article/30e68559e97b4d1ba656bf66ee56e62a