Zobrazeno 1 - 10
of 966
pro vyhledávání: '"epigenetic alterations"'
Autor:
Di Chen, Xinyu Gu, Yeltai Nurzat, Lixia Xu, Xueyuan Li, Lixin Wu, Henan Jiao, Peng Gao, Xuqiang Zhu, Dongming Yan, Shaohua Li, Chen Xue
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-33 (2024)
Abstract Drug resistance in cancer cells significantly diminishes treatment efficacy, leading to recurrence and metastasis. A critical factor contributing to this resistance is the epigenetic alteration of gene expression via RNA modifications, such
Externí odkaz:
https://doaj.org/article/8d111056073847008c22595c2d0878ea
Publikováno v:
International Journal of Yoga, Vol 17, Iss 1, Pp 10-19 (2024)
Infertility, a widespread medical condition affecting numerous couples globally, persists as a challenge despite advances in assisted reproductive technologies (ARTs), often burdened by financial, physical, and emotional strains. Complementary and al
Externí odkaz:
https://doaj.org/article/8ff60e28512541c99478efcc2ad4d413
Autor:
Manu Yadav, Ishita Vaishkiar, Ananya Sharma, Akanksha Shukla, Aradhana Mohan, Madhuri Girdhar, Anil Kumar, Tabarak Malik, Anand Mohan
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
Traditional medication and alternative therapies have long been used to treat breast cancer. One of the main problems with current treatments is that there is an increase in drug resistance in the cancer cells owing to genetic differences such as mut
Externí odkaz:
https://doaj.org/article/830e7e98583342e2a7267b376765e08f
Autor:
Giulia Ambrosini, Marco Cordani, Ali Zarrabi, Sergio Alcon-Rodriguez, Rosa M. Sainz, Guillermo Velasco, Pedro Gonzalez-Menendez, Ilaria Dando
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Prostate cancer, as one of the most prevalent malignancies in males, exhibits an approximate 5-year survival rate of 95% in advanced stages. A myriad of molecular events and mutations, including the accumulation of oncometabolites, underpin
Externí odkaz:
https://doaj.org/article/f7de861908ba488998eaa45fa750eeaf
Publikováno v:
Brain Sciences, Vol 14, Iss 8, p 769 (2024)
Substance use disorders (SUDs) are complex biopsychosocial diseases that cause neurocognitive deficits and neurological impairments by altering the gene expression in reward-related brain areas. Repeated drug use gives rise to alterations in DNA meth
Externí odkaz:
https://doaj.org/article/ab082f3cad3441159fa68c382ec441bf
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Breast cancer (BC) is the most common non-skin cancer and the second leading cause of cancer death in American women. The initiation and progression of BC can proceed through the accumulation of genetic and epigenetic changes that allow transformed c
Externí odkaz:
https://doaj.org/article/31f6bc26e86e470c8dbedc693122577e
Autor:
Dimitrina Miteva, Tsvetelina Velikova
Publikováno v:
Anti-Aging Eastern Europe, Vol 2, Iss 1, Pp 29-35 (2023)
Immunosenescence or aging of the immune system is characterized by dysregulation of the innate and adaptive immune system mechanisms, associated with a systemic low-grade inflammation (i.e., «inflammaging»), non-effective protective humoral and cel
Externí odkaz:
https://doaj.org/article/0caac54592174d3aa00ef9eb6695ee36
Autor:
Francesca Marini, Francesca Giusti, Gaia Palmini, Cinzia Aurilia, Simone Donati, Maria Luisa Brandi
Publikováno v:
Endocrines, Vol 4, Iss 1, Pp 205-235 (2023)
Parathyroid carcinoma (PC) is a very rare endocrine cancer with aggressive behavior, a high metastatic potential, and a poor prognosis. Surgical resection of affected gland(s) and other involved structures is the elective therapy. Pre-operative and i
Externí odkaz:
https://doaj.org/article/a5f57f072a1e412ca4c6488930a3af7d
Autor:
Priyanka Sahu, Chantal Donovan, Keshav Raj Paudel, Sophie Pickles, Vrushali Chimankar, Richard Y. Kim, Jay C. Horvart, Kamal Dua, Antonio Ieni, Francesco Nucera, Helle Bielefeldt-Ohmann, Sarah Mazilli, Gaetano Caramori, J. Guy Lyons, Philip M. Hansbro
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Primary lung carcinoma or lung cancer (LC) is classified into small-cell or non-small-cell (NSCLC) lung carcinoma. Lung squamous cell carcinoma (LSCC) is the second most common subtype of NSCLC responsible for 30% of all LCs, and its survival remains
Externí odkaz:
https://doaj.org/article/b3a0684f86d348c3918d4772d5cf4d2b
Autor:
Amanda M. Simanek, Regina Manansala, Jennifer M.P. Woo, Helen C. S. Meier, Belinda L. Needham, Paul L. Auer
Publikováno v:
Epigenetics, Vol 17, Iss 13, Pp 1976-1990 (2022)
Prenatal socioeconomic disadvantage (SD) has been linked to DNA methylation (DNAm) in adulthood, but whether such epigenetic alterations are present at birth remains unclear. We carried out an epigenome-wide analysis of the association between severa
Externí odkaz:
https://doaj.org/article/54e90af3af614e08b0aeda5db2250af1